Home / IL-6 / Recombinant Human IL-6 Protein

Recombinant Human IL-6 Protein

Catalog #: 206-IL
373 Citations 26 Reviews Datasheet / COA / SDS
GMP Version Available: 206-GMP
GMP

Carrier Free

Catalog # Availability Size / Price Qty
206-IL-001MG/CF
206-IL-050/CF
206-IL-200/CF
206-IL-025/CF

With Carrier

Catalog # Availability Size / Price Qty
206-IL-010
206-IL-050
206-IL-200
206-IL-01M
Best Seller
Recombinant Human IL‑6 Protein SEC-MALS.
4 Images
Product Details
Citations (373)
FAQs
Supplemental Products
Reviews (26)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human IL-6 Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using T1165.85.2.1 mouse plasmacytoma cells. Nordan, R.P. et al. (1987) J. Immunol. 139:813. The ED50 for this effect is 0.2-0.8 ng/mL.
Source
E. coli-derived human IL-6 protein
Pro29-Met212
Accession #
P05231.1
N-terminal Sequence
Analysis
Pro29
Predicted Molecular Mass
20.9 kDa

Product Datasheets

You must select a language.

x

206-IL (with carrier)

Product Datasheet
COA
SDS

You must select a language.

x

206-IL/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

206-IL

Formulation Lyophilized from a 0.2 μm filtered solution in PBS and NaCl with BSA as a carrier protein.
Reconstitution Reconstitute at 100-200 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

206-IL/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS and NaCl.
Reconstitution Reconstitute at 100-200 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

SEC-MALS View Larger

Recombinant Human IL-6 (Catalog # 206-IL) has a molecular weight (MW) of 23.1 kDa as analyzed by SEC-MALS, suggesting that this protein is a monomer.  MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation).

Bioactivity Recombinant Human IL-6 Protein Bioactivity View Larger

Recombinant Human IL-6 (Catalog # 206-IL) stimulates cell proliferation of the T1165.85.2.1 mouse plasmacytoma cell line. The ED50 for this effect is 0.2-0.8 ng/mL.

SDS-PAGE Recombinant Human IL-6 Protein SDS-PAGE View Larger

1 μg/lane of Recombinant Human IL-6 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 21 kDa.

Bioactivity View Larger

Equivalent bioactivity of GMP (206-GMP), Animal-Free (AFL206), and RUO (Catalog # 206-IL) grades of Recombinant Human IL-6 as measured in cell proliferation assay (orange, green, red, respectively).

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background: IL-6

Interleukin-6 (IL-6) is a pleiotropic, alpha -helical, 22-28 kDa phosphorylated and variably glycosylated cytokine that plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression (1-5). Mature human IL-6 is 183 amino acids (aa) in length and shares 39% aa sequence identity with mouse and rat IL-6 (6). Alternative splicing generates several isoforms with internal deletions, some of which exhibit antagonistic properties (7-10). IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R alpha) and a signal transducing subunit (gp130). IL-6 binds to IL-6 R alpha, triggering IL-6 R alpha association with gp130 and gp130 dimerization (11). gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM (12). Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage (5). In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha (5). Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 R alpha is predominantly restricted to hepatocytes, monocytes, and resting lymphocytes (2, 5). Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 R alpha but not from other cytokines that use gp130 as a co-receptor (5, 13). IL-6, along with TNF-alpha and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease (1-5). When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis (1, 2, 5). IL-6 can also function as an anti-inflammatory molecule, as in skeletal muscle where it is secreted in response to exercise (2). In addition, it enhances hematopoietic stem cell proliferation and the differentiation of Th17 cells, memory B cells, and plasma cells (1, 14).

References
  1. Mansell, A. and B.J. Jenkins (2013) Cytokine Growth Factor Rev. 24:249.
  2. Schuett, H. et al. (2009) Thromb. Haemost. 102:215.
  3. Erta, M. et al. (2012) Int. J. Biol. Sci. 8:1254.
  4. Garbers, C. et al. (2012) Cytokine Growth Factor Rev. 23:85.
  5. Mihara, M. et al. (2012) Clin. Sci. (Lond.) 122:143.
  6. Hirano, T. et al. (1986) Nature 324:73.
  7. Kestler, D.P. et al. (1995) Blood 86:4559.
  8. Kestler, D.P. et al. (1999) Am. J. Hematol. 61:169.
  9. Bihl, M.P. et al. (2002) Am. J. Respir. Cell Mol. Biol. 27:48.
  10. Alberti, L. et al. (2005) Cancer Res. 65:2.
  11. Murakami, M. et al. (1993) Science 260:1808.
  12. Muller-Newen, G. (2003) Sci. STKE 2003:PE40.
  13. Mitsuyama, K. et al. (2006) Clin. Exp. Immunol. 143:125.
  14. Cerutti, A. et al. (1998) J. Immunol. 160:2145.
Long Name
Interleukin 6
Entrez Gene IDs
3569 (Human); 16193 (Mouse); 24498 (Rat); 399500 (Porcine); 280826 (Bovine); 403985 (Canine); 102138971 (Cynomolgus Monkey); 100034196 (Equine); 493687 (Feline); 463288 (Primate); 100008733 (Rabbit)
Alternate Names
B-cell differentiation factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CTL differentiation factor ; HSF; hybridoma growth factor; IFNB2; IFN-beta-2; IL6; IL-6; Interferon beta-2; interleukin 6 (interferon, beta 2); interleukin BSF-2; interleukin-6; MGI-2A

Citations for Recombinant Human IL-6 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

373 Citations: Showing 1 - 10
Filter your results:

Filter by:

