Home / IL-12 / Recombinant Human IL-12 Protein

Recombinant Human IL-12 Protein

Catalog #: 219-IL
139 Citations 2 Reviews Datasheet / COA / SDS

Bigger Scale, More Savings. Try our NEW version of Human Recombinant IL-12 (10018-IL). Combining R&D Systems quality with scalability that allows for lower price points and a solid supply chain.

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Carrier Free

Catalog # Availability Size / Price Qty
219-IL-005/CF
219-IL-025/CF

With Carrier

Catalog # Availability Size / Price Qty
219-IL-005
219-IL-025
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Product Details
Citations (139)
FAQs
Reviews (2)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human IL-12 Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using PHA-stimulated human T lymphoblasts. Symons, J.A. et al. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 272. The ED50 for this effect is 0.01-0.05 ng/mL.
Source
Spodoptera frugiperda, Sf 21 (baculovirus)-derived human IL-12 protein
Human IL-12 p40
(Ile23-Ser328)
Accession # P29460
Human IL-12 p35
(Arg23-Ser219)
Accession # P29459
N-terminus C-terminus
Accession #
P29460 (p40) & P29459 (p35)
N-terminal Sequence
Analysis
Ile23 (p40) & Arg23 (p35)
Structure / Form
Disulfide-linked heterodimer
Predicted Molecular Mass
34.7 kDa (p40) & 22.5 kDa (p35)
SDS-PAGE
41 kDa (p40) & 29 kDa (p35), reducing conditions

Product Datasheets

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219-IL (with carrier)

Product Datasheet
COA
SDS

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219-IL/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

219-IL

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 50 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

219-IL/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute 5 µg vials at 50 µg/mL in sterile PBS. Reconstitute 25 µg or larger vials at 100 µg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IL-12

Interleukin 12, also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a pleiotropic cytokine originally identified in the medium of activated human B lymphoblastoid cell lines. The p40 subunit of IL-12 has been shown to have extensive amino acid sequence homology to the extracellular domain of the human IL-6 receptor while the p35 subunit shows distant but significant sequence similarity to IL-6, G-CSF, and chicken MGF. These observations have led to the suggestion that IL-12 might have evolved from a cytokine/soluble receptor complex. Human and murine IL-12 share 70% and 60% amino acid sequence homology in their p40 and p35 subunits, respectively. IL-12 apparently shows species specificity with human IL-12 reportedly showing minimal activity in the murine system.

IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and natural killer (NK) cells. These effects include inducing production of IFN-gamma and TNF by resting and activated T and NK cells, synergizing with other IFN-gamma  inducers at both the transcriptional and post-transcriptional levels. This interaction induces IFN-gamma  gene expression, enhancing the cytotoxic activity of resting NK and T cells, inducing and synergizing with IL-2 in the generation of lymphokine-activated killer (LAK) cells, acting as a co-mitogen to stimulate proliferation of resting T cells, and inducing proliferation of activated T and NK cells. Current evidence indicates that IL‑12, produced by macrophages in response to infectious agents, is a central mediator of the cell‑mediated immune response by its actions on the development, proliferation, and activities of TH1 cells. In its role as the initiator of cell-mediated immunity, it has been suggested that IL-12 has therapeutic potential as a stimulator of cell-mediated immune responses to microbial pathogens, metastatic cancers, and viral infections such as AIDS.

Long Name
Interleukin 12
Entrez Gene IDs
3592 (Human); 16159 (Mouse); 84405 (Rat); 397053 (Porcine); 403977 (Canine); 102115316 (Cynomolgus Monkey); 493741 (Feline); 703205 (Rhesus Macaque)
Alternate Names
CLMF p35; CLMF1; Cytotoxic lymphocyte maturation factor 35 kDa subunit; IL-12 subunit p35; IL12; IL-12; IL-12, subunit p35; IL12A; interleukin 12, p35; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocytematuration factor 1, p35); interleukin-12 alpha chain; interleukin-12 subunit alpha; natural killer cell stimulatory factor 1, 35 kD subunit; NF cell stimulatory factor chain 1; NK cell stimulatory factor chain 1; NKSF1; p35

Citations for Recombinant Human IL-12 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

