Recombinant Human NF-L Protein, CF

Recombinant Human NF-L Protein, CF Summary

Product Specifications

Product Datasheets

Carrier Free

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

Background: NF-L

Neurofilament light polypeptide (NF-L), also known as 68 kDa neurofilament protein, and neurofilament triplet L protein, is an approximately 68 kDa member of the neuronal intermediate filament family that plays a role in the maintenance of neuronal caliber and possibly the pathogenesis of motor neuron diseases (1, 2). Out of the three intermediate filament proteins (NF-L, NF-M, NF-H), NF-L is the most abundant. NF-L is a 542 amino acid (aa) cytoskeletal protein which consists of a 91 aa N-terminal head, a 304 aa alpha -helical rod, and a 147 aa C-terminal tail (3). Within the extracellular domains, human NF-L shares 95% and 96% sequence identity with mouse and rat NF-L, respectively.

Related Research Areas

• Cancer Biomarkers
• Cell Structure and Signaling Molecules
• Neurofibrillary Tangle Formation
• Neuronal Lineage Markers
• Neuronal Markers
• Parkinson's Disease Related Molecules