  1. STAT3 Protein-Protein Interaction Analysis Finds P300 as a Regulator of STAT3 and Histone 3 Lysine 27 Acetylation in Pericytes
    Authors: Kundu, G;Ghasemi, M;Yim, S;Rohil, A;Xin, C;Ren, L;Srivastava, S;Akinfolarin, A;Kumar, S;Srivastava, GP;Sabbisetti, VS;Murugaiyan, G;Ajay, AK;
    Biomedicines
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Paracrine Activation of STAT3 Drives GM-CSF Expression in Breast Carcinoma Cells, Generating a Symbiotic Signaling Network with Breast Carcinoma-Associated Fibroblasts
    Authors: Osuala, KO;Chalasani, A;Aggarwal, N;Ji, K;Moin, K;
    Cancers
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Dual therapeutic targeting of MYC and JUNB transcriptional programs for enhanced anti-myeloma activity
    Authors: Lind, J;Aksoy, O;Prchal-Murphy, M;Fan, F;Fulciniti, M;Stoiber, D;Bakiri, L;Wagner, EF;Zwickl-Traxler, E;Sattler, M;Kollmann, K;Vallet, S;Podar, K;
    Blood cancer journal
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. The Regulation of MicroRNA-21 by Interleukin-6 and Its Role in the Development of Fibrosis in Endometriotic Lesions
    Authors: Ochoa Bernal, MA;Song, Y;Joshi, N;Burns, GW;Paul, EN;Vegter, E;Hrbek, S;Sempere, LF;Fazleabas, AT;
    International journal of molecular sciences
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Human liver sinusoidal endothelial cells support the development of functional human pluripotent stem cell-derived Kupffer cells
    Authors: Kent, GM;Atkins, MH;Lung, B;Nikitina, A;Fernandes, IM;Kwan, JJ;Andrews, TS;MacParland, SA;Keller, GM;Gage, BK;
    Cell reports
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Targeting IL-6 trans-signalling by sgp130Fc attenuates severity in SARS-CoV-2 -infected mice and reduces endotheliopathy
    Authors: Rodríguez-Hernández, MÁ;Baena-Bustos, M;Carneros, D;Zurita-Palomo, C;Muñoz-Pinillos, P;Millán, J;Padillo, FJ;Smerdou, C;von Kobbe, C;Rose-John, S;Bustos, M;
    EBioMedicine
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Unravelling heterogeneous effects of cancer?associated fibroblasts on poor prognosis markers in breast cancer EM?G3 cell line: In vitro?targeted treatment (anti?IL-6, anti?VEGF-A, anti?MFGE8) based on transcriptomic profiling
    Authors: Urban, L;Novák, Š;?oma, M;Dvo?ánková, B;Lacina, L;Šáchová, J;Hradilová, M;Svato?ová, P;Kolá?, M;Strnad, H;B?ezinová, J;Smetana, K;Gál, P;Szabo, P;
    Oncology reports
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Interleukin-6 Induces Stem Cell Propagation through Liaison with the Sortilin-Progranulin Axis in Breast Cancer
    Authors: Berger, K;Persson, E;Gregersson, P;Ruiz-Martínez, S;Jonasson, E;Ståhlberg, A;Rhost, S;Landberg, G;
    Cancers
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Nanoparticles of Lactiplantibacillus plantarum K8 Reduce Staphylococcus aureus Respiratory Infection and Tumor Necrosis Factor Alpha- and Interferon Gamma-Induced Lung Inflammation
    Authors: Hong, J;Son, M;Sin, J;Kim, H;Chung, DK;
    Nutrients
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: ELISA Control
  10. Disrupting cellular memory to overcome drug resistance
    Authors: Harmange, G;Hueros, RAR;Schaff, DL;Emert, B;Saint-Antoine, M;Kim, LC;Niu, Z;Nellore, S;Fane, ME;Alicea, GM;Weeraratna, AT;Simon, MC;Singh, A;Shaffer, SM;
    Nature communications
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Identification of HHT-9041P1: A novel potent and selective JAK1 inhibitor in a rat model of rheumatoid arthritis
    Authors: Zhang, X;Xu, X;Chen, J;Wang, G;Li, Q;Li, M;Lu, J;
    International immunopharmacology
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. TIM-3 Expression and M2 Polarization of Macrophages in the TGF?-Activated Tumor Microenvironment in Colorectal Cancer
    Authors: Katagata, M;Okayama, H;Nakajima, S;Saito, K;Sato, T;Sakuma, M;Fukai, S;Endo, E;Sakamoto, W;Saito, M;Saze, Z;Momma, T;Mimura, K;Kono, K;
    Cancers
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  13. Progressively enhancing stemness of adoptively transferred T cells with PI3K? blockade improves metabolism and anti-tumor immunity
    Authors: Rangel Rivera, GO;Dwyer, CJ;Knochelmann, HM;Smith, AS;Aksoy, BA;Cole, AC;Wyatt, MM;Kumaresan, S;Thaxton, JE;Lesinski, GB;Paulos, CM;
    Cancer research
    Species: Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Factors Influencing Marker Expressions of Cultured Human Cord Blood-Derived Mast Cells
    Authors: Alimohammadi, S;Masuda-Kuroki, K;Szöll?si, AG;Di Nardo, A;
    International journal of molecular sciences
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. IL-6 trans-signaling in a humanized mouse model of scleroderma
    Authors: Odell, ID;Agrawal, K;Sefik, E;Odell, AV;Caves, E;Kirkiles-Smith, NC;Horsley, V;Hinchcliff, M;Pober, JS;Kluger, Y;Flavell, RA;
    Proceedings of the National Academy of Sciences of the United States of America
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. TNF? induced by DNA-sensing in macrophage compromises retinal pigment epithelial (RPE) barrier function
    Authors: Twarog, M;Schustak, J;Xu, Y;Coble, M;Dolan, K;Esterberg, R;Huang, Q;Saint-Geniez, M;Bao, Y;
    Scientific reports
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver disease
    Authors: Vaikunthanathan, T;Landmann, E;Correa, DM;Romano, M;Trevelin, SC;Peng, Q;Crespo, E;Corrado, M;Lozano, JJ;Pearce, EL;Perpinan, E;Zoccarato, A;Siew, L;Edwards-Hicks, J;Khan, R;Luu, NT;Thursz, MR;Newsome, PN;Martinez-Llordella, M;Shah, N;Lechler, RI;Shah, AM;Sanchez-Fueyo, A;Lombardi, G;Safinia, N;
    EBioMedicine
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Plug-and-play protein biosensors using aptamer-regulated in vitro transcription
    Authors: Lee, H;Xie, T;Yu, X;Schaffter, SW;Schulman, R;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  19. IMT504 protects beta cells against apoptosis and maintains beta cell identity, without modifying proliferation
    Authors: Converti, A;Bianchi, MS;Martinez, MD;Montaner, AD;Lux-Lantos, V;Bonaventura, MM;
    Physiological reports
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts
    Authors: A Di Nardo, YL Chang, S Alimohamma, K Masuda-Kur, Z Wang, K Sriram, PA Insel
    Cell Reports, 2023-04-28;42(5):112453.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Extending the dynamic range of biomarker quantification through molecular equalization
    Authors: Newman, S;Wilson, B;Mamerow, D;Wollant, B;Nyein, H;Rosenberg-Hasson, Y;Maecker, H;Eisenstein, M;Soh, H;
    bioRxiv
    Species: Human
    Sample Types: Serum
    Applications: Bioassay
  22. IL-1 Generated by Oral Squamous Cell Carcinoma Stimulates Tumor-Induced and RANKL-Induced Osteoclastogenesis: A Possible Mechanism of Bone Resorption Induced by the Infiltration of Oral Squamous Cell Carcinoma
    Authors: Y Fukawa, K Kayamori, M Tsuchiya, T Ikeda
    International Journal of Molecular Sciences, 2022-12-30;24(1):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  23. Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses
    Authors: L Feige, T Kozaki, G Dias de Me, V Guillemot, F Larrous, F Ginhoux, H Bourhy
    Viruses, 2022-12-29;15(1):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Gene Expression Linked to Reepithelialization of Human Skin Wounds
    Authors: MS Ågren, T Litman, JO Eriksen, P Schjerling, M Bzorek, LMR Gjerdrum
    International Journal of Molecular Sciences, 2022-12-12;23(24):.
    Species: Human
    Sample Types: Whole Cells
    Applications: cell cutlure
  25. IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia
    Authors: X Liu, N Sato, T Yabushita, J Li, Y Jia, M Tamura, S Asada, T Fujino, T Fukushima, T Yonezawa, Y Tanaka, T Fukuyama, A Tsuchiya, S Shikata, H Iwamura, C Kinouchi, K Komatsu, S Yamasaki, T Shibata, AT Sasaki, J Schibler, M Wunderlich, E O'Brien, B Mizukawa, JC Mulloy, Y Sugiura, H Takizawa, T Shibata, K Miyake, T Kitamura, S Goyama
    Embo Molecular Medicine, 2022-12-01;0(0):e15631.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  26. A portable analog front-end system for label-free sensing of proteins using nanowell array impedance sensors
    Authors: M Tayyab, P Xie, MA Sami, H Raji, Z Lin, Z Meng, SR Mahmoodi, M Javanmard
    Scientific Reports, 2022-11-22;12(1):20119.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: ELISA Standard
  27. Improved Sendai viral system for reprogramming to naive pluripotency.
    Authors: Kunitomi A, Hirohata R, Arreola V, Osawa M, Kato T, Nomura M, Kawaguchi J, Hara H, Kusano K, Takashima Y, Takahashi K, Fukuda K, Takasu N, Yamanaka S
    Cell Rep Methods, 2022-10-17;2(11):100317.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells
    Authors: YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra
    Science Advances, 2022-08-24;8(34):eabn5522.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor
    Authors: AKO Rode, TB Buus, V Mraz, FAH Al-Jaberi, DV Lopez, SL Ford, S Hennen, IP Eliasen, IV Klewe, L Gharehdagh, A Dragan, MM Rosenkilde, A Woetmann, L Skov, N Ødum, CM Bonefeld, M Kongsbak-W, C Geisler
    Cells, 2022-08-19;11(16):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Stimulation
  30. Identification of a distal enhancer that determines the expression pattern of acute phase marker C-reactive protein
    Authors: MY Wang, CM Zhang, HH Zhou, ZB Ge, CC Su, ZH Lou, XY Zhang, TT Xu, SY Li, L Zhu, YL Zhou, Y Wu, SR Ji
    Oncogene, 2022-06-17;0(0):102160.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway
    Authors: A Dritsoula, L Dowsett, C Pilotti, MN O'Connor, SE Moss, J Greenwood
    Scientific Reports, 2022-03-22;12(1):4867.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma Cells
    Authors: P Sekhri, DK Ledezma, A Shukla, EE Sweeney, R Fernandes
    Cancers, 2022-03-11;14(6):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  33. Metabolic profiling of prostate cancer in skeletal microenvironments identifies G6PD as a key mediator of growth and survival
    Authors: J Whitburn, SR Rao, EV Morris, S Tabata, A Hirayama, T Soga, JR Edwards, Z Kaya, C Palmer, FC Hamdy, CM Edwards
    Science Advances, 2022-02-25;8(8):eabf9096.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer
    Authors: T Matsumoto, H Okayama, S Nakajima, K Saito, M Ito, A Kaneta, Y Kanke, H Onozawa, S Hayase, S Fujita, W Sakamoto, M Saito, Z Seze, T Momma, K Mimura, K Kono
    British Journal of Cancer, 2021-12-10;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Small molecule allosteric inhibitors of RORgammat block Th17-dependent inflammation and associated gene expression in vivo
    Authors: SA Saenz, A Local, T Carr, A Shakya, S Koul, H Hu, L Chourb, J Stedman, J Malley, LA D'Agostino, V Shanmugasu, J Malona, CE Schwartz, L Beebe, M Clements, G Rajaraman, J Cho, L Jiang, A Dubrovskiy, M Kreilein, R Shimanovic, LG Hamann, L Escoubet, JM Ellis
    PLoS ONE, 2021-11-09;16(11):e0248034.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Modeling In Vitro Osteoarthritis Phenotypes in a Vascularized Bone Model Based on a Bone-Marrow Derived Mesenchymal Cell Line and Endothelial Cells
    Authors: A Pirosa, EB Tankus, A Mainardi, P Occhetta, L Dönges, C Baum, M Rasponi, I Martin, A Barbero
    International Journal of Molecular Sciences, 2021-09-03;22(17):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. IL-27 Mediates PD-L1 Expression and Release by Human Mesothelioma Cells
    Authors: G Carbotti, B Dozin, S Martini, C Giordano, F Scordamagl, M Croce, G Filaci, S Ferrini, M Fabbi
    Cancers, 2021-08-09;13(16):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy
    Authors: AL Fisher, V Sangkhae, K Balušíková, NJ Palaskas, T Ganz, E Nemeth
    Nature Communications, 2021-06-29;12(1):4026.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
    Authors: LG Lima, S Ham, H Shin, EPZ Chai, ESH Lek, RJ Lobb, AF Müller, S Mathivanan, B Yeo, Y Choi, BS Parker, A Möller
    Nature Communications, 2021-06-10;12(1):3543.
    Species: Human
    Sample Types: Exosomes
    Applications: ELISA Capture
  40. An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism
    Authors: P Gonzalez-M, M Romano, H Yan, R Deshmukh, J Papoin, L Oburoglu, M Daumur, AS Dumé, I Phadke, C Mongellaz, X Qu, PN Bories, M Fontenay, X An, V Dardalhon, M Sitbon, VS Zimmermann, PG Gallagher, S Tardito, L Blanc, N Mohandas, N Taylor, S Kinet
    Cell Reports, 2021-02-02;34(5):108723.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Tissue-specific endothelial cell heterogeneity contributes to unequal inflammatory responses
    Authors: H Gunawardan, T Romero, N Yao, S Heidt, A Mulder, DA Elashoff, NM Valenzuela
    Scientific Reports, 2021-01-21;11(1):1949.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. IL?6 plays a crucial role in epithelial?mesenchymal transition and pro?metastasis induced by sorafenib in liver cancer
    Authors: KW Zhang, D Wang, H Cai, MQ Cao, YY Zhang, PY Zhuang, J Shen
    Oncology reports, 2021-01-07;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH
    Authors: J Dong, S Viswanatha, E Adami, BK Singh, SP Chothani, B Ng, WW Lim, J Zhou, M Tripathi, NSJ Ko, SG Shekeran, J Tan, SY Lim, M Wang, PM Lio, PM Yen, S Schafer, SA Cook, AA Widjaja
    Nature Communications, 2021-01-04;12(1):66.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality
    Authors: J Stebbing, G Sánchez Ni, M Falcone, S Youhanna, P Richardson, S Ottaviani, JX Shen, C Sommerauer, G Tiseo, L Ghiadoni, A Virdis, F Monzani, LR Rizos, F Forfori, A Avendaño-C, S De Marco, L Carrozzi, F Lena, PM Sánchez-Ju, LG Lacerenza, N Cesira, D Caldevilla, A Perrella, L Niccoli, LS Méndez, D Matarrese, D Goletti, YJ Tan, V Monteil, G Dranitsari, F Cantini, A Farcomeni, S Dutta, SK Burley, H Zhang, M Pistello, W Li, M Mas Romero, F Andrés Pre, RS Simón-Tale, R García-Mol, C Kutter, JH Felce, ZF Nizami, AG Miklosi, JM Penninger, F Menichetti, A Mirazimi, P Abizanda, VM Lauschke
    Sci Adv, 2021-01-01;0(0):.
    Species: Human
    Sample Types: Spheroid
    Applications: Spheroid Culture
  45. Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation
    Authors: A Dorronsoro, V Lang, I Ferrin, J Fernández-, L Zabaleta, E Pérez-Ruiz, P Sepúlveda, C Trigueros
    Scientific Reports, 2020-12-14;10(1):21853.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Mesenchymal stem cells promote chemoresistance by activating autophagy in intrahepatic cholangiocarcinoma
    Authors: L Gan, H Shen, X Li, Z Han, Y Jing, X Yang, M Wu, Y Xia
    Oncol Rep, 2020-11-06;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  47. Evidence that Maackia amurensis seed lectin (MASL) exerts pleiotropic actions on oral squamous cells to inhibit SARS-CoV-2 infection and COVID-19 disease progression
    Authors: SA Sheehan, KL Hamilton, EP Retzbach, P Balachandr, H Krishnan, P Leone, GS Goldberg
    Res Sq, 2020-10-23;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. The vitamin D analogue calcipotriol promotes an anti-tumorigenic phenotype of human pancreatic CAFs but reduces T cell mediated immunity
    Authors: L Gorchs, S Ahmed, C Mayer, A Knauf, C Fernández, M Svensson, R Heuchel, E Rangelova, P Bergman, H Kaipe
    Sci Rep, 2020-10-15;10(1):17444.
    Species: Human
    Sample Types: Reference Standard
  49. NF-&kappaB and pSTAT3 synergistically drive G6PD overexpression and facilitate sensitivity to G6PD inhibition in ccRCC
    Authors: Q Zhang, Z Yang, Y Ni, H Bai, Q Han, Z Yi, X Yi, YL Agbana, Y Kuang, Y Zhu
    Cancer Cell Int, 2020-10-06;20(0):483.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Time-dependent LPS exposure commands MSC immunoplasticity through TLR4 activation leading to opposite therapeutic outcome in EAE
    Authors: M Kurte, AM Vega-Lette, P Luz-Crawfo, F Djouad, D Noël, M Khoury, F Carrión
    Stem Cell Res Ther, 2020-09-25;11(1):416.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. A role for annexin A2 in scaffolding the peroxiredoxin 2-STAT3 redox relay complex
    Authors: D Talwar, J Messens, TP Dick
    Nature Communications, 2020-09-09;11(1):4512.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. The innate immunity protein IFITM3 modulates &gamma-secretase in Alzheimer's disease
    Authors: JY Hur, GR Frost, X Wu, C Crump, SJ Pan, E Wong, M Barros, T Li, P Nie, Y Zhai, JC Wang, J Tcw, L Guo, A McKenzie, C Ming, X Zhou, M Wang, Y Sagi, AE Renton, BT Esposito, Y Kim, KR Sadleir, I Trinh, RA Rissman, R Vassar, B Zhang, DS Johnson, E Masliah, P Greengard, A Goate, YM Li
    Nature, 2020-09-02;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation
    Authors: J Yan, SP Pandey, BJ Barnes, JR Turner, C Abraham
    Cell Rep, 2020-06-30;31(13):107820.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
    Authors: L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen
    Cell Stem Cell, 2020-06-19;27(1):125-136.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Thrombopoietin is required for full phenotype expression in a JAK2V617F transgenic mouse model of polycythemia vera
    Authors: JL Spivak, A Merchant, DM Williams, O Rogers, W Zhao, A Duffield, LS Resar, AR Moliterno, ZJ Zhao
    PLoS ONE, 2020-06-01;15(6):e0232801.
    Species: Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Diminished toll-like receptor response in febrile infection-related epilepsy syndrome (FIRES)
    Authors: MY Hsieh, JJ Lin, SH Hsia, JL Huang, KW Yeh, KW Chang, WI Lee
    Biomed J, 2020-05-29;0(0):.
    Species: Human
    Sample Types: Cells
    Applications: Bioassay
  57. Ultrasensitive digital quantification of cytokines and bacteria predicts septic shock outcomes
    Authors: MF Abas?yan?k, K Wolfe, H Van Phan, J Lin, B Laxman, SR White, PA Verhoef, GM Mutlu, B Patel, S Tay
    Nat Commun, 2020-05-25;11(1):2607.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Biallelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells
    Authors: J Kanasugi, I Hanamura, A Ota, S Karnan, VQ Lam, S Mizuno, M Wahiduzzam, ML Rahman, T Hyodo, H Konishi, S Tsuzuki, Y Hosokawa, A Takami
    Cancer Sci., 2020-04-09;111(5):1663-1675.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  59. Cancer-associated fibroblasts promote immunosuppression by inducing ROS-generating monocytic MDSCs in lung squamous cell carcinoma
    Authors: H Xiang, CP Ramil, J Hai, C Zhang, H Wang, AA Watkins, R Afshar, P Georgiev, MA Sze, XS Song, PJ Curran, M Cheng, JR Miller, D Sun, A Loboda, Y Jia, LY Moy, A Chi, PE Brandish
    Cancer Immunol Res, 2020-02-19;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Increasing the Medium Osmolarity Reduces the Inflammatory Status of Human OA Chondrocytes and Increases Their Responsiveness to GDF-5
    Authors: T Mang, S Lindemann, A Gigout