139 Citations: Showing 1 - 10
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  1. Tuberculosis in otherwise healthy adults with inherited TNF deficiency
    Authors: Arias, AA;Neehus, AL;Ogishi, M;Meynier, V;Krebs, A;Lazarov, T;Lee, AM;Arango-Franco, CA;Yang, R;Orrego, J;Corcini Berndt, M;Rojas, J;Li, H;Rinchai, D;Erazo-Borrás, L;Han, JE;Pillay, B;Ponsin, K;Chaldebas, M;Philippot, Q;Bohlen, J;Rosain, J;Le Voyer, T;Janotte, T;Amarajeeva, K;Soudée, C;Brollo, M;Wiegmann, K;Marquant, Q;Seeleuthner, Y;Lee, D;Lainé, C;Kloos, D;Bailey, R;Bastard, P;Keating, N;Rapaport, F;Khan, T;Moncada-Vélez, M;Carmona, MC;Obando, C;Alvarez, J;Cataño, JC;Martínez-Rosado, LL;Sanchez, JP;Tejada-Giraldo, M;L'Honneur, AS;Agudelo, ML;Perez-Zapata, LJ;Arboleda, DM;Alzate, JF;Cabarcas, F;Zuluaga, A;Pelham, SJ;Ensser, A;Schmidt, M;Velásquez-Lopera, MM;Jouanguy, E;Puel, A;Krönke, M;Ghirardello, S;Borghesi, A;Pahari, S;Boisson, B;Pittaluga, S;Ma, CS;Emile, JF;Notarangelo, LD;Tangye, SG;Marr, N;Lachmann, N;Salvator, H;Schlesinger, LS;Zhang, P;Glickman, MS;Nathan, CF;Geissmann, F;Abel, L;Franco, JL;Bustamante, J;Casanova, JL;Boisson-Dupuis, S;
    Nature
    Species: Human
    Sample Types: Plasma, Whole Cells
    Applications: Bioassay
  2. Cytokine Response of Natural Killer Cells to Hepatitis B Virus Infection Depends on Monocyte Co-Stimulation
    Authors: Kupke, P;Brucker, J;Wettengel, JM;Protzer, U;Wenzel, JJ;Schlitt, HJ;Geissler, EK;Werner, JM;
    Viruses
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. SIRT3 negatively regulates TFH cell differentiation in cancer
    Authors: Hou, Y;Cao, Y;He, Y;Dong, L;Zhao, L;Dong, Y;Niu, R;Bi, Y;Liu, G;
    Cancer immunology research
    Species: Mouse, Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. IL7 increases targeted lipid nanoparticle-mediated mRNA expression in T cells in vitro and in vivo by enhancing T cell protein translation
    Authors: Tilsed, CM;Sadiq, BA;Papp, TE;Areesawangkit, P;Kimura, K;Noguera-Ortega, E;Scholler, J;Cerda, N;Aghajanian, H;Bot, A;Mui, B;Tam, Y;Weissman, D;June, CH;Albelda, SM;Parhiz, H;
    Proceedings of the National Academy of Sciences of the United States of America
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. The hTERT and iCasp9 Transgenes Affect EOMES and T-BET Levels in NK Cells and the Introduction of Both Genes Improves NK Cell Proliferation in Response to IL2 and IL15 Stimulation
    Authors: Palamarchuk, AI;Kovalenko, EI;Streltsova, MA;
    Biomedicines
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. IL-15-secreting CAR natural killer cells directed toward the pan-cancer target CD70 eliminate both cancer cells and cancer-associated fibroblasts
    Authors: Van den Eynde, A;Gehrcken, L;Verhezen, T;Lau, HW;Hermans, C;Lambrechts, H;Flieswasser, T;Quatannens, D;Roex, G;Zwaenepoel, K;Marcq, E;Joye, P;Cardenas De La Hoz, E;Deben, C;Gasparini, A;Montay-Gruel, P;Le Compte, M;Lion, E;Lardon, F;Van Laere, S;Siozopoulou, V;Campillo-Davo, D;De Waele, J;Pauwels, P;Jacobs, J;Smits, E;Van Audenaerde, JRM;
    Journal of hematology & oncology
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Impact of IL-21 on Natural Killer cell proliferation and function - a mathematical and functional assessment
    Authors: Biondo, R;Nayak, I;Möker, N;Zhang, C;Stewart, WC;Khakoo, S;Das, J;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Generation and optimization of off-the-shelf immunotherapeutics targeting TCR-V?2+ T cell malignancy
    Authors: Ren, J;Liao, X;Lewis, JM;Chang, J;Qu, R;Carlson, KR;Foss, F;Girardi, M;
    Nature communications
    Species: Human
    Sample Types: Transduced Whole Cells
    Applications: Bioassay
  9. TNF? induced by DNA-sensing in macrophage compromises retinal pigment epithelial (RPE) barrier function
    Authors: Twarog, M;Schustak, J;Xu, Y;Coble, M;Dolan, K;Esterberg, R;Huang, Q;Saint-Geniez, M;Bao, Y;
    Scientific reports
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. An alphavbeta3 integrin checkpoint is critical for efficient TH2 cell cytokine polarization and potentiation of antigen-specific immunity
    Authors: ACH Szeto, ACF Ferreira, J Mannion, PA Clark, M Sivasubram, MWD Heycock, A Crisp, HE Jolin, P Kozik, MD Knolle, ANJ McKenzie
    Nature Immunology, 2022-12-22;24(1):123-135.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity
    Authors: E Cruz-Loren, NP Ramirez, J Lee, S Pandhe, L Wang, J Hernandez-, AM Spivak, V Planelles, T Petersen, MK Jain, ED Martinez, I D'Orso
    Viruses, 2022-10-18;14(10):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells
    Authors: YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra
    Science Advances, 2022-08-24;8(34):eabn5522.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor
    Authors: AKO Rode, TB Buus, V Mraz, FAH Al-Jaberi, DV Lopez, SL Ford, S Hennen, IP Eliasen, IV Klewe, L Gharehdagh, A Dragan, MM Rosenkilde, A Woetmann, L Skov, N Ødum, CM Bonefeld, M Kongsbak-W, C Geisler
    Cells, 2022-08-19;11(16):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Stimulation
  14. The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma Cells
    Authors: P Sekhri, DK Ledezma, A Shukla, EE Sweeney, R Fernandes
    Cancers, 2022-03-11;14(6):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  15. IL-27 Mediates PD-L1 Expression and Release by Human Mesothelioma Cells
    Authors: G Carbotti, B Dozin, S Martini, C Giordano, F Scordamagl, M Croce, G Filaci, S Ferrini, M Fabbi
    Cancers, 2021-08-09;13(16):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Biomarkers for Comorbidities Modulate the Activity of T-Cells in COPD
    Authors: K Jamal Jame, WJ Gallert, SD Yanik, S Panek, J Kronsbein, D Jungck, A Koch, J Knobloch
    International Journal of Molecular Sciences, 2021-07-02;22(13):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child
    Authors: M Ogishi, R Yang, C Aytekin, D Langlais, M Bourgey, T Khan, FA Ali, M Rahman, OM Delmonte, M Chrabieh, P Zhang, C Gruber, SJ Pelham, AN Spaan, J Rosain, WT Lei, S Drutman, MD Hellmann, MK Callahan, M Adamow, P Wong, JD Wolchok, G Rao, CS Ma, Y Nakajima, T Yaguchi, K Chamoto, SC Williams, JF Emile, F Rozenberg, MS Glickman, F Rapaport, G Kerner, G Allington, I Tezcan, D Cagdas, FO Hosnut, F Dogu, A Ikinciogul, VK Rao, L Kainulaine, V Béziat, J Bustamante, S Vilarinho, RP Lifton, B Boisson, L Abel, D Bogunovic, N Marr, LD Notarangel, SG Tangye, T Honjo, P Gros, S Boisson-Du, JL Casanova
    Nature Medicine, 2021-06-28;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. CAR directs T cell adaptation to bile acids in the small intestine
    Authors: ML Chen, X Huang, H Wang, C Hegner, Y Liu, J Shang, A Eliason, H Diao, H Park, B Frey, G Wang, SA Mosure, LA Solt, DJ Kojetin, A Rodriguez-, DA Schady, CT Weaver, ME Pipkin, DD Moore, MS Sundrud
    Nature, 2021-04-07;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Myeloid-derived suppressor cells and their association with vaccine immunogenicity in South African infants
    Authors: E Kidzeru, MA Gasper, D Shao, PT Edlefsen, N Lejarcegui, E Havyariman, K Urdahl, S Gantt, H Horton, H Jaspan, A Gervassi
