Recombinant Human HIN-1/SCGB3A1 Protein, CF Summary
Product Specifications
Phe21-Gly104
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
2790-HN
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
| Reconstitution | Reconstitute at 250 μg/mL in PBS. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Reconstitution Calculator
Background: HIN-1/SCGB3A1
High in Normal‑1 (HIN‑1), also known as Uteroglobin related protein 2 (UGRP2), is an 8 kDa secreted protein of the secretoglobin superfamily (SCGB3A1) (1). HIN‑1 is expressed in bronchial epithelial and secretory Clara cells, mammary epithelial cells (particularly during pregnancy), salivary glands, and the prostate (2‑5). It is up‑regulated in Clara cells by IL‑4, IL‑13, Oncostatin M, EGF, and TGF‑ alpha and down‑regulated by IFN‑ alpha, beta, and gamma (6‑9). It is secreted into bronchial lavage fluid, saliva, and plasma, and may form disulfide‑linked dimers (10). HIN‑1 binds to the macrophage scavenger receptor MARCO, and to the surface of mammary and bronchial epithelial cells (11, 12). HIN‑1 promotes apoptosis and inhibits the proliferation, migration, and invasion of breast cancer cells (12). The down‑regulation of HIN‑1 expression in many breast, lung, and prostate cancers correlates with hypermethylation of its promoter (4, 10, 13, 14). Mature human HIN‑1 shares 58% and 62% aa sequence identity with mouse and rat HIN‑1, respectively (4).
- Mukherjee, A.B. et al. (2007) Endocr. Rev. 28:707.
- Porter, D. et al. (2002) Mech. Dev. 114:201.
- Reynolds, S.D. et al. (2002) Am. J. Respir. Crit. Care Med. 166:1498.
- Krop, I. et al. (2001) Proc. Natl. Acad. Sci. 98:9796.
- Niimi, T. et al. (2002) Cytogenet. Genome Res. 97:120.
- Yamada, A. et al. (2005) J. Immunol. 175:5708.
- Tomita, T. et al. (2009) Am. J. Respir. Cell Mol. Biol. 40:620.
- Yamada, A. and S. Kimura (2005) FEBS Lett. 579:2221.
- Yamada, A. et al. (2009) Biochem. Biophys. Res. Commun. 379:964.
- Krop, I. et al. (2004) Mol. Cancer Res. 2:489.
- Bin, L.-H. et al. (2003) J. Immunol. 171:924.
- Krop, I. et al. (2005) Cancer Res. 65:9659.
- Krop, I. et al. (2003) Cancer Res. 63:2024.
- Shigematsu, H. et al. (2005) Int. J. Cancer 113:600.
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