    Int J Mol Sci, 2020-01-14;21(2):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  61. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
    Authors: L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen
    Cell Stem Cell, 2020;27(1):125-136.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  62. 15-Keto prostaglandin E2 induces heme oxygenase-1 expression through activation of Nrf2 in human colon epithelial CCD 841 CoN cells
    Authors: JE Lee, X Zhong, JY Lee, YJ Surh, HK Na
    Arch. Biochem. Biophys., 2019-12-24;0(0):108162.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  63. miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer
    Authors: D Parashar, A Geethadevi, MR Aure, J Mishra, J George, C Chen, MK Mishra, A Tahiri, W Zhao, B Nair, Y Lu, LS Mangala, C Rodriguez-, G Lopez-Bere, AKS Camara, M Liang, JS Rader, R Ramchandra, M You, AK Sood, VN Kristensen, GB Mills, S Pradeep, P Chaluvally
    Cell Rep, 2019-12-24;29(13):4389-4406.e10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  64. Mycobacterium tuberculosis Lipoarabinomannan Activates Human Neutrophils via a TLR2/1 Mechanism Distinct from Pam3CSK4
    Authors: JS Hook, M Cao, K Weng, N Kinnare, JG Moreland
    J. Immunol., 2019-12-23;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: ELISA Standard
  65. Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen
    Authors: D De Silva, Z Zhang, Y Liu, JS Parker, C Xu, L Cai, GG Wang, HS Earp, YE Whang
    Sci Rep, 2019-12-09;9(1):18637.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  66. Tumor suppressor HIC1 is synergistically compromised by cancer-associated fibroblasts and tumor cells through the IL-6/pSTAT3 axis in breast cancer
    Authors: X Sun, Q Qu, Y Lao, M Zhang, X Yin, H Zhu, Y Wang, J Yang, J Yi, M Hao
    BMC Cancer, 2019-12-03;19(1):1180.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: ELISA Standard
  67. Hydrogel based protein biochip for parallel detection of biomarkers for diagnosis of a Systemic Inflammatory Response Syndrome (SIRS) in human serum
    Authors: A Stumpf, T Brandstett, J Hübner, J Rühe
    PLoS ONE, 2019-12-02;14(12):e0225525.
    Species: Human
    Sample Types: Serum
    Applications: ELISA Standard
  68. Anti-interleukin-6 receptor antibody treatment ameliorates postoperative adhesion formation
    Authors: N Uyama, H Tsutsui, S Wu, K Yasuda, E Hatano, XY Qin, S Kojima, J Fujimoto
    Sci Rep, 2019-11-26;9(1):17558.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  69. MicroRNA-29a Mitigates Subacromial Bursa Fibrosis in Rotator Cuff Lesion with Shoulder Stiffness
    Authors: JY Ko, WS Lian, TC Tsai, YS Chen, CK Hsieh, CW Kuo, FS Wang
    Int J Mol Sci, 2019-11-15;20(22):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  70. Potent anti-myeloma activity of the TOPK inhibitor OTS514 in pre-clinical models
    Authors: AT Stefka, D Johnson, S Rosebeck, JH Park, Y Nakamura, AJ Jakubowiak
    Cancer Med, 2019-11-12;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  71. The Link between Type III Reg and STAT3-Associated Cytokines in Inflamed Colonic Tissues
    Authors: X Xu, H Fukui, Y Ran, X Wang, Y Inoue, N Ebisudani, H Nishimura, T Tomita, T Oshima, J Watari, H Kiyama, H Miwa
    Mediators Inflamm., 2019-11-06;2019(0):7859460.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice
    Authors: Z Liu, GWD Easson, J Zhao, N Makki, N Ahituv, MJ Hilton, SY Tang, RS Gray
    PLoS Genet., 2019-10-25;15(10):e1008096.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations
    Authors: J Grajcarek, J Monlong, Y Nishinaka-, M Nakamura, M Nagai, S Matsuo, D Lougheed, H Sakurai, MK Saito, G Bourque, K Woltjen
    Nat Commun, 2019-10-24;10(1):4856.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals
    Authors: ER Wonderlich, K Subramania, B Cox, A Wiegand, C Lackman-Sm, MJ Bale, M Stone, R Hoh, MF Kearney, F Maldarelli, SG Deeks, MP Busch, RG Ptak, DA Kulpa
    PLoS Pathog., 2019-10-14;15(10):e1008074.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. HIF1alpha inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis
    Authors: C Liang, J Li, C Lu, D Xie, J Liu, C Zhong, X Wu, R Dai, H Zhang, D Guan, B Guo, B He, F Li, X He, W Zhang, BT Zhang, G Zhang, A Lu
    Nat Commun, 2019-10-08;10(1):4579.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  76. The Possible Role of Neutrophils in the Induction of Osteoclastogenesis
    Authors: CGJ Moonen, TJ de Vries, P Rijkschroe, PE Poubelle, EA Nicu, BG Loos
    J Immunol Res, 2019-09-15;2019(0):8672604.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  77. STAT3-inhibitory activity of sesquiterpenoids and diterpenoids from Curcuma phaeocaulis
    Authors: HJ Jang, HJ Lim, EJ Park, SJ Lee, S Lee, SW Lee, MC Rho
    Bioorg. Chem., 2019-09-10;93(0):103267.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Reciprocal regulation of miR-206 and IL-6/STAT3 pathway mediates IL6-induced gefitinib resistance in EGFR-mutant lung cancer cells
    Authors: Y Yang, W Wang, H Chang, Z Han, X Yu, T Zhang
    J. Cell. Mol. Med., 2019-09-10;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Glycan-Modified Melanoma-Derived Apoptotic Extracellular Vesicles as Antigen Source for Anti-Tumor Vaccination
    Authors: SK Horrevorts, DA Stolk, RV Ven, M Hulst, BVH Hof, S Duinkerken, MH Heineke, W Ma, SA Dusoswa, R Nieuwland, JJ Garcia-Val, AAV Loosdrecht, TD de Gruijl, SJV Vliet, Y van Kooyk
    Cancers (Basel), 2019-08-28;11(9):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia
    Authors: MD McKenzie, M Ghisi, EP Oxley, S Ngo, L Cimmino, C Esnault, R Liu, JM Salmon, CC Bell, N Ahmed, M Erlichster, MT Witkowski, GJ Liu, M Chopin, A Dakic, E Simankowic, G Pomilio, T Vu, P Krsmanovic, S Su, L Tian, TM Baldwin, DA Zalcenstei, L DiRago, S Wang, D Metcalf, RW Johnstone, BA Croker, GI Lancaster, AJ Murphy, SH Naik, SL Nutt, V Pospisil, T Schroeder, M Wall, MA Dawson, AH Wei, H de Thé, ME Ritchie, J Zuber, RA Dickins
    Cell Stem Cell, 2019-08-01;25(2):258-272.e9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  81. CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients
    Authors: M Nasri, M Ritter, P Mir, B Dannenmann, N Aghaallaei, D Amend, V Makaryan, Y Xu, B Fletcher, R Bernhard, I Steiert, K Hahnel, J Berger, I Koch, B Sailer, K Hipp, C Zeidler, M Klimiankou, B Bajoghli, DC Dale, K Welte, J Skokowa
    Haematologica, 2019-06-27;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3
    Authors: D Kim, R Chen, M Sheu, N Kim, S Kim, N Islam, EM Wier, G Wang, A Li, A Park, W Son, B Evans, V Yu, VP Prizmic, E Oh, Z Wang, J Yu, W Huang, NK Archer, Z Hu, N Clemetson, AM Nelson, A Chien, GA Okoye, LS Miller, G Ghiaur, S Kang, JW Jones, MA Kane, LA Garza
    Nat Commun, 2019-06-26;10(1):2811.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Lipocalin 2: A New Antimicrobial in Mast Cells
    Authors: YL Chang, Z Wang, S Igawa, JE Choi, T Werbel, A Di Nardo
    Int J Mol Sci, 2019-05-14;20(10):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  84. Metformin inhibits IL-6 signaling by decreasing IL-6R expression on multiple myeloma cells
    Authors: AK Mishra, D Dingli
    Leukemia, 2019-04-15;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  85. Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies
    Authors: B Mair, J Tomic, SN Masud, P Tonge, A Weiss, M Usaj, AHY Tong, JJ Kwan, KR Brown, E Titus, M Atkins, KSK Chan, L Munsie, A Habsid, H Han, M Kennedy, B Cohen, G Keller, J Moffat
    Cell Rep, 2019-04-09;27(2):599-615.e12.
    Species: Human
    Sample Types: cell culture
    Applications: Differentiation, Differentiation
  86. Type 1-programmed dendritic cells drive antigen-specific latency reversal and immune elimination of persistent HIV-1
    Authors: J Kristoff, ML Palma, TM Garcia-Bat, C Shen, N Sluis-Crem, P Gupta, CR Rinaldo, RB Mailliard
    EBioMedicine, 2019-04-02;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis
    Authors: C Wei, C Yang, S Wang, D Shi, C Zhang, X Lin, Q Liu, R Dou, B Xiong
    Mol. Cancer, 2019-03-30;18(1):64.
    Species: Human
    Sample Types: Whole Cells
  88. Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells
    Authors: T Hochdörfer, C Winkler, K Pardali, J Mjösberg
    Eur. J. Immunol., 2019-03-28;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  89. Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes
    Authors: S Sun, X Zhang, M Xu, F Zhang, F Tian, J Cui, Y Xia, C Liang, S Zhou, H Wei, H Zhao, G Wu, B Xu, X Liu, G Yang, Q Wang, L Zhang, Y Gong, C Shao, Y Zou
    Cell Death Dis, 2019-03-20;10(4):274.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  90. Effects of resveratrol on Th17 cell-related immune responses under tacrolimus-based immunosuppression
    Authors: KC Doh, BM Kim, KW Kim, BH Chung, CW Yang
    BMC Complement Altern Med, 2019-03-04;19(1):54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  91. The role of IL-36? and its regulation in eosinophilic inflammation in allergic rhinitis
    Authors: X Qin, M Liu, S Zhang, C Wang, T Zhang
    Cytokine, 2019-03-01;117(0):84-90.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  92. Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I
    Authors: M Suga, T Kondo, K Imamura, R Shibukawa, Y Okanishi, Y Sagara, K Tsukita, T Enami, M Furujo, K Saijo, Y Nakamura, M Osawa, MK Saito, S Yamanaka, H Inoue
    Stem Cell Res, 2019-02-12;36(0):101406.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  93. MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway
    Authors: H Xu, SJ Xu, SJ Xie, Y Zhang, JH Yang, WQ Zhang, MN Zheng, H Zhou, LH Qu
    Elife, 2019-02-08;8(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  94. SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors
    Authors: TA Ahmed, C Adamopoulo, Z Karoulia, X Wu, R Sachidanan, SA Aaronson, PI Poulikakos
    Cell Rep, 2019-01-02;26(1):65-78.e5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  95. An integration-free iPSC line (MUSIi008-A) derived from a patient with severe hemolytic anemia carrying compound heterozygote mutations in KLF1 gene for disease modeling
    Authors: P Potirat, M Wattanapan, V Viprakasit, P Kheolamai, S Issaragris
    Stem Cell Res, 2018-12-14;34(0):101344.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  96. Fungal metabolite (+)-terrein suppresses IL-6/sIL-6R-induced CSF1 secretion by inhibiting JAK1 phosphorylation in human gingival fibroblasts
    Authors: S Yamamoto, K Omori, H Mandai, M Nakayama, S Nakagawa, H Kobayashi, T Kunimine, H Yoshimura, K Sakaida, H Sako, S Ibaragi, T Yamamoto, H Maeda, S Suga, S Takashiba
    Heliyon, 2018-11-26;4(11):e00979.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Analysis of TNF-? and interleukin-6 in seroma of patients undergoing mastectomy with or without flap fixation: is there a predictive value for seroma formation and its sequelae?
    Authors: J van Bastel, R Granzier, LM van Roozen, SMJ van Kuijk, AV Lerut, G Beets, M Hadfoune, S Olde Damin, YLJ Vissers
    Surg Oncol, 2018-11-08;28(0):36-41.
    Species: Human
    Sample Types: Complex Sample Type
    Applications: ELISA (Standard)
  98. Functionalization-dependent effects of cellulose nanofibrils on tolerogenic mechanisms of human dendritic cells
    Authors: S Tomi?, N Ili?, V Kokol, A Gruden-Mov, D Mihajlovi?, M Beki?, L Sofroni?-M, M ?oli?, D Vu?evi?
    Int J Nanomedicine, 2018-10-31;13(0):6941-6960.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Copy number variations and founder effect underlying complete IL-10R? deficiency in Portuguese kindreds
    Authors: F Charbit-He, B Bègue, A Sierra, S Hanein, MC Stolzenber, Z Li, S Pellegrini, N Garcelon, M Jeanpierre, B Neven, I Loge, C Picard, J Rosain, J Bustamante, M Le Lorc'h, B Pigneur, A Fernandes, F Rieux-Lauc, J Amil Dias, FM Ruemmele, N Cerf-Bensu
    PLoS ONE, 2018-10-26;13(10):e0205826.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  100. Aurora kinase and FGFR3 inhibition results in significant apoptosis in molecular subgroups of multiple myeloma
    Authors: U Painuly, V Ramakrishn, T Kimlinger, L Wellik, J Haug, W Gonsalves, L Bi, Z Huang, SV Rajkumar, S Kumar
    Oncotarget, 2018-10-02;9(77):34582-34594.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  101. Malignant Transformation of Human Bronchial Epithelial Cells Induced by Arsenic through STAT3/miR-301a/SMAD4 Loop
    Authors: M Zhong, Z Huang, L Wang, Z Lin, Z Cao, X Li, F Zhang, H Wang, Y Li, X Ma
    Sci Rep, 2018-09-05;8(1):13291.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  102. Abnormally Expressed JunB Transactivated by IL-6/STAT3 Signaling Promotes Uveal Melanoma Aggressiveness via Epithelial-mesenchymal Transition
    Authors: C Gong, J Shen, Z Fang, L Qiao, R Feng, X Lin, S Li
    Biosci. Rep., 2018-07-02;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  103. Iron overload impairs normal hematopoietic stem and progenitor cells through reactive oxygen species and shortens survival in myelodysplastic syndrome mice
    Authors: X Jin, X He, X Cao, P Xu, Y Xing, S Sui, L Wang, J Meng, W Lu, R Cui, H Ni, M Zhao
    Haematologica, 2018-06-14;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  104. Neutrophils induce macrophage anti-inflammatory reprogramming by suppressing NF-?B activation
    Authors: JA Marwick, R Mills, O Kay, K Michail, J Stephen, AG Rossi, I Dransfield, N Hirani
    Cell Death Dis, 2018-06-04;9(6):665.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  105. Synergistic effect of interleukin-17 and tumor necrosis factor-α on inflammatory response in hepatocytes through interleukin-6 dependent and independent pathways
    Authors: A Beringer, N Thiam, J Molle, B Bartosch, P Miossec
    Clin. Exp. Immunol., 2018-05-31;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  106. Anisakis pegreffii impacts differentiation and function of human dendritic cells
    Authors: C Napoletano, S Mattiucci, A Colantoni, F Battisti, IG Zizzari, H Rahimi, M Nuti, A Rughetti
    Parasite Immunol., 2018-05-01;0(0):e12527.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  107. A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development
    Authors: M Cesana, MH Guo, D Cacchiarel, L Wahlster, J Barragan, S Doulatov, LT Vo, B Salvatori, C Trapnell, K Clement, P Cahan, KM Tsanov, PM Sousa, B Tazon-Vega, A Bolondi, FM Giorgi, A Califano, JL Rinn, A Meissner, JN Hirschhorn, GQ Daley
    Cell Stem Cell, 2018-04-05;22(4):575-588.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  108. Microvasculature-directed thrombopoiesis in a 3D in vitro marrow microenvironment
    Authors: S Kotha, S Sun, A Adams, B Hayes, KT Phong, R Nagao, JA Reems, D Gao, B Torok-Stor, JA López, Y Zheng
    PLoS ONE, 2018-04-04;13(4):e0195082.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  109. Condition-dependent generation of aquaporin-4 antibodies from circulating B cells in neuromyelitis optica
    Authors: R Wilson, M Makuch, AK Kienzler, J Varley, J Taylor, M Woodhall, J Palace, MI Leite, P Waters, SR Irani
    Brain, 2018-04-01;141(4):1063-1074.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  110. Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes
    Authors: A Klaesson, K Grannas, T Ebai, J Heldin, B Koos, M Leino, D Raykova, J Oelrich, L Arngården, O Söderberg, U Landegren
    Sci Rep, 2018-03-29;8(1):5400.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Proximity Ligation Assay (PLA)
  111. Direct antiviral properties of TLR ligands against HBV replication in immune-competent hepatocytes
    Authors: J Lucifora, M Bonnin, L Aillot, F Fusil, S Maadadi, L Dimier, M Michelet, O Floriot, A Ollivier, M Rivoire, M Ait-Gougho, S Daffis, SP Fletcher, A Salvetti, FL Cosset, F Zoulim, D Durantel
    Sci Rep, 2018-03-29;8(1):5390.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  112. Discovery of a highly selective JAK3 inhibitor for the treatment of rheumatoid arthritis
    Authors: H Pei, L He, M Shao, Z Yang, Y Ran, D Li, Y Zhou, M Tang, T Wang, Y Gong, X Chen, S Yang, M Xiang, L Chen
    Sci Rep, 2018-03-27;8(1):5273.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  113. IL-37 inhibits invasion and metastasis in non-small cell lung cancer by suppressing the IL-6/STAT3 signaling pathway
    Authors: M Jiang, Y Wang, H Zhang, Y Ji, P Zhao, R Sun, C Zhang
    Thorac Cancer, 2018-03-25;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  114. Cytokine Profile of Human Abdominal Aortic Aneurysm: Involvement of JAK/STAT Pathway
    Authors: T Ohno, H Aoki, S Ohno, M Nishihara, A Furusho, S Hiromatsu, H Akashi, Y Fukumoto, H Tanaka
    Ann Vasc Dis, 2018-03-25;11(1):84-90.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  115. A novel mechanism of ?-irradiation-induced IL-6 production mediated by P2Y11 receptor in epidermal keratinocytes
    Authors: A Ohsaki, Y Miyano, R Tanaka, SI Tanuma, S Kojima, M Tsukimoto
    Biol. Pharm. Bull., 2018-03-16;0(0):.
    Applications: ELISA (Standard)
  116. Molecular transitions in early progenitors during human cord blood hematopoiesis
    Authors: S Zheng, E Papalexi, A Butler, W Stephenson, R Satija
    Mol. Syst. Biol., 2018-03-15;14(3):e8041.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  117. BTKCys481Serdrives ibrutinib resistance via ERK1/2, and protects BTKWild-TypeMYD88 mutated cells by a paracrine mechanism
    Authors: JG Chen, X Liu, M Munshi, L Xu, N Tsakmaklis, MG Demos, A Kofides, ML Guerrera, GG Chan, CJ Patterson, KE Meid, J Gustine, T Dubeau, P Severns, JJ Castillo, ZR Hunter, J Wang, SJ Buhrlage, NS Gray, SP Treon, G Yang
    Blood, 2018-03-01;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Interleukin-6/Stat3 signaling has an essential role in the host antimicrobial response to urinary tract infection
    Authors: CB Ching, S Gupta, B Li, H Cortado, N Mayne, AR Jackson, KM McHugh, B Becknell
    Kidney Int., 2018-02-21;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  119. A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials
    Authors: H Fraser, N Safinia, N Grageda, S Thirkell, K Lowe, LJ Fry, C Scottá, A Hope, C Fisher, R Hilton, D Game, P Harden, A Bushell, K Wood, RI Lechler, G Lombardi
    Mol Ther Methods Clin Dev, 2018-01-31;8(0):198-209.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  120. DDIT4 and Associated lncDDIT4 Modulate Th17 Differentiation through the DDIT4/TSC/mTOR Pathway
    Authors: F Zhang, G Liu, D Li, C Wei, J Hao
    J. Immunol., 2018-01-29;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Streamlined circular proximity ligation assay provides high stringency and compatibility with low-affinity antibodies