    Journal of leukocyte biology, 2021-01-21;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Protective Immune Responses Elicited by Deglycosylated Live-Attenuated Simian Immunodeficiency Virus Vaccine Are Associated with IL-15 Effector Functions
    Authors: S Watanabe, M Fujino, Y Saito, N Ahmed, H Sato, C Sugimoto, T Okamura, K Hanaki, EE Nakayama, T Shioda, K Matsushima, AA Ansari, F Villinger, K Mori
    J. Immunol., 2020-08-03;0(0):.
    Species: Rhesus Macaque
    Sample Types: Whole Cells
    Applications: Bioassay
  21. T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation
    Authors: J Yan, SP Pandey, BJ Barnes, JR Turner, C Abraham
    Cell Rep, 2020-06-30;31(13):107820.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In�Vivo Persistence and Enhances Anti-tumor Activity
    Authors: H Zhu, RH Blum, D Bernareggi, EH Ask, Z Wu, HJ Hoel, Z Meng, C Wu, KL Guan, KJ Malmberg, DS Kaufman
    Cell Stem Cell, 2020-06-11;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Diminished toll-like receptor response in febrile infection-related epilepsy syndrome (FIRES)
    Authors: MY Hsieh, JJ Lin, SH Hsia, JL Huang, KW Yeh, KW Chang, WI Lee
    Biomed J, 2020-05-29;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Targeting of CD38 by the tumor suppressor miR-26a serves as a novel potential therapeutic agent in multiple myeloma
    Authors: Y Hu, H Liu, C Fang, C Li, F Xhyliu, H Dysert, J Bodo, G Habermehl, BE Russell, W Li, M Chappell, X Jiang, SL Ondrejka, ED Hsi, JP Maciejewsk, Q Yi, KC Anderson, NC Munshi, G Ao, JN Valent, J Lin, J Zhao
    Cancer Res., 2020-03-19;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  25. Recapitulating T cell infiltration in 3D psoriatic skin models for patient-specific drug testing
    Authors: JU Shin, HE Abaci, L Herron, Z Guo, B Sallee, A Pappalardo, J Jackow, EHC Wang, Y Doucet, AM Christiano
    Sci Rep, 2020-03-05;10(1):4123.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  26. Patients with Idiopathic Pulmonary Nontuberculous Mycobacterial Disease Have Normal Th1/Th2 Cytokine Responses but Diminished Th17 Cytokine and Enhanced Granulocyte-Macrophage Colony-Stimulating Factor Production
    Authors: UI Wu, KN Olivier, DB Kuhns, DL Fink, EP Sampaio, AM Zelazny, SJ Shallom, BE Marciano, MS Lionakis, SM Holland
    Open Forum Infect Dis, 2019-11-28;6(12):ofz484.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Invariant natural killer T cells are functionally impaired in patients with systemic sclerosis
    Authors: AC Pecher, F Kettemann, E Asteriti, H Schmid, S Duerr-Stoe, H Keppeler, JC Henes, R Klein, C Hinterleit, KA Secker, C Schneidawi, L Kanz, D Schneidawi
    Arthritis Res. Ther., 2019-10-15;21(1):212.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. IL-12Rbeta1 deficiency corresponding to concurrency of two diseases, mendelian susceptibility to mycobacterial disease and Crohn's disease
    Authors: R Khoshnevis, N Nekooei-Ma, C Klein, D Kotlarz, M Behnam, V Ostadi, M Yaran, A Rezaei, R Sherkat
    J Clin Tuberc Other Mycobact Dis, 2019-09-20;17(0):100123.
    Species: Human
    Sample Types: Whole Blood
    Applications: Bioassay
  29. Dissection of the Effects of JAK and BTK Inhibitors on the Functionality of Healthy and Malignant Lymphocytes
    Authors: T Hofland, I de Weerdt, H Ter Burg, R de Boer, S Tannheimer, SH Tonino, AP Kater, E Eldering
    J. Immunol., 2019-09-11;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity
    Authors: H Wang, L Shen, X Sun, F Liu, W Feng, C Jiang, X Chu, X Ye, C Jiang, Y Wang, P Zhang, M Zang, D Zhu, Y Bi
    Nat Commun, 2019-07-22;10(1):3254.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  31. c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies
    Authors: JH Bernink, Y Ohne, MBM Teunissen, J Wang, J Wu, L Krabbendam, C Guntermann, R Volckmann, J Koster, S van Tol, I Ramirez, Y Shrestha, MA de Rie, H Spits, X Romero Ros, AA Humbles
    Nat. Immunol., 2019-07-01;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  32. Type 1-programmed dendritic cells drive antigen-specific latency reversal and immune elimination of persistent HIV-1
    Authors: J Kristoff, ML Palma, TM Garcia-Bat, C Shen, N Sluis-Crem, P Gupta, CR Rinaldo, RB Mailliard
    EBioMedicine, 2019-04-02;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells
    Authors: T Hochdörfer, C Winkler, K Pardali, J Mjösberg
    Eur. J. Immunol., 2019-03-28;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Cytokine-induced memory-like natural killer cells have enhanced function, proliferation, and in vivo expansion against ovarian cancer cells
    Authors: LD Uppendahl, M Felices, L Bendzick, C Ryan, B Kodal, P Hinderlie, KLM Boylan, APN Skubitz, JS Miller, MA Geller
    Gynecol. Oncol., 2019-01-15;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Eomesodermin controls a unique differentiation program in human IL-10 and IFN-? co-producing regulatory T-cells
    Authors: P Gruarin, S Maglie, M De Simone, B Häringer, C Vasco, V Ranzani, R Bosotti, JS Noddings, P Larghi, F Facciotti, ML Sarnicola, M Martinovic, MC Crosti, M Moro, RL Rossi, ME Bernardo, F Caprioli, F Locatelli, G Rossetti, S Abrignani, M Pagani, J Geginat
    Eur. J. Immunol., 2018-11-29;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Dysregulated NK cell PLC?2 signaling and activity in juvenile dermatomyositis
    Authors: AA Throm, JB Alinger, JT Pingel, AL Daugherty, LM Pachman, AR French
    JCI Insight, 2018-11-15;3(22):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators
    Authors: V Lagou, JE Garcia-Per, I Smets, L Van Horebe, M Vandebergh, L Chen, K Mallants, T Prezzemolo, K Hilven, S Humblet-Ba, M Moisse, P Van Damme, G Boeckxstae, P Bowness, B Dubois, J Dooley, A Liston, A Goris
    Cell Rep, 2018-10-16;25(3):798-810.e6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Induction of antiinflammatory purinergic signaling in activated human iNKT cells
    Authors: JC Yu, G Lin, JJ Field, J Linden
    JCI Insight, 2018-09-06;3(17):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. The localisation of the heparin binding sites of human and murine interleukin-12 within the carboxyterminal domain of the P40 subunit
    Authors: P Garnier, R Mummery, MJ Forster, B Mulloy, RV Gibbs, CC Rider
    Cytokine, 2018-05-10;110(0):159-168.
    Species: Human
    Sample Types: Complex Sample Type
    Applications: Bioassay
  40. The psoriasis-protective TYK2 I684S variant impairs IL-12 stimulated pSTAT4 response in skin-homing CD4+ and CD8+ memory T-cells
    Authors: C Enerbäck, C Sandin, S Lambert, M Zawistowsk, PE Stuart, D Verma, LC Tsoi, RP Nair, A Johnston, JT Elder
    Sci Rep, 2018-05-04;8(1):7043.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Activated pancreatic stellate cells inhibit NK cell function in the human pancreatic cancer microenvironment
    Authors: Q Huang, M Huang, F Meng, R Sun
    Cell. Mol. Immunol., 2018-04-08;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells
