Recombinant Human Tau K18/Tau PHF Core Protein, CF Summary
Product Specifications
Gln244 - Glu372 with a N-terminal Met
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
SP-496
| Formulation | Supplied as a solution in PBS. |
| Shipping | The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Reconstitution Calculator
Background: Tau
Tau is a microtubule-associated protein expressed primarily in neurons. Carboxy-terminal domains of Tau associate with and stabilize microtubule structure, while other domains bind to the plasma membrane. Abnormal Tau phosphorylation may result in the self-assembly of tangles of paired helical and/or straight filaments, which are involved in the pathogenesis of Alzheimer's disease and other neurodegenerative diseases. Properly folded Tau is highly soluble, but when the protein becomes misfolded it forms insoluble aggregates that can damage cytoplasmic functions, interfere with axonal transport and ultimately lead to cell death.
- Billingsley M.L. & Kincaid R.L. (1997) Biochem. J. 323:577.
- Bloom G.S. (2014) JAMA Neurol. 71:505.
- Cripps D. et al. (2006) J. Biol. Chem. 281:10825.
- Harada A. et al. (1994) Nature 369:488.
- Lei P. et al. (2010) Int. J. Biochem. Cell Biol. 42:1775.
- Shamas S.L. et al. (2015) Nat. Comm. 6:7025.
Citations for Recombinant Human Tau K18/Tau PHF Core Protein, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Synthesis and biological evaluation of Halogen-Substituted novel ?-Ketoamides as potential protein aggregation modulators in Alzheimer's disease
Authors: Das, B;Tk Baidya, A;Chakrabarti, S;Chouhan, D;Thakur, B;Darreh-Shori, T;Chen, G;Tiwari, V;Kumar, R;
Bioorganic chemistry
Species: N/A
Sample Types: Small Molecule
Applications: Bioassay -
Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism
Authors: JM Cooper, A Lathuilier, M Migliorini, AL Arai, MM Wani, S Dujardin, SC Muratoglu, BT Hyman, DK Strickland
The Journal of Biological Chemistry, 2021-04-28;0(0):100715.
Species: Hamster, Human
Sample Types: Whole Cells
Applications: Bioassay
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