    Authors: R Jalili, J Horecka, JR Swartz, RW Davis, HHJ Persson
    Proc. Natl. Acad. Sci. U.S.A., 2018-01-16;0(0):.
    Applications: Bioassay
  122. Interleukin-6 promotes a sustained loss of endothelial barrier function via Janus kinase-mediated STAT3 phosphorylation and de novo protein synthesis
    Authors: H Alsaffar, N Martino, JP Garrett, AP Adam
    Am. J. Physiol., Cell Physiol., 2018-01-10;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  123. Zika viral infection and neutralizing human antibody response in a BLT humanized mouse model
    Authors: K Schmitt, P Charlins, M Veselinovi, L Kinner-Bib, S Hu, J Curlin, L Remling-Mu, KE Olson, T Aboellail, R Akkina
    Virology, 2018-01-06;515(0):235-242.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  124. EpCAM peptide-primed dendritic cell vaccination confers significant anti-tumor immunity in hepatocellular carcinoma cells
    Authors: YJ Choi, SJ Park, YS Park, HS Park, KM Yang, K Heo
    PLoS ONE, 2018-01-03;13(1):e0190638.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  125. Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes
    Authors: A Palau, AK Garz, J Diesch, A Zwick, R Malinverni, V Valero, K Lappin, R Casquero, A Lennartsso, J Zuber, T Navarro, KI Mills, KS Götze, M Buschbeck
    Oncotarget, 2017-12-01;8(70):115002-115017.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  126. G6PD promotes renal cell carcinoma proliferation through positive feedback regulation of p-STAT3
    Authors: Q Zhang, Z Yang, Q Han, H Bai, Y Wang, X Yi, Z Yi, L Yang, L Jiang, X Song, Y Kuang, Y Zhu
    Oncotarget, 2017-11-20;8(65):109043-109060.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  127. A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models
    Authors: GE Tyzack, CE Hall, CR Sibley, T Cymes, S Forostyak, G Carlino, IF Meyer, G Schiavo, SC Zhang, GM Gibbons, J Newcombe, R Patani, A Lakatos
    Nat Commun, 2017-10-27;8(1):1164.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  128. IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression
    Authors: Y Wang, JB Mumm, R Herbst, R Kolbeck, Y Wang
    J. Immunol., 2017-09-22;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  129. Genome-wide Mapping of Off-Target Events in Single-Stranded Oligodeoxynucleotide-Mediated Gene Repair Experiments
    Authors: S Radecke, K Schwarz, F Radecke
    Mol. Ther., 2017-09-15;26(1):115-131.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  130. The Stimulation of Macrophages with TLR Ligands Supports Increased IL-19 Expression in Inflammatory Bowel Disease Patients and in Colitis Models
    Authors: A Steinert, I Linas, B Kaya, M Ibrahim, A Schlitzer, P Hruz, K Radulovic, L Terraccian, AJ Macpherson, JH Niess
    J. Immunol., 2017-09-01;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  131. Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis
    Authors: NJ Palpant, Y Wang, B Hadland, RJ Zaunbreche, M Redd, D Jones, L Pabon, R Jain, J Epstein, WL Ruzzo, Y Zheng, I Bernstein, A Margolin, CE Murry
    Cell Rep, 2017-08-15;20(7):1597-1608.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  132. Mucin 2 silencing promotes colon cancer metastasis through interleukin-6 signaling
    Authors: HP Hsu, MD Lai, JC Lee, MC Yen, TY Weng, WC Chen, JH Fang, YL Chen
    Sci Rep, 2017-07-19;7(1):5823.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  133. miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A
    Authors: A Bott, N Erdem, S Lerrer, A Hotz-Wagen, C Breunig, K Abnaof, A Wörner, H Wilhelm, E Münsterman, A Ben-Baruch, S Wiemann
    Oncotarget, 2017-07-04;8(27):43897-43914.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  134. Prevalence and correlation of cytokine-specific autoantibodies with epidemiological factors and C-reactive protein in 8,972 healthy individuals: Results from the Danish Blood Donor Study
    Authors: JH von Steman, AS Rigas, LW Thørner, DGK Rasmussen, OB Pedersen, K Rostgaard, C Erikstrup, H Ullum, MB Hansen
    PLoS ONE, 2017-06-30;12(6):e0179981.
    Species: Human
    Sample Types: Plasma
    Applications: Control
  135. TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy
    Authors: J Ye, Y Wang, X Liu, L Li, A Opejin, EC Hsueh, H Luo, T Wang, D Hawiger, G Peng
    J. Immunol., 2017-06-26;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  136. Knockout of the Nogo-B Gene Attenuates Tumor Growth and Metastasis in Hepatocellular Carcinoma
    Authors: B Zhu, S Chen, X Hu, X Jin, Y Le, L Cao, Z Yuan, Z Lin, S Jiang, L Sun, L Yu
    Neoplasia, 2017-06-17;19(7):583-593.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  137. An activated Th17-prone T cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition
    Authors: E Forcade, K Paz, R Flynn, B Griesenaue, T Amet, W Li, L Liu, G Bakoyannis, D Jiang, HW Chu, M Lobera, J Yang, DS Wilkes, J Du, K Gartlan, GR Hill, KP MacDonald, EL Espada, P Blanco, JS Serody, J Koreth, CS Cutler, JH Antin, RJ Soiffer, J Ritz, S Paczesny, BR Blazar
    JCI Insight, 2017-06-15;2(12):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  138. ?2-adrenergic receptor-mediated in vitro regulation of human hepatic drug transporter expression by epinephrine
    Authors: A Mayati, A Moreau, C Denizot, B Stieger, Y Parmentier, O Fardel
    Eur J Pharm Sci, 2017-06-08;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  139. The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells
    Authors: J Geng, S Yu, H Zhao, X Sun, X Li, P Wang, X Xiong, L Hong, C Xie, J Gao, Y Shi, J Peng, RL Johnson, N Xiao, L Lu, J Han, D Zhou, L Chen
    Nat. Immunol., 2017-05-15;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  140. IL-1? transcriptionally activates hepcidin by inducing C/EBP? expression in hepatocytes
    Authors: Y Kanamori, M Murakami, M Sugiyama, O Hashimoto, T Matsui, M Funaba
    J. Biol. Chem., 2017-04-24;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  141. Maslinic acid suppresses the growth of human gastric cells by inducing apoptosis via inhibition of the interleukin-6 mediated Janus kinase/signal transducer and activator of transcription 3 signaling pathway
    Authors: D Wang, S Tang, Q Zhang
    Oncol Lett, 2017-04-21;13(6):4875-4881.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  142. In�vitro model of cerebral ischemia by using brain microvascular endothelial cells derived from human induced pluripotent stem cells
    Authors: Y Kokubu, T Yamaguchi, K Kawabata
    Biochem. Biophys. Res. Commun, 2017-03-21;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  143. Autophagy Impairment by Helicobacter pylori-induced Methylation Silencing of MAP1LC3Av1 Promotes Gastric Carcinogenesis
    Authors: JS Muhammad, S Nanjo, T Ando, S Yamashita, T Maekita, T Ushijima, Y Tabuchi, T Sugiyama
    Int. J. Cancer, 2017-03-14;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  144. Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9
    Authors: JA Schwartz, KL Clayton, S Mujib, H Zhang, AK Rahman, J Liu, FY Yue, E Benko, C Kovacs, MA Ostrowski
    J. Immunol, 2017-03-06;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  145. Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3
    Authors: H He, AE Kuriyan, CW Su, M Mahabole, Y Zhang, YT Zhu, HW Flynn, JM Parel, SC Tseng
    Sci Rep, 2017-03-02;7(0):43736.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  146. Reduced skeletal muscle secreted frizzled-related protein 3 is associated with inflammation and insulin resistance
    Authors: AS Pachori, M Madan, YO Nunez Lope, F Yi, C Meyer, AA Seyhan
    Obesity (Silver Spring), 2017-02-27;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  147. Soluble IL-6R expressed by myeloid cells reduces tumor-specific Th1 differentation and drives tumor progression
    Authors: H Tsukamoto, K Fujieda, M Hirayama, T Ikeda, A Yuno, K Matsumura, D Fukuma, K Araki, H Mizuta, H Nakayama, S Senju, Y Nishimura
    Cancer Res, 2017-02-24;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  148. Decitabine treatment sensitizes tumor cells to T-cell-mediated cytotoxicity in patients with myelodysplastic syndromes
    Authors: Z Zhang, Q He, Y Tao, J Guo, F Xu, LY Wu, YS Zhao, D Wu, LY Zhou, JY Su, LX Song, C Xiao, X Li, CK Chang
    Am J Transl Res, 2017-02-15;9(2):454-465.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  149. Vaccination targeting native receptors to enhance the function and proliferation of chimeric antigen receptor (CAR)-modified T cells
    Authors: M Tanaka, H Tashiro, B Omer, N Lapteva, J Ando, M Ngo, B Mehta, G Dotti, PR Kinchingto, AM Leen, C Rossig, CM Rooney
    Clin. Cancer Res, 2017-02-09;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  150. CGI-99 promotes breast cancer metastasis via autocrine interleukin-6 signaling
    Authors: C Lin, W Liao, Y Jian, Y Peng, X Zhang, L Ye, Y Cui, B Wang, X Wu, Z Xiong, S Wu, J Li, X Wang, L Song
    Oncogene, 2017-02-06;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  151. Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling
    Authors: R Adams, RJ Burnley, CR Valenzano, O Qureshi, C Doyle, S Lumb, M Del Carmen, R Griffin, D McMillan, RD Taylor, C Meier, P Mori, LM Griffin, U Wernery, J Kinne, S Rapecki, TS Baker, AD Lawson, M Wright, A Ettorre
    Sci Rep, 2017-01-30;7(0):37716.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  152. Radiation Induced Apoptosis of Murine Bone Marrow Cells Is Independent of Early Growth Response 1 (EGR1)
    Authors: KZ Oben, BW Gachuki, SS Alhakeem, MK McKenna, Y Liang, DK St Clair, VM Rangnekar, S Bondada
    PLoS ONE, 2017-01-12;12(1):e0169767.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  153. Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases
    Cell Death Dis, 2016-12-29;7(12):e2565.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  154. Environmental factor and inflammation-driven alteration of the total peripheral T-cell compartment in granulomatosis with polyangiitis
    Authors: Anja Kerstein
    J. Autoimmun, 2016-12-28;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  155. TGF-beta Affects the Differentiation of Human GM-CSF+ CD4+ T Cells in an Activation- and Sodium-Dependent Manner.
    Authors: Elias S, Schmidt A, Kannan V, Andersson J, Tegner J
    Front Immunol, 2016-12-23;7(0):603.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  156. Injury-Induced Senescence Enables In�Vivo Reprogramming in Skeletal Muscle
    Authors: Aurélie Chiche
    Cell Stem Cell, 2016-12-22;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  157. Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia
    Oncogene, 2016-12-19;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  158. Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling
    Sci Rep, 2016-12-19;6(0):39190.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  159. Effects of neuromyelitis optica-IgG at the blood-brain barrier in vitro
    Authors: Yukio Takeshita
    Neurol Neuroimmunol Neuroinflamm, 2016-12-19;4(1):e311.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  160. Structure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database
    Drug Des Devel Ther, 2016-12-15;10(0):4091-4100.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  161. G protein-coupled receptor 34 in ovarian granulosa cells of cattle: changes during follicular development and potential functional implications
    Authors: L J Spicer
    Domest. Anim. Endocrinol, 2016-12-11;59(0):90-99.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  162. A generic RNA pulsed DC based approach for developing therapeutic intervention against Nasopharyngeal Carcinoma
    Authors: Rajeev K Tyagi
    Hum Vaccin Immunother, 2016-11-30;0(0):0.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  163. Regulation and function of Bone Morphogenetic Protein signaling in colonic injury and inflammation
    Authors: Andrea Todisco
    Am. J. Physiol. Gastrointest. Liver Physiol., 2016-11-17;0(0):ajpgi.00169.2.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  164. The Analysis of CD83 Expression on Human Immune Cells Identifies a Unique CD83+-Activated T Cell Population
    Authors: Derek N J Hart
    J. Immunol., 2016-11-11;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  165. MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations
    Authors: Robert Sabat
    Mediators Inflamm., 2016-10-23;2016(0):4097574.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  166. Activated monocytes resist elimination by retinal pigment epithelium and downregulate their OTX2 expression via TNF-?
    Aging Cell, 2016-09-22;0(0):.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  167. Involvement of Spinal IL-6 Trans-Signaling in the Induction of Hyperexcitability of Deep Dorsal Horn Neurons by Spinal Tumor Necrosis Factor-Alpha
    J Neurosci, 2016-09-21;36(38):9782-91.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  168. Endothelial Cell Activation is Regulated by Epidermal Growth Factor-Like Domain 7 (Egfl7) during Inflammation
    J Biol Chem, 2016-09-20;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  169. Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue
    J Immunol, 2016-09-19;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  170. Cytokines TNF-?, IL-6, IL-17F, and IL-4 Differentially Affect Osteogenic Differentiation of Human Adipose Stem Cells.
    Authors: Angela P Bastidas-C, Astrid D Bakker, Behrouz Zandieh-D, Cornelis J Kleverlaa, Nathalie Bravenboe, Tim Forouzanf, Jenneke Klein-Nul
    Stem Cells International, 2016-09-07;0(0):1687-966X.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  171. Regulation of Polycystin-1 Function by Calmodulin Binding
    PLoS ONE, 2016-08-25;11(8):e0161525.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  172. Jak1-STAT3 signals are essential effectors of the USP6/TRE17 oncogene in tumorigenesis
    Cancer Res, 2016-07-20;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  173. The Human Antimicrobial Protein Bactericidal/Permeability-Increasing Protein (BPI) Inhibits the Infectivity of Influenza A Virus
    Authors: Olaf Pinkenburg
    PLoS ONE, 2016-06-06;11(6):e0156929.
    Species: Human
    Sample Types: Whole Cells
    Applications: ELISA (Standard)
  174. Expression of human gene coding ROR?T receptor depends on the Sp2 transcription factor
    Authors: Marcin Ratajewski
    J Leukoc Biol, 2016-06-02;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  175. Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7
    Authors: MM Halpert, V Konduri, D Liang, Y Chen, JB Wing, S Paust, JM Levitt, WK Decker
    Stem Cells Dev., 2016-05-02;25(10):774-87.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  176. A Novel IL6 Antibody Sensitizes Multiple Tumor Types to Chemotherapy Including Trastuzumab-Resistant Tumors.
    Authors: Zhong H, Davis A, Ouzounova M, Carrasco R, Chen C, Breen S, Chang Y, Huang J, Liu Z, Yao Y, Hurt E, Moisan J, Fung M, Tice D, Clouthier S, Xiao Z, Wicha M, Korkaya H, Hollingsworth R
    Cancer Res, 2016-01-07;76(2):480-90.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  177. Cryptococcus gattii Capsule Blocks Surface Recognition Required for Dendritic Cell Maturation Independent of Internalization and Antigen Processing.
    Authors: Huston S, Ngamskulrungroj P, Xiang R, Ogbomo H, Stack D, Li S, Timm-McCann M, Kyei S, Oykhman P, Kwon-Chung K, Mody C
    J Immunol, 2016-01-06;196(3):1259-71.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  178. Preferential Induction of the T Cell Auxiliary Signaling Molecule B7-H3 on Synovial Monocytes in Rheumatoid Arthritis
    Authors: BR Yoon, YH Chung, SJ Yoo, K Kawara, J Kim, IS Yoo, CG Park, SW Kang, WW Lee
    J. Biol. Chem, 2015-12-23;291(8):4048-57.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  179. Anthocyanin Extracted from Black Soybean Seed Coats Prevents Autoimmune Arthritis by Suppressing the Development of Th17 Cells and Synthesis of Proinflammatory Cytokines by Such Cells, via Inhibition of NF-kappaB.
    Authors: Min H, Kim S, Baek S, Woo J, Park J, Cho M, Lee J, Kwok S, Kim S, Park S
    PLoS ONE, 2015-11-06;10(11):e0138201.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  180. IL-6 Inhibits the Targeted Modulation of PDCD4 by miR-21 in Prostate Cancer.
    Authors: Dong B, Shi Z, Wang J, Wu J, Yang Z, Fang K
    PLoS ONE, 2015-08-07;10(8):e0134366.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  181. Cancer-testis antigen SLLP1 represents a promising target for the immunotherapy of multiple myeloma.
    Authors: Yousef S, Heise J, Lajmi N, Bartels K, Kroger N, Luetkens T, Atanackovic D
    J Transl Med, 2015-06-20;13(0):197.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  182. Interleukin-6 Stimulates Defective Angiogenesis.
    Authors: Gopinathan G, Milagre C, Pearce O, Reynolds L, Hodivala-Dilke K, Leinster D, Zhong H, Hollingsworth R, Thompson R, Whiteford J, Balkwill F
    Cancer Res, 2015-06-16;75(15):3098-107.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  183. Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy.
    Authors: Schumacher A, Denecke B, Braunschweig T, Stahlschmidt J, Ziegler S, Brandenburg L, Stope M, Martincuks A, Vogt M, Gortz D, Camporeale A, Poli V, Muller-Newen G, Brummendorf T, Ziegler P
    J Hematol Oncol, 2015-06-09;8(0):64.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  184. A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor beta Subunit, Glycoprotein 130.
    Authors: Hong S, Choi J, Lee S, Park Y, Park K, Lee J, Kim J, Gajulapati V, Goo J, Singh S, Lee K, Kim Y, Im S, Ahn S, Rose-John S, Heo T, Choi Y
    J Immunol, 2015-05-29;195(1):237-45.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  185. Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis.
    Authors: Ling Y, Cypowyj S, Aytekin C, Galicchio M, Camcioglu Y, Nepesov S, Ikinciogullari A, Dogu F, Belkadi A, Levy R, Migaud M, Boisson B, Bolze A, Itan Y, Goudin N, Cottineau J, Picard C, Abel L, Bustamante J, Casanova J, Puel A
    J Exp Med, 2015-04-27;212(5):619-31.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  186. Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism.
    Authors: Kim J, Tillu D, Quinn T, Mejia G, Shy A, Asiedu M, Murad E, Schumann A, Totsch S, Sorge R, Mantyh P, Dussor G, Price T
    J Neurosci, 2015-04-22;35(16):6307-17.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  187. Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity.
    Authors: Ilkow C, Marguerie M, Batenchuk C, Mayer J, Ben Neriah D, Cousineau S, Falls T, Jennings V, Boileau M, Bellamy D, Bastin D, de Souza C, Alkayyal A, Zhang J, Le Boeuf F, Arulanandam R, Stubbert L, Sampath P, Thorne S, Paramanthan P, Chatterjee A, Strieter R, Burdick M, Addison C, Stojdl D, Atkins H, Auer R, Diallo J, Lichty B, Bell J