    Authors: KS Burrack, MA Huggins, E Taras, P Dougherty, CM Henzler, R Yang, S Alter, EK Jeng, HC Wong, M Felices, F Cichocki, JS Miller, GT Hart, AJ Johnson, SC Jameson, SE Hamilton
    Immunity, 2018-04-03;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  43. Natural Killer Cell Inhibition by HLA-E Molecules on Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelial Cells
    Authors: S Sugita, K Makabe, Y Iwasaki, S Fujii, M Takahashi
    Invest. Ophthalmol. Vis. Sci., 2018-04-01;59(5):1719-1731.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. The natural HLA ligandome of glioblastoma stem-like cells: antigen discovery for T cell-based immunotherapy
    Authors: MC Neidert, DJ Kowalewski, M Silginer, K Kapolou, L Backert, LK Freudenman, JK Peper, A Marcu, SS Wang, JS Walz, F Wolpert, HG Rammensee, R Henschler, K Lamszus, M Westphal, P Roth, L Regli, S Stevanovi?, M Weller, G Eisele
    Acta Neuropathol., 2018-03-20;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4
    Authors: JJ Gilchrist, A Rautanen, BP Fairfax, TC Mills, V Naranbhai, H Trochet, M Pirinen, E Muthumbi, S Mwarumba, P Njuguna, N Mturi, CL Msefula, EN Gondwe, JM MacLennan, SJ Chapman, ME Molyneux, JC Knight, CCA Spencer, TN Williams, CA MacLennan, JAG Scott, AVS Hill
    Nat Commun, 2018-03-09;9(1):1014.
    Species: Human
    Sample Types: Whole Blood
    Applications: Bioassay
  46. An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease
    Authors: AW Clarke, L Poulton, D Shim, D Mabon, D Butt, M Pollard, V Pande, J Husten, J Lyons, C Tian, AG Doyle
    MAbs, 2018-03-05;0(0):1-43.
    Species: Human
    Sample Types: Whole Blood
    Applications: Bioassay
  47. Early and late changes in natural killer cells in response to ledipasvir/sofosbuvir treatment
    Authors: L Golden-Mas, RH McMahan, MS Kriss, AL Kilgore, L Cheng, RJ Dran, A Wieland, HR Rosen
    Hepatol Commun, 2018-03-01;2(4):364-375.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. BTKCys481Serdrives ibrutinib resistance via ERK1/2, and protects BTKWild-TypeMYD88 mutated cells by a paracrine mechanism
    Authors: JG Chen, X Liu, M Munshi, L Xu, N Tsakmaklis, MG Demos, A Kofides, ML Guerrera, GG Chan, CJ Patterson, KE Meid, J Gustine, T Dubeau, P Severns, JJ Castillo, ZR Hunter, J Wang, SJ Buhrlage, NS Gray, SP Treon, G Yang
    Blood, 2018-03-01;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Pathogen recognition by NK cells amplifies the pro-inflammatory cytokine production of monocyte-derived DC via IFN-?
    Authors: T Oth, THPM Habets, WTV Germeraad, MI Zonneveld, GMJ Bos, J Vanderloch
    BMC Immunol., 2018-02-13;19(1):8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect
    Authors: M Felices, AJ Lenvik, R McElmurry, S Chu, P Hinderlie, L Bendzick, MA Geller, J Tolar, BR Blazar, JS Miller
    JCI Insight, 2018-02-08;3(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Mesenchymal stromal cells of the bone marrow and natural killer cells: cell interactions and cross modulation
    Authors: M Najar, M Fayyad-Kaz, N Meuleman, D Bron, H Fayyad-Kaz, L Lagneaux
    J Cell Commun Signal, 2018-01-19;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. A phase I clinical trial of RNF43 peptide-related immune cell therapy combined with low-dose cyclophosphamide in patients with advanced solid tumors
    Authors: Y Hijikata, T Okazaki, Y Tanaka, M Murahashi, Y Yamada, K Yamada, A Takahashi, H Inoue, J Kishimoto, Y Nakanishi, Y Oda, Y Nakamura, K Tani
    PLoS ONE, 2018-01-02;13(1):e0187878.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Interleukin-12-mediated expression of matrix metalloproteinases in human periodontal ligament fibroblasts involves in NF-kappaB activation
    Authors: L Miao, S Zhan, J Liu
    Biosci. Rep., 2017-11-21;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. IL-18 associated with lung lymphoid aggregates drives IFN? production in severe COPD
    Authors: E Briend, GJ Ferguson, M Mori, G Damera, K Stephenson, NA Karp, S Sethi, CK Ward, MA Sleeman, JS Erjefält, DK Finch
    Respir. Res., 2017-08-22;18(1):159.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Bilirubin suppresses Th17 immunity in colitis by upregulating CD39
    Authors: MS Longhi, M Vuerich, A Kalbasi, JE Kenison, A Yeste, E Csizmadia, B Vaughn, L Feldbrugge, S Mitsuhashi, B Wegiel, L Otterbein, A Moss, FJ Quintana, SC Robson
    JCI Insight, 2017-05-04;2(9):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. A functional DC cross talk promotes human ILC homeostasis in humanized mice
    Authors: S Lopez-Last, G Masse-Rans, O Fiquet, S Darche, N Serafini, Y Li, M Dusséaux, H Strick-Mar, JP Di Santo
    Blood Adv, 2017-04-06;1(10):601-614.
    Species: Human
    Sample Types: Whole Cells
  57. IL-33, IL-25, and TSLP induce a distinct phenotypic and activation profile in human type 2 innate lymphoid cells
    Authors: A Camelo, G Rosignoli, Y Ohne, RA Stewart, C Overed-Say, MA Sleeman, RD May
    Blood Adv, 2017-03-30;1(10):577-589.
    Species: Human
    Sample Types: Whole Cells
  58. Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations
    Authors: C Guntermann, A Piaia, ML Hamel, D Theil, T Rubic-Schn, A Del Rio-Es, L Dong, A Billich, K Kaupmann, J Dawson, K Hoegenauer, D Orain, S Hintermann, R Stringer, DD Patel, A Doelemeyer, M Deurinck, J Schümann
    JCI Insight, 2017-03-09;2(5):e91127.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Soluble IL-6R expressed by myeloid cells reduces tumor-specific Th1 differentation and drives tumor progression
    Authors: H Tsukamoto, K Fujieda, M Hirayama, T Ikeda, A Yuno, K Matsumura, D Fukuma, K Araki, H Mizuta, H Nakayama, S Senju, Y Nishimura
    Cancer Res, 2017-02-24;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. EBI3 regulates the NK cell response to mouse cytomegalovirus infection
    Authors: H Jensen, SY Chen, L Folkersen, GP Nolan, LL Lanier
    Proc. Natl. Acad. Sci. U.S.A, 2017-01-31;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Tonsillar CD56brightNKG2A+ NK cells restrict primary Epstein-Barr virus infection in B cells via IFN-?
    Authors: A Jud, M Kotur, C Berger, C Gysin, D Nadal, A Lünemann
    Oncotarget, 2017-01-24;8(4):6130-6141.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML
    Mol Ther Methods Clin Dev, 2016-12-07;3(0):16074.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: ELISA (Control)
  63. Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors.
    Authors: Roybal K, Williams J, Morsut L, Rupp L, Kolinko I, Choe J, Walker W, McNally K, Lim W
    Cell, 2016-09-29;167(2):419-432.e16.
    Species: Human
    Sample Types: Whole Cells
    Applications: CAR-T (Bioassay)
  64. Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations
    Authors: Y Wang, CS Ma, Y Ling, A Bousfiha, Y Camcioglu, S Jacquot, K Payne, E Crestani, R Roncagalli, A Belkadi, G Kerner, L Lorenzo, C Deswarte, M Chrabieh, E Patin, QB Vincent, I Müller-Fle, B Fleckenste, F Ailal, L Quintana-M, S Fraitag, MA Alyanakian, M Leruez-Vil, C Picard, A Puel, J Bustamante, S Boisson-Du, M Malissen, B Malissen, L Abel, A Hovnanian, LD Notarangel, E Jouanguy, SG Tangye, V Béziat, JL Casanova
