Recombinant Human CEACAM-7 Protein, CF Summary
Product Specifications
CEACAM-1/CD66a (Catalog # 2244-CM) that produces 50% of the optimal binding response is approximately 1.6-8 ng/mL.
Thr36-Asn233, with a C-terminal 6-His tag
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
9010-CM
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS |
| Reconstitution | Reconstitute at 500 μg/mL in PBS. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: |
Reconstitution Calculator
Background: CEACAM-7
Carcinoembryonic antigen-related cell adhesion molecule 7 (CEACAM-7), also known as CGM2, is an approximately 40 kDa GPI-anchored glycoprotein in the CEACAM family of adhesion molecules (1). Mature human CEACAM-7 consists of two Ig-like domains followed by the GPI anchor (2). Alternative splicing generates a short isoform that lacks the second Ig-like domain. CEACAM-7 is preferentially expressed on the luminal surface of epithelial cells near the mouth of colonic crypts and on pancreatic ductal epithelial cells (3, 4). It is down-regulated during colorectal adenoma progression (2-6) but can be up-regulated during the development of gastric carcinoma (7). R&D Systems in-house testing indicates that CEACAM-7 binds to CEACAM-1, consistent with the heterophilic interaction of CEACAM-1 with other CEACAM family members (1, 8, 9).
- Tchoupa, A.K. et al. (2014) Cell Commun. Signal. 12:27.
- Thompson, J. et al. (1994) J. Biol. Chem. 269:32924.
- Thompson, J. et al. (1997) Cancer Res. 57:1776.
- Scholzel, S. et al. (2000) Am. J. Pathol. 156:595.
- Nollau, P. et al. (1997) Cancer Res. 57:2354.
- Nollau, P. et al. (1997) Am. J. Pathol. 151:521.
- Zhou, J. et al. (2011) World J. Surgical Oncol. 9:172.
- Markel, G. et al. (2004) J. Immunol. 173:3732.
- Oikawa, S. et al. (1992) Biochem. Biophys. Res. Commun. 186:881.
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