    Nat Med, 2015-04-20;21(5):530-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  188. Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5.
    Authors: Simamura E, Arikawa T, Ikeda T, Shimada H, Shoji H, Masuta H, Nakajima Y, Otani H, Yonekura H, Hatta T
    PLoS ONE, 2015-04-10;10(4):e0123232.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  189. Impaired T cell responsiveness to interleukin-6 in hematological patients with invasive aspergillosis.
    Authors: Camargo J, Bhimji A, Kumar D, Kaul R, Pavan R, Schuh A, Seftel M, Lipton J, Gupta V, Humar A, Husain S
    PLoS ONE, 2015-04-02;10(4):e0123171.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  190. Reversible lineage-specific priming of human embryonic stem cells can be exploited to optimize the yield of differentiated cells.
    Authors: Lee J, Graham M, Collins T, Lee J, Hong S, McNicol A, Shapovalova Z, Bhatia M
    Stem Cells, 2015-04-01;33(4):1142-52.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  191. Functional EpoR pathway utilization is not detected in primary tumor cells isolated from human breast, non-small cell lung, colorectal, and ovarian tumor tissues.
    Authors: Patterson, Scott D, Rossi, John M, Paweletz, Katherin, Fitzpatrick, V Dan, Begley, C Glenn, Busse, Leigh, Elliott, Steve, McCaffery, Ian
    PLoS ONE, 2015-03-25;10(3):e0122149.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  192. Molecular mechanisms linking high dose medroxyprogesterone with HIV-1 risk.
    Authors: Irvin S, Herold B
    PLoS ONE, 2015-03-23;10(3):e0121135.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  193. Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFalpha-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction.
    Authors: Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, Usami I, Sakamoto S, Abe H, Watanabe T, Yamori T, Shibasaki M, Nomoto A
    PLoS ONE, 2015-03-18;10(3):e0119415.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  194. Adrenal steroids modulate the immune response during Brucella abortus infection by a mechanism that depends on the regulation of cytokine production.
    Authors: Gentilini M, Velasquez L, Barrionuevo P, Arriola Benitez P, Giambartolomei G, Delpino M
    Infect Immun, 2015-03-02;83(5):1973-82.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  195. Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease
    Authors: James B Canavan
    Gut, 2015-02-24;65(4):584-94.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  196. RelB/p50 complexes regulate cytokine-induced YKL-40 expression.
    Authors: Bhardwaj R, Yester J, Singh S, Biswas D, Surace M, Waters M, Hauser K, Yao Z, Boyce B, Kordula T
    J Immunol, 2015-02-13;194(6):2862-70.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  197. Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M.
    Authors: Kwofie K, Scott M, Rodrigues R, Guerette J, Radford K, Nair P, Richards C
    Respir Res, 2015-02-07;16(0):14.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  198. ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages.
    Authors: Herova M, Schmid M, Gemperle C, Hersberger M
    J Immunol, 2015-01-30;194(5):2330-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  199. Association of antigen-specific T-cell responses with antigen expression and immunoparalysis in multiple myeloma.
    Authors: Fichtner S, Hose D, Engelhardt M, Meissner T, Neuber B, Krasniqi F, Raab M, Schonland S, Ho A, Goldschmidt H, Hundemer M
    Clin Cancer Res, 2015-01-21;21(7):1712-21.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  200. Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells.
    Authors: Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, Hayashi N, Mandai M, Takahashi M
    Invest Ophthalmol Vis Sci, 2015-01-20;56(2):1051-62.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  201. Tricyclic covalent inhibitors selectively target Jak3 through an active site thiol.
    Authors: Goedken E, Argiriadi M, Banach D, Fiamengo B, Foley S, Frank K, George J, Harris C, Hobson A, Ihle D, Marcotte D, Merta P, Michalak M, Murdock S, Tomlinson M, Voss J
    J Biol Chem, 2014-12-31;290(8):4573-89.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  202. P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 (ALK1) inhibits the growth of non small cell lung cancer.
    Authors: Venkatesha V, Joshi A, Venkataraman M, Sonawane V, Bhatia D, Tannu P, Bose J, Choudhari S, Srivastava A, Pandey P, Lad V, Sangana R, Ahmed T, Damre A, Deore V, Sahu B, Kumar S, Sharma S, Agarwal V
    Mol Cancer, 2014-12-02;13(0):259.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  203. Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling.
    Authors: Sobotta M, Liou W, Stocker S, Talwar D, Oehler M, Ruppert T, Scharf A, Dick T
    Nat Chem Biol, 2014-11-24;11(1):64-70.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  204. HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells.
    Authors: Lee D, Sung K, Bartlett D, Kwon Y, Lee Y
    Cell Signal, 2014-11-18;27(2):293-305.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  205. Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy.
    Authors: Lam, Sharon, Sung, Julia, Cruz, Conrad, Castillo-Caro, Paul, Ngo, Minhtran, Garrido, Carolina, Kuruc, Joann, Archin, Nancie, Rooney, Cliona, Margolis, David, Bollard, Catherin
    Mol Ther, 2014-11-04;23(2):387-95.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  206. miR-17-92 cluster promotes cholangiocarcinoma growth: evidence for PTEN as downstream target and IL-6/Stat3 as upstream activator.
    Authors: Zhu H, Han C, Lu D, Wu T
    Am J Pathol, 2014-10-01;184(10):2828-39.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  207. Phosphoinositide protein kinase PDPK1 is a crucial cell signaling mediator in multiple myeloma.
    Authors: Chinen Y, Kuroda J, Shimura Y, Nagoshi H, Kiyota M, Yamamoto-Sugitani M, Mizutani S, Sakamoto N, Ri M, Kawata E, Kobayashi T, Matsumoto Y, Horiike S, Iida S, Taniwaki M
    Cancer Res, 2014-09-30;74(24):7418-29.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  208. Osteoprotegerin, pericytes and bone-like vascular calcification are associated with carotid plaque stability.
    Authors: Davaine J, Quillard T, Brion R, Laperine O, Guyomarch B, Merlini T, Chatelais M, Guilbaud F, Brennan M, Charrier C, Heymann D, Goueffic Y, Heymann M
    PLoS ONE, 2014-09-26;9(9):e107642.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  209. B7-H1-expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets.
    Authors: Kuang D, Xiao X, Zhao Q, Chen M, Li X, Liu R, Wei Y, Ouyang F, Chen D, Wu Y, Lao X, Deng H, Zheng L
    J Clin Invest, 2014-09-17;124(10):4657-67.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  210. Interleukin 7 plays a role in T lymphocyte apoptosis inhibition driven by mesenchymal stem cell without favoring proliferation and cytokines secretion.
    Authors: Normanton M, Alvarenga H, Hamerschlak N, Ribeiro A, Kondo A, Rizzo L, Marti L
    PLoS ONE, 2014-09-03;9(9):e106673.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  211. Direct crosstalk between cancer and osteoblast lineage cells fuels metastatic growth in bone via auto-amplification of IL-6 and RANKL signaling pathways.
    Authors: Zheng Y, Chow S, Boernert K, Basel D, Mikuscheva A, Kim S, Fong-Yee C, Trivedi T, Buttgereit F, Sutherland R, Dunstan C, Zhou H, Seibel M
    J Bone Miner Res, 2014-09-01;29(9):1938-49.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  212. Cross talk with hematopoietic cells regulates the endothelial progenitor cell differentiation of CD34 positive cells.
    Authors: Kwon, Sang-Mo, Lee, Jun-Hee, Lee, Sang-Hun, Jung, Seok-Yun, Kim, Da-Yeon, Kang, Song-Hwa, Yoo, So-Young, Hong, Jong-Kyu, Park, Ji-Hye, Kim, Jung-Hee, Kim, Sung-Woo, Kim, Yeon-Ju, Lee, Sun-Jin, Kim, Hwi-Gon, Asahara, Takayuki
    PLoS ONE, 2014-08-28;9(8):e106310.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  213. Long-term reproducible expression in human fetal liver hematopoietic stem cells with a UCOE-based lentiviral vector.
    Authors: Dighe N, Khoury M, Mattar C, Chong M, Choolani M, Chen J, Antoniou M, Chan J
    PLoS ONE, 2014-08-12;9(8):e104805.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  214. Phosphoproteomic profiling reveals IL6-mediated paracrine signaling within the Ewing sarcoma family of tumors.
    Authors: Anderson J, Titz B, Akiyama R, Komisopoulou E, Park A, Tap W, Graeber T, Denny C
    Mol Cancer Res, 2014-08-04;12(12):1740-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  215. Role of Bruton's tyrosine kinase (BTK) in growth and metastasis of INA6 myeloma cells.
    Authors: Bam R, Venkateshaiah S, Khan S, Ling W, Randal S, Li X, Zhang Q, van Rhee F, Barlogie B, Epstein J, Yaccoby S
    Blood Cancer J, 2014-08-01;4(0):e234.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  216. Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk.
    Authors: Sehgal K, Ragheb R, Fahmy T, Dhodapkar M, Dhodapkar K
    J Immunol, 2014-07-30;193(5):2297-305.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  217. ISL-1 is overexpressed in non-Hodgkin lymphoma and promotes lymphoma cell proliferation by forming a p-STAT3/p-c-Jun/ISL-1 complex.
    Authors: Zhang Q, Yang Z, Jia Z, Liu C, Guo C, Lu H, Chen P, Ma K, Wang W, Zhou C
    Mol Cancer, 2014-07-29;13(0):181.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  218. The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor gammat (RORgammat) in Th17 cells.
    Authors: Han L, Yang J, Wang X, Wu Q, Yin S, Li Z, Zhang J, Xing Y, Chen Z, Tsun A, Li D, Piccioni M, Zhang Y, Guo Q, Jiang L, Bao L, Lv L, Li B
    J Biol Chem, 2014-07-28;289(37):25546-55.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  219. Tumour microenvironment of both early- and late-stage colorectal cancer is equally immunosuppressive.
    Authors: O'Toole A, Michielsen A, Nolan B, Tosetto M, Sheahan K, Mulcahy H, Winter D, Hyland J, O'Connell P, Fennelly D, O'Donoghue D, O'Sullivan J, Doherty G, Ryan E
    Br J Cancer, 2014-07-24;111(5):927-32.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  220. Filarial excretory-secretory products induce human monocytes to produce lymphangiogenic mediators.
    Authors: Weinkopff T, Mackenzie C, Eversole R, Lammie P
    PLoS Negl Trop Dis, 2014-07-10;8(7):e2893.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  221. Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity.
    Authors: Melemedjian O, Tillu D, Moy J, Asiedu M, Mandell E, Ghosh S, Dussor G, Price T
    Mol Pain, 2014-07-04;10(0):45.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  222. Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis.
    Authors: Boettcher S, Gerosa R, Radpour R, Bauer J, Ampenberger F, Heikenwalder M, Kopf M, Manz M
    Blood, 2014-07-02;124(9):1393-403.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  223. PHLDA1 expression is controlled by an estrogen receptor-NFkappaB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres.
    Authors: Kastrati I, Canestrari E, Frasor J
    Oncogene, 2014-06-23;34(18):2309-16.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  224. TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential.
    Authors: Bettini M, Blanchfield L, Castellaw A, Zhang Q, Nakayama M, Smeltzer M, Zhang H, Hogquist K, Evavold B, Vignali D
    J Immunol, 2014-06-18;193(2):571-9.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  225. Biological activities and phytochemical profiles of extracts from different parts of bamboo (Phyllostachys pubescens).
    Authors: Tanaka, Akinobu, Zhu, Qinchang, Tan, Hui, Horiba, Hiroki, Ohnuki, Koichiro, Mori, Yasuhiro, Yamauchi, Ryoko, Ishikawa, Hiroya, Iwamoto, Akira, Kawahara, Hiroharu, Shimizu, Kuniyosh
    Molecules, 2014-06-18;19(6):8238-60.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  226. Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition.
    Authors: Mimura N, Hideshima T, Shimomura T, Suzuki R, Ohguchi H, Rizq O, Kikuchi S, Yoshida Y, Cottini F, Jakubikova J, Cirstea D, Gorgun G, Minami J, Tai Y, Richardson P, Utsugi T, Iwama A, Anderson K
    Cancer Res, 2014-06-16;74(16):4458-69.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  227. Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment.
    Authors: Horwitz, Mitchell, Chao, Nelson J, Rizzieri, David A, Long, Gwynn D, Sullivan, Keith M, Gasparetto, Cristina, Chute, John P, Morris, Ashley, McDonald, Carolyn, Waters-Pick, Barbara, Stiff, Patrick, Wease, Steven, Peled, Amnon, Snyder, David, Cohen, Einat Ga, Shoham, Hadas, Landau, Efrat, Friend, Etty, Peleg, Iddo, Aschengrau, Dorit, Yackoubov, Dima, Kurtzberg, Joanne, Peled, Tony
    J Clin Invest, 2014-06-09;124(7):3121-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  228. The transcriptional responsiveness of LKB1 to STAT-mediated signaling is differentially modulated by prolactin in human breast cancer cells.
    Authors: Linher-Melville, Katja, Singh, Gurmit
    BMC Cancer, 2014-06-09;14(0):415.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  229. Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis.
    Authors: Volpe E, Pattarini L, Martinez-Cingolani C, Meller S, Donnadieu M, Bogiatzi S, Fernandez M, Touzot M, Bichet J, Reyal F, Paronetto M, Chiricozzi A, Chimenti S, Nasorri F, Cavani A, Kislat A, Homey B, Soumelis V
    J Allergy Clin Immunol, 2014-06-06;134(2):373-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  230. Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-alpha, and IL-1beta.
    Authors: Zhao Y, Xiao X, Frank S, Lin H, Xia Y
    Am J Physiol Endocrinol Metab, 2014-06-03;307(2):E186-98.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  231. Identification and characterization of circulating variants of CXCL12 from human plasma: effects on chemotaxis and mobilization of hematopoietic stem and progenitor cells.
    Authors: Richter R, Jochheim-Richter A, Ciuculescu F, Kollar K, Seifried E, Forssmann U, Verzijl D, Smit M, Blanchet X, von Hundelshausen P, Weber C, Forssmann W, Henschler R
    Stem Cells Dev, 2014-05-27;23(16):1959-74.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  232. Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.
    Authors: Kofler D, Marson A, Dominguez-Villar M, Xiao S, Kuchroo V, Hafler D
    J Clin Invest, 2014-05-08;124(6):2513-22.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  233. Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells.
    Authors: Kongsbak M, von Essen M, Boding L, Levring T, Schjerling P, Lauritsen J, Woetmann A, Odum N, Bonefeld C, Geisler C
    PLoS ONE, 2014-05-02;9(5):e96695.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  234. MicroRNA screen of human embryonic stem cell differentiation reveals miR-105 as an enhancer of megakaryopoiesis from adult CD34+ cells.
    Authors: Kamat V, Paluru P, Myint M, French D, Gadue P, Diamond S
    Stem Cells, 2014-05-01;32(5):1337-46.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  235. Protein tyrosine phosphatase PTPN9 regulates erythroid cell development through STAT3 dephosphorylation in zebrafish.
    Authors: Bu Y, Su F, Wang X, Gao H, Lei L, Chang N, Wu Q, Hu K, Zhu X, Chang Z, Meng K, Xiong J
    J Cell Sci, 2014-04-11;127(0):2761-70.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  236. Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling.
    Authors: Shaw S, Bourne T, Meier C, Carrington B, Gelinas R, Henry A, Popplewell A, Adams R, Baker T, Rapecki S, Marshall D, Moore A, Neale H, Lawson A
    MAbs, 2014-04-02;6(3):774-82.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  237. Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene.
    Authors: Al-Sadi R, Ye D, Boivin M, Guo S, Hashimi M, Ereifej L, Ma T
    PLoS ONE, 2014-03-24;9(3):e85345.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  238. Antagonistic determinants controlling replicative and latent states of human cytomegalovirus infection.
    Authors: Umashankar, Mahadeva, Rak, Michael, Bughio, Farah, Zagallo, Patricia, Caviness, Katie, Goodrum, Felicia
    J Virol, 2014-03-12;88(11):5987-6002.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  239. Circumvention of Mcl-1-dependent drug resistance by simultaneous Chk1 and MEK1/2 inhibition in human multiple myeloma cells.
    Authors: Pei X, Dai Y, Felthousen J, Chen S, Takabatake Y, Zhou L, Youssefian L, Sanderson M, Bodie W, Kramer L, Orlowski R, Grant S
    PLoS ONE, 2014-03-04;9(3):e89064.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  240. JAK/STAT3 signaling is required for TGF-beta-induced epithelial-mesenchymal transition in lung cancer cells.
    Authors: Liu R, Zeng Y, Lei Z, Wang L, Yang H, Liu Z, Zhao J, Zhang H
    Int J Oncol, 2014-02-21;44(5):1643-51.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  241. In vitro and in vivo activity of a novel locked nucleic acid (LNA)-inhibitor-miR-221 against multiple myeloma cells.
    Authors: Di Martino M, Gulla A, Gallo Cantafio M, Altomare E, Amodio N, Leone E, Morelli E, Lio S, Caracciolo D, Rossi M, Frandsen N, Tagliaferri P, Tassone P
    PLoS ONE, 2014-02-21;9(2):e89659.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  242. Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-beta (TGF-beta) signaling promoting SMAD3 activation and fibrosis via Gremlin protein.
    Authors: O'Reilly S, Ciechomska M, Cant R, van Laar J
    J Biol Chem, 2014-02-18;289(14):9952-60.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  243. The aryl hydrocarbon receptor is functionally upregulated early in the course ofvhuman T-cell activation.
    Authors: Prigent L, Robineau M, Jouneau S, Morzadec C, Louarn L, Vernhet L, Fardel O, Sparfel L
    Eur J Immunol, 2014-02-18;44(5):1330-40.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  244. cmvIL-10 stimulates the invasive potential of MDA-MB-231 breast cancer cells.
    Authors: Valle Oseguera, Cendy A, Spencer, Juliet V
    PLoS ONE, 2014-02-10;9(2):e88708.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  245. Anti-beta(2)M monoclonal antibodies kill myeloma cells via cell- and complement-mediated cytotoxicity.
    Authors: Zhang M, Qian J, Lan Y, Lu Y, Li H, Hong B, Zheng Y, He J, Yang J, Yi Q
    Int J Cancer, 2014-02-07;135(5):1132-41.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  246. Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators.