    J. Exp. Med., 2016-09-19;213(11):2413-2435.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Innate lymphoid cells are expanded and functionally altered in chronic lymphocytic leukemia
    Authors: I de Weerdt, V van Hoeven, JM Munneke, S Endstra, T Hofland, MD Hazenberg, AP Kater
    Haematologica, 2016-08-04;101(11):e461-e464.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Interferon Alpha Induces Sustained Changes in NK Cell Responsiveness to Hepatitis B Viral Load Suppression In Vivo
    PLoS Pathog, 2016-08-03;12(8):e1005788.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Longitudinal multiparameter assay of lymphocyte interactions from onset by microfluidic cell pairing and culture
    Authors: Burak Dura
    Proc Natl Acad Sci USA, 2016-06-14;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  68. IL-1?, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs
    Authors: SM Bal, JH Bernink, M Nagasawa, J Groot, MM Shikhagaie, K Golebski, CM van Drunen, R Lutter, RE Jonkers, P Hombrink, M Bruchard, J Villaudy, JM Munneke, W Fokkens, JS Erjefält, H Spits, XR Ros
    Nat Immunol, 2016-04-25;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Identification of Four-Jointed Box 1 (FJX1)-Specific Peptides for Immunotherapy of Nasopharyngeal Carcinoma.
    Authors: Chai S, Yap Y, Foo Y, Yap L, Ponniah S, Teo S, Cheong S, Patel V, Lim K
    PLoS ONE, 2015-11-04;10(11):e0130464.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  70. EBI3 Downregulation Contributes to Type I Collagen Overexpression in Scleroderma Skin.
    Authors: Kudo H, Wang Z, Jinnin M, Nakayama W, Inoue K, Honda N, Nakashima T, Kajihara I, Makino K, Makino T, Fukushima S, Ihn H
    J Immunol, 2015-09-09;195(8):3565-73.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Evidence for eomesodermin-expressing innate-like CD8(+) KIR/NKG2A(+) T cells in human adults and cord blood samples.
    Authors: Jacomet F, Cayssials E, Basbous S, Levescot A, Piccirilli N, Desmier D, Robin A, Barra A, Giraud C, Guilhot F, Roy L, Herbelin A, Gombert J
    Eur J Immunol, 2015-05-20;45(7):1926-33.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  72. GIMAP GTPase family genes: potential modifiers in autoimmune diabetes, asthma, and allergy.
    Authors: Heinonen M, Laine A, Soderhall C, Gruzieva O, Rautio S, Melen E, Pershagen G, Lahdesmaki H, Knip M, Ilonen J, Henttinen T, Kere J, Lahesmaa R
    J Immunol, 2015-05-11;194(12):5885-94.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  73. STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function.
    Authors: Wilson R, Ives M, Rao G, Lau A, Payne K, Kobayashi M, Arkwright P, Peake J, Wong M, Adelstein S, Smart J, French M, Fulcher D, Picard C, Bustamante J, Boisson-Dupuis S, Gray P, Stepensky P, Warnatz K, Freeman A, Rossjohn J, McCluskey J, Holland S, Casanova J, Uzel G, Ma C, Tangye S, Deenick E
    J Exp Med, 2015-05-04;212(6):855-64.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  74. The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4.
    Authors: Ranzani, Valeria, Rossetti, Grazisa, Panzeri, Ilaria, Arrigoni, Alberto, Bonnal, Raoul J, Curti, Serena, Gruarin, Paola, Provasi, Elena, Sugliano, Elisa, Marconi, Maurizio, De Francesco, Raffaele, Geginat, Jens, Bodega, Beatrice, Abrignani, Sergio, Pagani, Massimil
    Nat Immunol, 2015-01-26;16(3):318-25.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells.
    Authors: Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, Hayashi N, Mandai M, Takahashi M
    Invest Ophthalmol Vis Sci, 2015-01-20;56(2):1051-62.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Direct and indirect effects of immune and central nervous system-resident cells on human oligodendrocyte progenitor cell differentiation.
    Authors: Moore C, Cui Q, Warsi N, Durafourt B, Zorko N, Owen D, Antel J, Bar-Or A
    J Immunol, 2014-12-10;194(2):761-72.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Bioassay
  77. MicroRNA-146a controls Th1-cell differentiation of human CD4+ T lymphocytes by targeting PRKCepsilon.
    Authors: Mohnle P, Schutz S, van der Heide V, Hubner M, Luchting B, Sedlbauer J, Limbeck E, Hinske L, Briegel J, Kreth S
    Eur J Immunol, 2014-11-27;45(1):260-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Survivin-specific T cell receptor targets tumor but not T cells.
    Authors: Arber C, Feng X, Abhyankar H, Romero E, Wu M, Heslop H, Barth P, Dotti G, Savoldo B
    J Clin Invest, 2014-11-21;125(1):157-68.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy.
    Authors: Lam, Sharon, Sung, Julia, Cruz, Conrad, Castillo-Caro, Paul, Ngo, Minhtran, Garrido, Carolina, Kuruc, Joann, Archin, Nancie, Rooney, Cliona, Margolis, David, Bollard, Catherin
    Mol Ther, 2014-11-04;23(2):387-95.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  80. The regulation and role of c-FLIP in human Th cell differentiation.
    Authors: Kylaniemi M, Kaukonen R, Myllyviita J, Rasool O, Lahesmaa R
    PLoS ONE, 2014-07-14;9(7):e102022.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  81. IL-1beta promotes the differentiation of polyfunctional human CCR6+CXCR3+ Th1/17 cells that are specific for pathogenic and commensal microbes.
    Authors: Duhen T, Campbell D
    J Immunol, 2014-06-02;193(1):120-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Combinatorial flexibility of cytokine function during human T helper cell differentiation.
    Authors: Touzot M, Grandclaudon M, Cappuccio A, Satoh T, Martinez-Cingolani C, Servant N, Manel N, Soumelis V
    Nat Commun, 2014-05-28;5(0):3987.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.
    Authors: Kofler D, Marson A, Dominguez-Villar M, Xiao S, Kuchroo V, Hafler D
    J Clin Invest, 2014-05-08;124(6):2513-22.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  84. Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells.
    Authors: Kongsbak M, von Essen M, Boding L, Levring T, Schjerling P, Lauritsen J, Woetmann A, Odum N, Bonefeld C, Geisler C
    PLoS ONE, 2014-05-02;9(5):e96695.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  85. Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients.
    Authors: Teunissen M, Munneke J, Bernink J, Spuls P, Res P, Te Velde A, Cheuk S, Brouwer M, Menting S, Eidsmo L, Spits H, Hazenberg M, Mjosberg J
    J Invest Dermatol, 2014-03-21;134(9):2351-60.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Manipulating the expression of chemokine receptors enhances delivery and activity of cytokine-induced killer cells.
    Authors: Zou Y, Li F, Hou W, Sampath P, Zhang Y, Thorne S
    Br J Cancer, 2014-03-18;110(8):1992-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  87. A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist.
    Authors: Gresnigt M, Bozza S, Becker K, Joosten L, Abdollahi-Roodsaz S, van der Berg W, Dinarello C, Netea M, Fontaine T, De Luca A, Moretti S, Romani L, Latge J, van de Veerdonk F
    PLoS Pathog, 2014-03-06;10(3):e1003936.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  88. The aryl hydrocarbon receptor is functionally upregulated early in the course ofvhuman T-cell activation.