    Authors: Milwid, Jack M, Elman, Jessica, Li, Matthew, Shen, Keyue, Manrai, Arjun, Gabow, Aaron, Yarmush, Joshua, Jiao, Yunxin, Fletcher, Anne, Lee, Jungwoo, Cima, Michael, Yarmush, Martin L, Parekkadan, Biju
    Mol Ther, 2014-02-05;22(5):999-1007.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  247. Molecular and stimulus-response profiles illustrate heterogeneity between peripheral and cord blood-derived human mast cells.
    Authors: Jensen B, Frandsen P, Raaby E, Schiotz P, Skov P, Poulsen L
    J Leukoc Biol, 2014-02-03;95(6):893-901.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  248. Mesenchymal stromal cells induce epithelial-to-mesenchymal transition in human colorectal cancer cells through the expression of surface-bound TGF-beta.
    Authors: Mele V, Muraro M, Calabrese D, Pfaff D, Amatruda N, Amicarella F, Kvinlaug B, Bocelli-Tyndall C, Martin I, Resink T, Heberer M, Oertli D, Terracciano L, Spagnoli G, Iezzi G
    Int J Cancer, 2014-01-30;134(11):2583-94.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  249. IL-6 up-regulates the expression of rat LH receptors during granulosa cell differentiation.
    Authors: Imai F, Kishi H, Nakao K, Nishimura T, Minegishi T
    Endocrinology, 2014-01-27;155(4):1436-44.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  250. Digital microfluidic assay for protein detection.
    Authors: Mok J, Mindrinos M, Davis R, Javanmard M
    Proc Natl Acad Sci U S A, 2014-01-21;111(6):2110-5.
    Species: N/A
    Sample Types: Antibody
    Applications: Bioassay, ELISA Standard
  251. Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor.
    Authors: Gupta, Shashi, Hirota, Masao, Waugh, Sheela M, Murakami, Ikuo, Suzuki, Tomoki, Muraguchi, Masahiro, Shibamori, Masafumi, Ishikawa, Yuichi, Jarvis, Thale C, Carter, Jeffrey, Zhang, Chi, Gawande, Bharat, Vrkljan, Michael, Janjic, Nebojsa, Schneider, Daniel J
    J Biol Chem, 2014-01-12;289(12):8706-19.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  252. Multiplexed screening of natural humoral immunity identifies antibodies at fine specificity for complex and dynamic viral targets.
    Authors: McCutcheon, Krista M, Gray, Julia, Chen, Natalie, Liu, Keyi, Park, Minha, Ellsworth, Stote, Tripp, Ralph A, Tompkins, S Mark, Johnson, Scott K, Samet, Shelly, Pereira, Lenore, Kauvar, Lawrence
    MAbs, 2014-01-08;6(2):460-73.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  253. Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes.
    Authors: Suzuki, Hitoshi, Raska, Milan, Yamada, Koshi, Moldoveanu, Zina, Julian, Bruce A, Wyatt, Robert J, Tomino, Yasuhiko, Gharavi, Ali G, Novak, Jan
    J Biol Chem, 2014-01-07;289(8):5330-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  254. Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling.
    Authors: Mleczko-Sanecka K, Roche F, Da Silva A, Call D, D'Alessio F, Ragab A, Lapinski P, Ummanni R, Korf U, Oakes C, Damm G, D'Alessandro L, Klingmuller U, King P, Boutros M, Hentze M, Muckenthaler M
    Blood, 2014-01-02;123(10):1574-85.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  255. Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment.
    Authors: Rodin S, Antonsson L, Niaudet C, Simonson O, Salmela E, Hansson E, Domogatskaya A, Xiao Z, Damdimopoulou P, Sheikhi M, Inzunza J, Nilsson A, Baker D, Kuiper R, Sun Y, Blennow E, Nordenskjold M, Grinnemo K, Kere J, Betsholtz C, Hovatta O, Tryggvason K
    Nat Commun, 2014-01-01;5(0):3195.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  256. Inflammation regulates TMPRSS6 expression via STAT5.
    Authors: Meynard, Delphine, Sun, Chia Chi, Wu, Qifang, Chen, Wenjie, Chen, Shanzhuo, Nelson, Caroline, Waters, Michael, Babitt, Jodie L, Lin, Herbert
    PLoS ONE, 2013-12-23;8(12):e82127.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  257. Establishment of a bortezomib-resistant Chinese human multiple myeloma cell line: MMLAL.
    Authors: Wong, Kwan Yeu, Wan, Thomas S, So, Chi Chiu, Chim, Chor San
    Cancer Cell Int, 2013-12-12;13(1):122.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  258. Tropism of avian influenza A (H5N1) virus to mesenchymal stem cells and CD34+ hematopoietic stem cells.
    Authors: Thanunchai, Maytawan, Kanrai, Pumaree, Wiboon-Ut, Suwimon, Puthavathana, Pilaipan, Hongeng, Suradej, Thitithanyanont, Arunee
    PLoS ONE, 2013-12-10;8(12):e81805.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  259. Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa.
    Authors: Tolar J, McGrath J, Xia L, Riddle M, Lees C, Eide C, Keene D, Liu L, Osborn M, Lund T, Blazar B, Wagner J
    J Invest Dermatol, 2013-12-06;134(5):1246-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  260. beta-Globin sleeping beauty transposon reduces red blood cell sickling in a patient-derived CD34(+)-based in vitro model.
    Authors: Sjeklocha L, Wong P, Belcher J, Vercellotti G, Steer C
    PLoS ONE, 2013-11-18;8(11):e80403.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  261. Blood stem cell fate regulation by Delta-1-mediated rewiring of IL-6 paracrine signaling.
    Authors: Csaszar, Elizabet, Wang, Weijia, Usenko, Tatiana, Qiao, Wenlian, Delaney, Colleen, Bernstein, Irwin D, Zandstra, Peter W
    Blood, 2013-11-15;123(5):650-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  262. Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritis.
    Authors: Dowty, Martin E, Jesson, Michael, Ghosh, Sarbani, Lee, Jamie, Meyer, Debra M, Krishnaswami, Sriram, Kishore, Nandini
    J Pharmacol Exp Ther, 2013-11-11;348(1):165-73.
    Species: Mouse
    Sample Types: Whole Blood
    Applications: Bioassay
  263. NF-kappaB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma.
    Authors: McFarland B, Hong S, Rajbhandari R, Twitty G, Gray G, Yu H, Benveniste E, Nozell S
    PLoS ONE, 2013-11-11;8(11):e78728.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  264. The microvesicle component of HIV-1 inocula modulates dendritic cell infection and maturation and enhances adhesion to and activation of T lymphocytes.
    Authors: Mercier S, Donaghy H, Botting R, Turville S, Harman A, Nasr N, Ji H, Kusebauch U, Mendoza L, Shteynberg D, Sandgren K, Simpson R, Moritz R, Cunningham A
    PLoS Pathog, 2013-10-17;9(10):e1003700.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  265. Reference range and short- and long-term biological variation of interleukin (IL)-6, IL-17A and tissue necrosis factor-alpha using high sensitivity assays.
    Authors: Todd J, Simpson P, Estis J, Torres V, Wub A
    Cytokine, 2013-10-12;64(3):660-5.
    Species: Human
    Sample Types: Plasma
    Applications: ELISA (Standard)
  266. Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors.
    Authors: Doulatov S, Vo L, Chou S, Kim P, Arora N, Li H, Hadland B, Bernstein I, Collins J, Zon L, Daley G
    Cell Stem Cell, 2013-10-03;13(4):459-70.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  267. EGFR inhibition induces proinflammatory cytokines via NOX4 in HNSCC.
    Authors: Fletcher E, Love-Homan L, Sobhakumari A, Feddersen C, Koch A, Goel A, Simons A
    Mol Cancer Res, 2013-09-18;11(12):1574-84.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  268. Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma.
    Authors: Zheng Y, McFarland B, Drygin D, Yu H, Bellis S, Kim H, Bredel M, Benveniste E
    Clin Cancer Res, 2013-09-13;19(23):6484-94.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  269. Histone deacetylase 3 as a novel therapeutic target in multiple myeloma.
    Authors: Minami J, Suzuki R, Mazitschek R, Gorgun G, Ghosh B, Cirstea D, Hu Y, Mimura N, Ohguchi H, Cottini F, Jakubikova J, Munshi N, Haggarty S, Richardson P, Hideshima T, Anderson K
    Leukemia, 2013-08-05;28(3):680-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  270. CTR9, a component of PAF complex, controls elongation block at the c-Fos locus via signal-dependent regulation of chromatin-bound NELF dissociation.
    Authors: Yoo H, Seo J, Yoo J
    PLoS ONE, 2013-04-11;8(4):e61055.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  271. p53 controls autoimmune arthritis via STAT-mediated regulation of the Th17 cell/Treg cell balance in mice.
    Authors: Park J, Lim M, Cho M, Ryu J, Moon Y, Jhun J, Byun J, Kim E, Hwang S, Ju J, Kwok S, Kim H
    Arthritis Rheum, 2013-04-01;65(4):949-59.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  272. BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state.
    Authors: Melemedjian O, Tillu D, Asiedu M, Mandell E, Moy J, Blute V, Taylor C, Ghosh S, Price T
    Mol Pain, 2013-03-20;9(0):12.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  273. IL-6-174 G > C and MMP-9-1562 C > T polymorphisms are associated with increased risk of deep vein thrombosis in cancer patients.
    Authors: Malaponte G, Polesel J, Candido S, Sambataro D, Bevelacqua V, Anzaldi M, Vella N, Fiore V, Militello L, Mazzarino M, Libra M, Signorelli S
    Cytokine, 2013-03-11;62(1):64-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  274. Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets.
    Authors: El-Zaatari M, Kao J, Tessier A, Bai L, Hayes M, Fontaine C, Eaton K, Merchant J
    PLoS ONE, 2013-03-08;8(3):e58935.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  275. Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth.
    Authors: Leone E, Morelli E, Di Martino M, Amodio N, Foresta U, Gulla A, Rossi M, Neri A, Giordano A, Munshi N, Anderson K, Tagliaferri P, Tassone P
    Clin Cancer Res, 2013-02-27;19(8):2096-106.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  276. Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients.
    Authors: Srivastava R, Lee S, Andrade Filho P, Lord C, Jie H, Davidson H, Lopez-Albaitero A, Gibson S, Gooding W, Ferrone S, Ferris R
    Clin Cancer Res, 2013-02-26;19(7):1858-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  277. Protein carbamylation predicts mortality in ESRD.
    Authors: Koeth R, Kalantar-Zadeh K, Wang Z, Fu X, Tang W, Hazen S
    2013-02-21;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: ELISA (Standard)
  278. Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target.
    Authors: Verjee L, Verhoekx J, Chan J, Krausgruber T, Nicolaidou V, Izadi D, Davidson D, Feldmann M, Midwood K, Nanchahal J
    Proc Natl Acad Sci U S A, 2013-02-19;110(10):E928-37.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  279. Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia.
    Authors: Yu, Jianhua, Peng, Yong, Wu, Lai-Chu, Xie, Zhiliang, Deng, Youcai, Hughes, Tiffany, He, Shun, Mo, XiaoKui, Chiu, Ming, Wang, Qi-En, He, Xiaoming, Liu, Shujun, Grever, Michael, Chan, Kenneth, Liu, Zhongfa
    PLoS ONE, 2013-02-13;8(2):e55934.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  280. Allelic exclusion and peripheral reconstitution by TCR transgenic T cells arising from transduced human hematopoietic stem/progenitor cells.
    Authors: Giannoni F, Hardee C, Wherley J, Gschweng E, Senadheera S, Kaufman M, Chan R, Bahner I, Gersuk V, Wang X, Gjertson D, Baltimore D, Witte O, Economou J, Ribas A, Kohn D
    Mol Ther, 2013-02-05;21(5):1044-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  281. Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis.
    Authors: Johnston A, Xing X, Swindell W, Kochkodan J, Riblett M, Nair R, Stuart P, Ding J, Voorhees J, Elder J, Gudjonsson J
    Hum Mol Genet, 2013-01-31;22(9):1807-15.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  282. Regulation of the formyl peptide receptor 1 (FPR1) gene in primary human macrophages.
    Authors: Gemperle C, Schmid M, Herova M, Marti-Jaun J, Wuest S, Loretz C, Hersberger M
    PLoS ONE, 2012-11-21;7(11):e50195.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  283. Mycobacterium tuberculosis infection and tissue factor expression in macrophages.
    Authors: Kothari H, Rao L, Vankayalapati R, Pendurthi U
    PLoS ONE, 2012-09-24;7(9):e45700.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  284. The reactivity, distribution and abundance of Non-astrocytic Inner Retinal Glial (NIRG) cells are regulated by microglia, acute damage, and IGF1.
    Authors: Zelinka C, Scott M, Volkov L, Fischer A
    PLoS ONE, 2012-09-04;7(9):e44477.
    Species: Chicken
    Sample Types: In Vivo
    Applications: In Vivo
  285. CD4 T follicular helper cell dynamics during SIV infection.
    J. Clin. Invest., 2012-08-27;122(9):3281-94.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  286. The C-type Lectin Receptor CLECSF8 (CLEC4D) Is Expressed by Myeloid Cells and Triggers Cellular Activation through Syk Kinase.
    Authors: Graham LM, Gupta V, Schafer G, Reid DM, Kimberg M, Dennehy KM, Hornsell WG, Guler R, Campanero-Rhodes MA, Palma AS, Feizi T, Kim SK, Sobieszczuk P, Willment JA, Brown GD
    J. Biol. Chem., 2012-06-11;287(31):25964-74.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  287. Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta.
    Authors: Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A, Sallusto F
    Nature, 2012-04-26;484(7395):514-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  288. Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation.
    Authors: Napoletano C, Zizzari IG, Rughetti A, Rahimi H, Irimura T, Clausen H, Wandall HH, Belleudi F, Bellati F, Pierelli L, Frati L, Nuti M
    Eur. J. Immunol., 2012-04-01;42(4):936-45.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  289. Generation of allo-restricted peptide-specific T cells using RNA-pulsed dendritic cells: A three phase experimental procedure.
    Authors: Wilde S, Geiger C, Milosevic S, Mosetter B, Eichenlaub S, Schendel D
    Oncoimmunology, 2012-03-01;1(2):129-140.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  290. Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis.
    Authors: Hong YS, Moon SJ, Moon S, Joo YB, Joo Y, Jeon CH, Jeon C, Cho ML, Ju JH, Oh HJ, Heo YJ, Heo Y, Park SH, Kim HY, Min JK
    J Korean Med Sci, 2011-09-01;26(9):1132-9.
    Applications: ELISA (Standard)
  291. Identification of IDO-positive and IDO-negative human dendritic cells after activation by various proinflammatory stimuli.
    Authors: Von Bubnoff D, Scheler M, Wilms H, Fimmers R, Bieber T
    J. Immunol., 2011-05-04;186(12):6701-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  292. Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages.
    Authors: Liao W, Lin JX, Wang L, Li P, Leonard WJ
    Nat. Immunol., 2011-04-24;12(6):551-9.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  293. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation.
    Authors: Steinbicker AU, Sachidanandan C, Vonner AJ
    Blood, 2011-03-10;117(18):4915-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  294. Increased numbers of immature plasma cells in peripheral blood specifically overexpress chemokine receptor CXCR3 and CXCR4 in patients with ulcerative colitis.
    Authors: Hosomi S, Oshitani N, Kamata N, Sogawa M, Okazaki H, Tanigawa T, Yamagami H, Watanabe K, Tominaga K, Watanabe T, Fujiwara Y, Maeda K, Hirakawa K, Arakawa T
    Clin. Exp. Immunol., 2010-11-19;163(2):215-24.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  295. Increased B7-H1 expression on dendritic cells correlates with programmed death 1 expression on T cells in simian immunodeficiency virus-infected macaques and may contribute to T cell dysfunction and disease progression.
    Authors: Xu H, Wang X, Pahar B
    J. Immunol., 2010-11-08;185(12):7340-8.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  296. Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome).
    Authors: Tolar J, Park I, Xia L, Lees C, Peacock B, Webber B, McElmurry R, Eide C, Orchard P, Kyba M, Osborn M, Lund T, Wagner J, Daley G, Blazar B
    Blood, 2010-10-29;117(3):839-47.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  297. Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation.
    Authors: Jones GW, Stumhofer JS, Foster T, Twohig JP, Hertzog P, Topley N, Williams AS, Hunter CA, Jenkins BJ, Wang EC, Jones SA
    FASEB J., 2010-09-08;25(1):409-19.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  298. Wnt3a activates dormant c-Kit(-) bone marrow-derived cells with short-term multilineage hematopoietic reconstitution capacity.
    Authors: Trowbridge JJ, Guezguez B, Moon RT
    Stem Cells, 2010-08-01;28(8):1379-89.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  299. Distinct roles of hepatocyte- and myeloid cell-derived IL-1 receptor antagonist during endotoxemia and sterile inflammation in mice.
    Authors: Lamacchia C, Palmer G, Bischoff L, Rodriguez E, Talabot-Ayer D, Gabay C
    J. Immunol., 2010-07-16;185(0):2516-24.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  300. Oligo-guanosine nucleotide induces neuropilin-1 internalization in endothelial cells and inhibits angiogenesis.
    Authors: Narazaki M, Segarra M, Hou X, Tanaka T, Li X, Tosato G
    Blood, 2010-07-06;116(16):3099-107.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  301. Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid.
    Authors: Morizane S, Yamasaki K, Kabigting FD, Gallo RL
    J. Invest. Dermatol., 2010-01-21;130(5):1297-306.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  302. Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease.
    Authors: Liu X, Leung S, Wang C, Tan Z, Wang J, Guo TB, Fang L, Zhao Y, Wan B, Qin X, Lu L, Li R, Pan H, Song M, Liu A, Hong J, Lu H, Zhang JZ
    Nat. Med., 2010-01-10;16(2):191-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  303. Regulating human Th17 cells via differential expression of IL-1 receptor.
    Authors: Lee WW, Kang SW, Choi J
    Blood, 2009-11-12;115(3):530-40.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  304. IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients.
    Authors: Heo YJ, Joo YB, Oh HJ, Park MK, Heo YM, Cho ML, Kwok SK, Ju JH, Park KS, Cho SG, Park SH, Kim HY, Min JK
    Immunol. Lett., 2009-11-04;127(2):150-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  305. Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation.
    Authors: Funderburg NT, Mayne E, Sieg SF
    Blood, 2009-10-14;115(2):161-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  306. Mast cell-dependent contraction of human airway smooth muscle cell-containing collagen gels: influence of cytokines, matrix metalloproteases, and serine proteases.
    Authors: Margulis A, Nocka KH, Brennan AM, Deng B, Fleming M, Goldman SJ, Kasaian MT
    J. Immunol., 2009-07-10;183(3):1739-50.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  307. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.
    Authors: Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F