    Authors: Prigent L, Robineau M, Jouneau S, Morzadec C, Louarn L, Vernhet L, Fardel O, Sparfel L
    Eur J Immunol, 2014-02-18;44(5):1330-40.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  89. Flow cytometric detection of p38 MAPK phosphorylation and intracellular cytokine expression in peripheral blood subpopulations from patients with autoimmune rheumatic diseases.
    Authors: Mavropoulos A, Bogdanos D, Liaskos C, Orfanidou T, Simopoulou T, Zafiriou E, Sakkas L, Rigopoulou E
    J Immunol Res, 2014-02-03;2014(0):671431.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  90. TL1A induces TCR independent IL-6 and TNF-alpha production and growth of PLZF(+) leukocytes.
    Authors: Reichwald K, Jorgensen T, Tougaard P, Skov S
    PLoS ONE, 2014-01-08;9(1):e85793.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  91. High activities of BACE1 in brains with mild cognitive impairment.
    Authors: Cheng X, He P, Lee T, Yao H, Li R, Shen Y
    Am J Pathol, 2014-01-01;184(1):141-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  92. Neutrophil microparticles modulate cytokine production by natural killer cells.
    Authors: Pliyev B, Kalintseva M, Abdulaeva S, Yarygin K, Savchenko V
    Cytokine, 2013-12-16;65(2):126-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  93. Mapping the p53 transcriptome universe using p53 natural polymorphs.
    Authors: Wang, B, Niu, D, Lam, T H, Xiao, Z, Ren, E C
    Cell Death Differ, 2013-09-27;21(4):521-32.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  94. Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization.
    Authors: Hawkins R, Larjo A, Tripathi S, Wagner U, Luu Y, Lonnberg T, Raghav S, Lee L, Lund R, Ren B, Lahdesmaki H, Lahesmaa R
    Immunity, 2013-06-20;38(6):1271-84.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  95. Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands.
    Authors: Stephens G, Wang Q, Swerdlow B, Bhat G, Kolbeck R, Fung M
    Eur J Immunol, 2013-05-08;43(7):1727-34.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  96. Interleukin-27 is a potent inhibitor of cis HIV-1 replication in monocyte-derived dendritic cells via a type I interferon-independent pathway.
    Authors: Chen, Qian, Swaminathan, Sanjay, Yang, De, Dai, Lue, Sui, Hongyan, Yang, Jun, Hornung, Ronald L, Wang, Yanmei, Huang, Da Wei, Hu, Xiaojun, Lempicki, Richard, Imamichi, Tomozumi
    PLoS ONE, 2013-03-20;8(3):e59194.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Anti-GM-CSF autoantibodies in patients with cryptococcal meningitis.
    Authors: Rosen L, Freeman A, Yang L, Jutivorakool K, Olivier K, Angkasekwinai N, Suputtamongkol Y, Bennett J, Pyrgos V, Williamson P, Ding L, Holland S, Browne S
    J Immunol, 2013-03-18;190(8):3959-66.
    Species: Human
    Sample Types: Plasma
    Applications: Bioassay
  98. Adiponectin modulates NK-cell function.
    Authors: Wilk S, Jenke A, Stehr J, Yang C, Bauer S, Goldner K, Kotsch K, Volk H, Poller W, Schultheiss H, Skurk C, Scheibenbogen C
    Eur J Immunol, 2013-03-01;43(4):1024-33.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Loss of methylation at the IFNG promoter and CNS-1 is associated with the development of functional IFN-gamma memory in human CD4(+) T lymphocytes.
    Authors: Dong J, Chang H, Ivascu C, Qian Y, Rezai S, Okhrimenko A, Cosmi L, Maggi L, Eckhardt F, Wu P, Sieper J, Alexander T, Annunziato F, Gossen M, Li J, Radbruch A, Thiel A
    Eur J Immunol, 2013-03-01;43(3):793-804.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  100. Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency.
    Authors: Mazerolles F, Picard C, Kracker S, Fischer A, Durandy A
    J Allergy Clin Immunol, 2013-02-10;131(4):1146-56, 1156.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  101. AAV2/IL-12 gene delivery into dendritic cells (DC) enhances CTL stimulation above other IL-12 applications: Evidence for IL-12 intracrine activity in DC.
    Authors: You C, Shi M, Liu Y, Cao M, Luo R, Hermonat P
    Oncoimmunology, 2012-09-01;1(6):847-855.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  102. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
    Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
    Nature, 2012-07-26;487(7408):505-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  103. Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS.
    Authors: Flanagan K, Fitzgerald K, Baker J
    PLoS ONE, 2012-07-06;7(7):e40443.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  104. Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A.
    Authors: Nielsen N, Odum N, Urso B, Lanier LL, Spee P
    PLoS ONE, 2012-02-22;7(2):e31959.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  105. Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis.
    Authors: Carrier Y, Ma HL, Ramon HE, Napierata L, Small C, O'Toole M, Young DA, Fouser LA, Nickerson-Nutter C, Collins M, Dunussi-Joannopoulos K, Medley QG
    J. Invest. Dermatol., 2011-09-01;131(12):2428-37.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  106. Analysis of CD16+CD56dim NK cells from CLL patients: evidence supporting a therapeutic strategy with optimized anti-CD20 monoclonal antibodies.
    Authors: Le Garff-Tavernier M, Decocq J, de Romeuf C, Parizot C, Dutertre CA, Chapiro E, Davi F, Debre P, Prost JF, Teillaud JL, Merle-Beral H, Vieillard V
    Leukemia, 2010-10-26;25(1):101-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  107. Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells.
    Authors: Ramirez JM, Brembilla NC, Sorg O, Chicheportiche R, Matthes T, Dayer JM, Saurat JH, Roosnek E, Chizzolini C
    Eur. J. Immunol., 2010-09-01;40(9):2450-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  108. NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs.
    Authors: Beziat V, Descours B, Parizot C, Debre P, Vieillard V
    PLoS ONE, 2010-08-06;5(8):e11966.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  109. Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC.
    Authors: Jindra C
    Eur J Immunol, 2010-02-01;40(2):321-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  110. Natural killer cell-mediated cytokine response among HIV-positive south Indians with pulmonary tuberculosis.
    Authors: Ramana Rao PV, Rajasekaran S, Raja A
    J. Interferon Cytokine Res., 2010-01-01;30(1):33-42.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  111. IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis.
    Authors: Reeves EP, Williamson M, Byrne B, Bergin DA, Smith SG, Greally P, O'Kennedy R, O'Neill SJ, McElvaney NG
    J. Immunol., 2009-12-21;184(3):1642-52.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  112. Phenotypical characterization of human Th17 cells unambiguously identified by surface IL-17A expression.
    Authors: Brucklacher-Waldert V, Steinbach K, Lioznov M, Kolster M, Holscher C, Tolosa E
    J. Immunol., 2009-11-01;183(9):5494-501.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  113. Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines.