    Nat. Immunol., 2009-07-05;10(8):857-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  308. Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases.
    Authors: Ye L, Chang JC, Lin C, Sun X, Yu J, Kan YW
    Proc. Natl. Acad. Sci. U.S.A., 2009-05-29;106(24):9826-30.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  309. TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23.
    Authors: Aliahmadi E, Gramlich R, Grutzkau A, Hitzler M, Kruger M, Baumgrass R, Schreiner M, Wittig B, Wanner R, Peiser M
    Eur. J. Immunol., 2009-05-01;39(5):1221-30.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  310. Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.
    Authors: Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R
    J. Exp. Med., 2009-03-09;206(3):535-48.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  311. Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts.
    Authors: Amiable N, Tat SK, Lajeunesse D, Duval N, Pelletier JP, Martel-Pelletier J, Boileau C
    Bone, 2009-03-02;44(6):1143-50.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  312. Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells.
    Authors: Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G
    Circulation, 2009-03-02;119(10):1424-32.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  313. Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes.
    Authors: Yammani RR, Long D, Loeser RF
    Arthritis Rheum., 2009-03-01;60(3):792-800.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  314. Prostate cancer promotes CD11b positive cells to differentiate into osteoclasts.
    Authors: Mizutani K, Sud S, Pienta KJ
    J. Cell. Biochem., 2009-03-01;106(4):563-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  315. Hyperbaric oxygen causes both antiinflammation and antipyresis in rabbits.
    Authors: Niu KC, Huang WT, Lin MT, Huang KF
    Eur. J. Pharmacol., 2009-01-21;606(1):240-5.
    Species: Rabbit
    Sample Types: In Vivo
    Applications: In Vivo
  316. Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells.
    Authors: Ara T, Song L, Shimada H, Keshelava N, Russell HV, Metelitsa LS, Groshen SG, Seeger RC, DeClerck YA
    Cancer Res., 2009-01-01;69(1):329-37.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  317. IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response.
    Authors: Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A
    J. Allergy Clin. Immunol., 2008-12-03;123(1):59-66.e4.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  318. Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts.
    Authors: Kwan Tat S, Pelletier JP, Amiable N, Boileau C, Lajeunesse D, Duval N, Martel-Pelletier J
    Arthritis Rheum., 2008-12-01;58(12):3820-30.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  319. Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production.
    Authors: Ahmed S, Marotte H, Kwan K, Ruth JH, Campbell PL, Rabquer BJ, Pakozdi A, Koch AE
    Proc. Natl. Acad. Sci. U.S.A., 2008-09-16;105(38):14692-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  320. IL-6 cytoprotection in hyperoxic acute lung injury occurs via suppressor of cytokine signaling-1-induced apoptosis signal-regulating kinase-1 degradation.
    Authors: Kolliputi N, Waxman AB
    Am. J. Respir. Cell Mol. Biol., 2008-09-05;40(3):314-24.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  321. Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6.
    Authors: Hollins F, Kaur D, Yang W, Cruse G, Saunders R, Sutcliffe A, Berger P, Ito A, Brightling CE, Bradding P
    J. Immunol., 2008-08-15;181(4):2772-80.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  322. Maternal and cord plasma cytokine and chemokine profile in pregnancies complicated by asthma.
    Authors: Osei-Kumah A, Smith R, Clifton VL
    Cytokine, 2008-07-17;43(2):187-93.
    Applications: ELISA (Standard)
  323. IFN-alpha induces transcription of hypoxia-inducible factor-1alpha to inhibit proliferation of human endothelial cells.
    Authors: Gerber SA, Pober JS
    J. Immunol., 2008-07-15;181(2):1052-62.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  324. IL-12-impaired and IL-12-secreting dendritic cells produce IL-23 upon CD154 restimulation.
    Authors: Jasny E, Eisenblatter M, Matz-Rensing K, Tenner-Racz K, Tenbusch M, Schrod A, Stahl-Hennig C, Moos V, Schneider T, Racz P, Uberla K, Kaup FJ, Ignatius R
    J. Immunol., 2008-05-15;180(10):6629-39.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  325. Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps.
    Authors: Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R, Conley D, Grammer LC, Kern R, Schleimer RP
    J. Allergy Clin. Immunol., 2008-04-14;121(6):1385-92, 1392.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  326. Interleukin-6 as a photoreceptor neuroprotectant in an experimental model of retinal detachment.
    Authors: Chong DY, Boehlke CS, Zheng QD, Zhang L, Han Y, Zacks DN
    Invest. Ophthalmol. Vis. Sci., 2008-03-31;49(7):3193-200.
    Species: Mouse, Rat
    Sample Types: In Vivo
    Applications: In Vivo
  327. Refreezing of cord blood hematopoietic stem cells for allogenic transplantation: in vitro and in vivo validation of a clinical phase I/II protocol in European and Italian Good Manufacturing Practice conditions.
    Authors: Gunetti M, Ferrero I, Rustichelli D, Berger M, Gammaitoni L, Timeus F, Piacibello W, Aglietta M, Fagioli F
    Exp. Hematol., 2008-02-01;36(2):235-43.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  328. IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells.
    Authors: Yang HT, Cohen P, Rousseau S
    Cell. Signal., 2007-11-07;20(2):375-80.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  329. Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling.
    Authors: Liotta F, Angeli R, Cosmi L, Fili L, Manuelli C, Frosali F, Mazzinghi B, Maggi L, Pasini A, Lisi V, Santarlasci V, Consoloni L, Angelotti ML, Romagnani P, Parronchi P, Krampera M, Maggi E, Romagnani S, Annunziato F
    Stem Cells, 2007-10-25;26(1):279-89.
    Applications: ELISA (Standard)
  330. Neutralizing B-cell activating factor antibody improves survival and inhibits osteoclastogenesis in a severe combined immunodeficient human multiple myeloma model.
    Authors: Neri P, Kumar S, Fulciniti MT, Vallet S, Chhetri S, Mukherjee S, Tai Y, Chauhan D, Tassone P, Venuta S, Munshi NC, Hideshima T, Anderson KC, Raje N
    Clin. Cancer Res., 2007-10-01;13(19):5903-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  331. Ultrasensitive flow-based immunoassays using single-molecule counting.
    Authors: Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P
    Clin. Chem., 2007-09-21;53(11):1990-5.
    Applications: ELISA (Standard)
  332. Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration.
    Authors: Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, Mo W, Wen D, Miatkowski K, Gonzales M, Sanicola M, Seno M, Salomon DS
    J. Biol. Chem., 2007-08-24;282(43):31643-55.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  333. Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques.
    Authors: Zahorchak AF, Kean LS, Tokita D, Turnquist HR, Abe M, Finke J, Hamby K, Rigby MR, Larsen CP, Thomson AW
    Transplantation, 2007-07-27;84(2):196-206.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  334. Antiparallel segregation of notch components in the immunological synapse directs reciprocal signaling in allogeneic Th:DC conjugates.
    Authors: Luty WH, Rodeberg D, Parness J, Vyas YM
    J. Immunol., 2007-07-15;179(2):819-29.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  335. Synergism of TNF and IL-1 in the induction of matrix metalloproteinase-3 in trabecular meshwork.
    Authors: Kelley MJ, Rose AY, Song K, Chen Y, Bradley JM, Rookhuizen D, Acott TS
    Invest. Ophthalmol. Vis. Sci., 2007-06-01;48(6):2634-43.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  336. IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease.
    Authors: Wolk K, Witte E, Hoffmann U, Doecke WD, Endesfelder S, Asadullah K, Sterry W, Volk HD, Wittig BM, Sabat R
    J. Immunol., 2007-05-01;178(9):5973-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  337. Beta-2-microglobulin is an androgen-regulated secreted protein elevated in serum of patients with advanced prostate cancer.
    Authors: Gross M, Top I, Laux I, Katz J, Curran J, Tindell C, Agus D
    Clin. Cancer Res., 2007-04-01;13(7):1979-86.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  338. Leukemia inhibitory factor functions as a growth factor in pancreas carcinoma cells: Involvement of regulation of LIF and its receptor expression.
    Authors: Kamohara H, Ogawa M, Ishiko T, Sakamoto K, Baba H
    Int. J. Oncol., 2007-04-01;30(4):977-83.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  339. Inflammatory cytokines stimulate the adhesion of colon carcinoma cells to mesothelial monolayers.
    Authors: van Grevenstein WM, Hofland LJ, van Rossen ME, van Koetsveld PM, Jeekel J, van Eijck CH
    Dig. Dis. Sci., 2007-03-30;52(10):2775-83.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  340. IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells.
    Authors: Ettinger R, Sims GP, Robbins R, Withers D, Fischer RT, Grammer AC, Kuchen S, Lipsky PE
    J. Immunol., 2007-03-01;178(5):2872-82.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  341. Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression.
    Authors: Brechter AB, Lerner UH
    Arthritis Rheum., 2007-03-01;56(3):910-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  342. Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells.
    Authors: Rajesh</LastName><ForeNam D</Initial, Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF
    Stem Cells, 2007-02-01;25(2):490-9.
    Species: Human, Mouse, Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  343. Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators.
    Authors: Orfanos SE, Kotanidou A, Glynos C, Athanasiou C, Tsigkos S, Dimopoulou I, Sotiropoulou C, Zakynthinos S, Armaganidis A, Papapetropoulos A, Roussos C
    Crit. Care Med., 2007-01-01;35(1):199-206.
    Species: Bovine, Human
    Sample Types: Whole Cells
    Applications: Bioassay
  344. Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes.
    Authors: Sugaya M, Fang L, Cardones AR, Kakinuma T, Jaber SH, Blauvelt A, Hwang ST
    J. Immunol., 2006-12-01;177(11):7665-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  345. An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium.
    Authors: Johnson LA, Clasper S, Holt AP, Lalor PF, Baban D, Jackson DG
    J. Exp. Med., 2006-11-20;203(12):2763-77.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  346. Development of an in vitro pancreatic tissue model to study regulation of islet neogenesis associated protein expression.
    Authors: Petropavlovskaia M, Makhlin J, Sampalis J, Rosenberg L
    J. Endocrinol., 2006-10-01;191(1):65-81.
    Species: Hamster
    Sample Types: Whole Cells
    Applications: Bioassay
  347. Effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle.
    Authors: Ammit AJ, Moir LM, Oliver BG, Hughes JM, Alkhouri H, Ge Q, Burgess JK, Black JL, Roth M
    Am. J. Physiol. Lung Cell Mol. Physiol., 2006-08-25;292(1):L199-206.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  348. Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cells.
    Authors: Gemelli C, Montanari M, Tenedini E, Zanocco Marani T, Vignudelli T, Siena M, Zini R, Salati S, Tagliafico E, Manfredini R, Grande A, Ferrari S
    Cell Death Differ., 2006-02-03;13(10):1686-96.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  349. Th2 cytokine response in Major Depressive Disorder patients before treatment.
    Authors: Kiryushko D, Pavon L, Novitskaya V, Sandoval-Lopez G, Soroka V, Eugenia Hernandez M, Klingelhofer J, Loria F, Lukanidin E, Estrada I, Berezin V, Perez M, Bock E, Moreno J, Avila U, Leff P, Anton B, Heinze G
    J. Neuroimmunol., 2006-02-02;172(1):156-65.
    Applications: ELISA (Standard)
  350. Phenotype and function of myeloid dendritic cells derived from African green monkey blood monocytes.
    Authors: Mortara L, Ploquin MJ, Faye A, Scott-Algara D, Vaslin B, Butor C, Hosmalin A, Barre-Sinoussi F, Diop OM, Muller-Trutwin MC
    J. Immunol. Methods, 2005-11-21;308(1):138-55.
    Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
    Sample Types: Whole Cells
    Applications: Bioassay
  351. A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo.
    Authors: von Strandmann EP, Hansen HP, Reiners KS, Schnell R, Borchmann P, Merkert S, Simhadri VR, Draube A, Reiser M, Purr I, Hallek M, Engert A
    Blood, 2005-10-06;107(5):1955-62.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  352. Human airway epithelial cell determinants of survival and functional phenotype for primary human mast cells.
    Authors: Hsieh FH, Sharma P, Gibbons A, Goggans T, Erzurum SC, Haque SJ
    Proc. Natl. Acad. Sci. U.S.A., 2005-09-26;102(40):14380-5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  353. Growth hormone-induced stimulation of multilineage human hematopoiesis.
    Authors: Hanley MB, Napolitano LA, McCune JM
    Stem Cells, 2005-06-13;23(8):1170-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  354. Interleukin-6 and interleukin-8 in cervical fluid in a population of Swedish women in preterm labor: relationship to microbial invasion of the amniotic fluid, intra-amniotic inflammation, and preterm delivery.
    Authors: Holst RM, Mattsby-Baltzer I, Wennerholm UB, Hagberg H, Jacobsson B
    Acta Obstet Gynecol Scand, 2005-06-01;84(6):551-7.
    Applications: ELISA (Standard)
  355. Interface tissue fibroblasts from loose total hip replacement prosthesis produce receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and cathepsin K.
    Authors: Mandelin J, Li TF, Hukkanen M, Liljestrom M, Salo J, Santavirta S, Konttinen YT
    J. Rheumatol., 2005-04-01;32(4):713-20.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  356. Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta.
    Authors: Nagineni CN, Kutty V, Detrick B, Hooks JJ
    J. Cell. Physiol., 2005-04-01;203(1):35-43.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  357. trans fatty acids and systemic inflammation in heart failure.
    Authors: Mozaffarian D, Rimm EB, King IB, Lawler RL, McDonald GB, Levy WC
    Am. J. Clin. Nutr., 2004-12-01;80(6):1521-5.
    Applications: ELISA (Standard)
  358. Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs.
    Authors: Ferlazzo G, Pack M, Thomas D, Paludan C, Schmid D, Strowig T, Bougras G, Muller WA, Moretta L, Munz C
    Proc. Natl. Acad. Sci. U.S.A., 2004-11-09;101(47):16606-11.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  359. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways.
    Authors: Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R
    J. Immunol., 2004-09-01;173(5):3482-91.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  360. IL-22 increases the innate immunity of tissues.
    Authors: Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R
    Immunity, 2004-08-01;21(2):241-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  361. Lack of phenotypic and functional impairment in dendritic cells from chimpanzees chronically infected with hepatitis C virus.
    Authors: Larsson M, Babcock E, Grakoui A, Shoukry N, Lauer G, Rice C, Walker C, Bhardwaj N
    J. Virol., 2004-06-01;78(12):6151-61.
    Species: Primate - Pan troglodytes (Chimpanzee)
    Sample Types: Whole Cells
    Applications: Bioassay
  362. Rapid analysis of inflammatory cytokines in cerebrospinal fluid using chip-based immunoaffinity electrophoresis.
    Authors: Phillips TM
    Electrophoresis, 2004-06-01;25(10):1652-9.
  363. CD14 is an acute-phase protein.
    Authors: Bas S, Gauthier BR, Spenato U, Stingelin S, Gabay C
    J. Immunol., 2004-04-01;172(7):4470-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  364. Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines.
    Authors: Copeland S, Siddiqui J, Remick D
    J. Immunol. Methods, 2004-01-01;284(1):99-106.
    Applications: ELISA (Standard)
  365. Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation.
    Authors: McLoughlin RM, Witowski J, Robson RL, Wilkinson TS, Hurst SM, Williams AS, Williams JD, Rose-John S, Jones SA, Topley N
    J. Clin. Invest., 2003-08-01;112(4):598-607.
    Applications: ELISA (Standard)
  366. Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells.
    Authors: Hurst SM, McLoughlin RM, Monslow J, Owens S, Morgan L, Fuller GM, Topley N, Jones SA
    J. Immunol., 2002-11-01;169(9):5244-51.
    Applications: ELISA (Standard)
  367. Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells.
    Authors: Erices A, Conget P, Rojas C, Minguell JJ
    Exp. Cell Res., 2002-10-15;280(1):24-32.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  368. Expression of interleukin (IL)-11 receptor by the human endometrium in vivo and effects of IL-11, IL-6 and LIF on the production of MMP and cytokines by human endometrial cells in vitro.
    Authors: Cork BA, 146, Tuckerman EM, Li TC, Laird SM
    2002-09-01;8(9):841-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  369. Prospective isolation of human clonogenic common myeloid progenitors.
    Authors: Manz MG, 107325, Miyamoto T, Akashi K, Weissman IL
    Ultra-Sensitive and Semi-Quantitative Vertical Flow Assay for the Rapid Detection of Interleukin-6 in Inflammatory Diseases, 2002-08-22;99(18):11872-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  370. A secreted and LIF-mediated stromal cell-derived activity that promotes ex vivo expansion of human hematopoietic stem cells.
    Authors: Shih CC, Hu MC, Hu J
    Blood, 2000-03-15;95(6):1957-66.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  371. Genetically modified CD34+ cells as cellular vehicles for gene delivery into areas of angiogenesis in a rhesus model.
    Authors: Gomez-Navarro J, ¯&h~²@á, Contreras JL, Arafat W, Jiang XL, Krisky D, Oligino T, Marconi P, Hubbard B, Glorioso JC, Curiel DT, Thomas JM
    2000-01-01;7(1):43-52.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  372. Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I.
    Authors: Akagi Y, Liu W, Zebrowski B, Xie K, Ellis LM
    Cancer Res., 1998-09-01;58(17):4008-14.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  373. Expression of Fas/CD95 and Bcl-2 by primitive hematopoietic progenitors freshly isolated from human fetal liver.
    Authors: Barcena A, Park SW, Banapour B, Muench MO, Mechetner E
    Blood, 1996-09-15;88(6):2013-25.
    Species: Human
    Sample Types:
    Applications: Bioassay