    Authors: Witte K, Gruetz G, Volk HD, Looman AC, Asadullah K, Sterry W, Sabat R, Wolk K
    Genes Immun., 2009-10-01;10(8):702-14.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  114. Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis.
    Authors: De Jager W, Vastert SJ, Beekman JM, Wulffraat NM, Kuis W, Coffer PJ, Prakken BJ
    Arthritis Rheum., 2009-09-01;60(9):2782-93.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  115. Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells.
    Authors: Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G
    Circulation, 2009-03-02;119(10):1424-32.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  116. Fully functional NK cells after unrelated cord blood transplantation.
    Authors: Beziat V, Nguyen S, Lapusan S, Hervier B, Dhedin N, Bories D, Uzunov M, Boudifa A, Trebeden-Negre H, Norol F, Marjanovic Z, Marie JP, Vernant JP, Debre P, Rio B, Vieillard V
    Leukemia, 2009-01-08;23(4):721-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  117. Immunologic analysis of HIV-uninfected Taiwanese children with BCG-induced disease.
    Authors: Lee WI, Liang FC, Huang JL, Jaing TH, Wang CH, Lin TY, Huang YC, Huang WL, Jou R, Hsieh MY, Chia JH, Wu TL
    J. Clin. Immunol., 2008-12-13;29(3):319-29.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo.
    Authors: Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB
    AIDS Res. Hum. Retroviruses, 2008-03-01;24(3):453-62.
    Applications: ELISA (Standard)
  119. IL-24 modulates IFN-gamma expression in patients with tuberculosis.
    Authors: Wu B, Huang C, Kato-Maeda M, Hopewell PC, Daley CL, Krensky AM, Clayberger C
    Immunol. Lett., 2007-12-26;117(1):57-62.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  120. Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays.
    Authors: Pfleger C, Schloot N, ter Veld F
    J. Immunol. Methods, 2007-10-22;329(1):214-8.
    Applications: ELISA (Standard)
  121. Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients: role of CD94/NKG2A in control of cytokine secretion.
    Authors: de Matos CT, Berg L, Michaelsson J, Fellander-Tsai L, Karre K, Soderstrom K
    Immunology, 2007-05-22;122(2):291-301.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  122. Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.
    Authors: Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM
    Blood, 2007-02-08;109(10):4272-9.
    Applications: ELISA (Standard)
  123. HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1.
    Authors: Grivel JC, Elliott J, Lisco A, Biancotto A, Condack C, Shattock RJ, McGowan I, Margolis L, Anton P
    AIDS, 2007;21(10):1263-72.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  124. Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription.
    Authors: Ebert EC, Mehta V
    Cell. Immunol., 2006-08-17;241(1):7-13.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  125. Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines.
    Authors: Gounni Abdelilah S, Wellemans V, Agouli M, Guenounou M, Hamid Q, Beck LA, Lamkhioued B
    Clin. Immunol., 2006-06-16;120(2):220-31.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  126. IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production.
    Authors: Vaknin-Dembinsky A, Balashov K, Weiner HL
    J. Immunol., 2006-06-15;176(12):7768-74.
    Applications: ELISA (Specificity Testing)
  127. Human complete Stat-1 deficiency is associated with defective type I and II IFN responses in vitro but immunity to some low virulence viruses in vivo.
    Authors: Chapgier A, Wynn RF, Jouanguy E, Filipe-Santos O, Zhang S, Feinberg J, Hawkins K, Casanova JL, Arkwright PD
    J. Immunol., 2006-04-15;176(8):5078-83.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  128. Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL).
    Authors: Hanabuchi S, Watanabe N, Wang YH, Ito T, Shaw J, Cao W, Qin FX, Liu YJ
    Blood, 2006-01-05;107(9):3617-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  129. CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines.
    Authors: Dulos J, van der Vleuten MA, Kavelaars A, Heijnen CJ, Boots AM
    Arthritis Rheum., 2005-03-01;52(3):770-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  130. Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma.
    Authors: Radstake TR, Roelofs MF, Jenniskens YM, van Riel PL, Barrera P
    Arthritis Rheum., 2004-12-01;50(12):3856-65.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  131. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways.
    Authors: Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R
    J. Immunol., 2004-09-01;173(5):3482-91.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  132. A novel form of complete IL-12/IL-23 receptor beta1 deficiency with cell surface-expressed nonfunctional receptors.
    Authors: Fieschi C, Bosticardo M, de Beaucoudrey L, Boisson-Dupuis S, Feinberg J, Santos OF, Bustamante J, Levy J, Candotti F, Casanova JL
    Blood, 2004-06-03;104(7):2095-101.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  133. Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines.
    Authors: Copeland S, Siddiqui J, Remick D
    J. Immunol. Methods, 2004-01-01;284(1):99-106.
    Applications: ELISA (Standard)
  134. APC-independent activation of NK cells by the Toll-like receptor 3 agonist double-stranded RNA.
    Authors: Schmidt KN, Leung B, Kwong M, Zarember KA, Satyal S, Navas TA, Wang F, Godowski PJ
    J. Immunol., 2004-01-01;172(1):138-43.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  135. BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone.
    Authors: Moreaux J, Legouffe E, Jourdan E, Quittet P, Reme T, Lugagne C, Moine P, Rossi JF, Klein B, Tarte K
    Blood, 2003-12-04;103(8):3148-57.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  136. In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment.
    Authors: Durali D, de Goer de Herve MG, Giron-Michel J, Azzarone B, Delfraissy JF, Taoufik Y
    Blood, 2003-07-31;102(12):4084-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  137. Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virus.
    Authors: Favre D, Blouin V, Provost N, Spisek R, Porrot F, Bohl D, Marme F, Cherel Y, Salvetti A, Hurtrel B, Heard JM, Riviere Y, Moullier P
    J. Virol., 2002-11-01;76(22):11605-11.
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  138. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.
    Authors: Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, Pflanz S, Zhang R, Singh KP, Vega F, To W, Wagner J, O&amp;apos;Farrell AM, McClanahan T, Zurawski S, Hannum C, Gorman D, Rennick DM, Kastelein RA, de Waal Malefyt R, Moore KW
    J. Immunol., 2002-06-01;168(11):5699-708.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  139. Cutting edge: immune cells as sources and targets of the IL-10 family members?
    Authors: Wolk K, Kunz S, Asadullah K, Sabat R
    J. Immunol., 2002-06-01;168(11):5397-402.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

FAQs

  1. What is the difference between Recombinant Human IL-12 Protein (Catalog # 219-IL) and Recombinant Human Il-12 (linked heterodimer) Protein (Catalog # 10018-IL?

    • The Recombinant Human IL-12 Protein (Catalog # 219-IL), expressed in Sf 21 cells, is a disulfide-linked homodimer consisting of the p35 and p40 subunits. The subunits can be separated under reducing conditions. The Recombinant Human IL-12 (linked heterodimer) Protein (Catalog # 10018-IL), expressed in HEK293 cells, is a chimeric protein consisting of the p35 and p40 subunits connected by a linker. These two subunits cannot be separated.

  2. Human IL-23 and Human IL-12 share a p40 subunit.  Why is the predicted molecular weight for the p40 subunit 36.5 kDa in the Recombinant Human IL-23 Protein (Catalog # 1290-IL), while the predicted molecular weight for the p40 subunit is 34.7 kDa for the Recombinant Human IL-12 Protein  (Catalog # 219-IL)?

    • The Recombinant Human IL-23 Protein (Catalog # 1290-IL) and Recombinant Human IL-12 Protein (Catalog # 219-IL) p40 subunits share the same p40 sequence, Ile23-Ser328 (Accession # P29460).  However, the p40 subunit for Recombinant Human IL-23 (Catalog # 1290-IL) also contains a portion of the GS linker that remains after cleaving p40 subunit from the p19 subunit, so its predicted molecular is slightly larger (36.5 kDa) compared to that of the Recombinant Human IL-12 Protein (Catalog # 219-IL; 34.7 kDa).  Please see the product-specific page for detailed sequence information.

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Average Rating: 4.5 (Based on 2 Reviews)

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Recombinant Human IL-12 Protein
By Lana Jagannathan on 08/26/2024
Application: Primary immune cell survival signal and stimulation
Reason for Rating: We have reliably used R&D IL-12 to enhance our primary T cell stimulation procedure. We have not tried competitor IL-12 but have found that R&D's can be pricier than others, which is the only reason I gave it 4 stars rather than 5.
Other Recombinant Human IL-12 Protein 219-IL
Recombinant Human IL-12 Protein
By Anonymous on 02/27/2023
Application: Stem/Immune cell maintenance or differentiation