FAQs

  1. Can Recombinant Human IL-6 protein (Catalog # 206-IL) be used on mouse cells?

    • We evaluate the bioactivity of Recombinant Human IL-6 Protein (Catalog # 206-IL) in a cell proliferation assay using mouse plasmacytoma cells during QC testing. Catalog # 206-IL exhibits an ED50 in the range of 0.2-0.8 ng/mL in this assay using mouse cells. We have evaluated the human and mouse IL-6 proteins in the same assay and found the Recombinant Mouse IL-6 Protein (Catalog # 406-ML) was more active with mouse cells. This information can be found in the activity section on the respective product datasheets. 

  2. What are the differences between Recombinant Human IL-6 Protein (Catalog # 206-IL) and Recombinant Human IL-6 (HEK293-expressed) Protein (Catalog # 7270-IL)?

    • Recombinant Human IL-6 Protein (Catalog # 206-IL) is raised in E. coli. The Recombinant Human IL-6 (HEK293-expressed) Protein (Catalog # 7270-IL) is raised in HEK293. Because #7270-IL is raised in mammalian cells, it is expected to have post translational modifications that are absent in the E. coli-derived version (206-IL). The HEK293-derived #7270-IL exhibits greater activity than the E. coli-derived #206-IL in the same activity assay.

View all Proteins and Enzyme FAQs
Loading...

Reviews for Recombinant Human IL-6 Protein

Average Rating: 4.7 (Based on 26 Reviews)

5 Star
73.08%
4 Star
23.08%
3 Star
3.85%
2 Star
0%
1 Star
0%

Have you used Recombinant Human IL-6 Protein?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Recombinant Human IL-6 Protein
By Lana Jagannathan on 08/26/2024
Application: Stem/Immune cell maintenance or differentiation
Reason for Rating: We have been purchasing this cytokine for over a year and it has been extremely effective at producing a dendritic cell maturation response when combined with other cytokines.
Stem/Immune cell maintenance or differentiation Recombinant Human IL-6 Protein 206-IL
Recombinant Human IL-6 Protein
By Anonymous on 11/15/2023
Application: Stem/Immune cell maintenance or differentiation
Stem/Immune cell maintenance or differentiation Recombinant Human IL-6 Protein 206-IL
Recombinant Human IL-6 Protein
By Anonymous on 07/25/2023
Application: Cell migration/motility
Cell migration/motility Recombinant Human IL-6 Protein 206-IL
Recombinant Human IL-6 Protein
By Anonymous on 01/17/2022
Application: CellProlif
Cell Proliferation Recombinant Human IL-6 Protein 206-IL
Recombinant Human IL-6 Protein
By Anonymous on 08/07/2021
Application: In vitro bioactivity in cell culture
Recombinant Human IL-6 Protein
By Anonymous on 05/24/2021
Application: CellProlif
Recombinant Human IL-6 Protein
By Anonymous on 03/06/2021
Application: In vitro bioactivity in cell culture
Recombinant Human IL-6 Protein
By Anonymous on 02/09/2021
Application: Assay validation
Recombinant Human IL-6 Protein
By tehyeon kim on 01/17/2020
Application: CellProlif
Recombinant Human IL-6 Protein
By Anonymous on 01/10/2020
Application: In vitro bioactivity in cell culture
Recombinant Human IL-6 Protein
By Anonymous on 02/25/2019
Application: CellProlif
Recombinant Human IL-6 Protein
By Zoia Levashova on 11/26/2018
Application: MSD assay

The recombinant human IL-6 protein was used as the calibration reagent in MSD assay with biotinylated MAB206 (capture) and Sulfo-Tag labeled AF-206-NA (detection) antibodies.

Other Recombinant Human IL-6 Protein 206-IL
Recombinant Human IL-6 Protein
By Anonymous on 10/08/2018
Application: In vitro bioactivity in cell culture
Recombinant Human IL-6 Protein
By Anonymous on 05/11/2018
Application: CellProlif
Recombinant Human IL-6 Protein
By Anonymous on 03/02/2018
Application: CellProlif
Cell Proliferation Recombinant Human IL-6 Protein 206-IL
Recombinant Human IL-6 Protein
By Anonymous on 02/11/2018
Application: In vitro bioactivity in cell culture
Recombinant Human IL-6 Protein
By Anonymous on 06/28/2017
Application: In vitro bioactivity in cell culture
Recombinant Human IL-6 Protein
By Boubacar Barry on 06/01/2017
Application: In vitro bioactivity in cell culture
Recombinant Human IL-6 Protein
By Anonymous on 05/23/2017
Application: Cell migration/motility
Recombinant Human IL-6 Protein
By Michelle Chen on 04/26/2017
Application: In vitro bioactivity in cell culture
Recombinant Human IL-6 Protein
By Anonymous on 12/15/2016
Application: Stem/Immune cell maintenance or differentiation

Elevated levels of the proinflammatory cytokine IL-6 are associated with poor survival outcomes in many cancers. Antibodies targeting IL-6 and its receptor have been developed for chronic inflammatory disease, but they have not yet been shown to clearly benefit cancer patients, possibly due to antibody potency or the settings in which they have been tested. In this study, we describe the development of a novel high-affinity anti-IL-6 antibody, MEDI5117, which features an extended half-life and potent inhibitory effects on IL-6 biologic activity. MEDI5117 inhibited IL-6-mediated activation of STAT3, suppressing the growth of several tumor types driven by IL-6 autocrine signaling. In the same models, MEDI5117 displayed superior preclinical activity relative to a previously developed anti-IL-6 antibody. Consistent with roles for IL-6 in promoting tumor angiogenesis, we found that MEDI5117 inhibited the growth of endothelial cells, which can produce IL-6 and support tumorigenesis. Notably, in tumor xenograft assays.

Recombinant Human IL-6 Protein
By Veronica Fregoso on 08/01/2016
Application: In vitro bioactivity in cell culture

Primary embryonic rat cortical cultures stimulated with IL-6 (20, 30, 40 ng/ml) for 30 minutes (PBS+BSA:negative stimulation control; Okadaic Acid, OA: positive phosphorylation control). Western blot for changes in Akt phosphorylation. *Note membranes for western were cut between 70kd and 50kd*

In vitro bioactivity in cell culture Recombinant Human IL-6 Protein 206-IL
Recombinant Human IL-6 Protein
By Kyle Blackshere on 07/29/2016
Application: In vivo study
Recombinant Human IL-6 Protein
By deborah webb on 05/16/2016
Application: Immunoassay Standard
Recombinant Human IL-6 Protein
By SOjan Abraham on 01/21/2016
Application: In vitro bioactivity in cell culture
Recombinant Human IL-6 Protein
By Anonymous on 01/19/2016
Application: Immunoassay Standard