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Recombinant Human Tau Protein, CF

Catalog #: SP-495
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
SP-495-100
R&D Systems Recombinant Proteins and Enzymes
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Product Details
Citations (6)
FAQs
Reviews
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human Tau Protein, CF Summary

Product Specifications

Purity
>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.
Activity
Concentrations for in vitro assays will depend on experimental conditions and detection methods.
Source
E. coli-derived human Tau protein
Accession #
NP_005901.2
Predicted Molecular Mass
46 kDa

Product Datasheets

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SP-495

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

SP-495

Formulation Supplied as a solution in PBS.
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 6 months from date of receipt, -70 °C as supplied.
  • 3 months, -70 °C under sterile conditions after opening.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Tau

Tau is a microtubule-associated protein expressed primarily in neurons.  Carboxy-terminal domains of Tau associate with and stabilize microtubule structure, while other domains bind to the plasma membrane.  Abnormal Tau phosphorylation may result in the self-assembly of tangles of paired helical and/or straight filaments, which are involved in the pathogenesis of Alzheimer's disease and other neurodegenerative diseases.  Properly folded Tau is highly soluble, but when the protein becomes misfolded it forms insoluble aggregates that can damage cytoplasmic functions, interfere with axonal transport and ultimately lead to cell death.  There are multiple forms of Tau--this 441 amino acid isoform is known as "2N4R," "Isoform Tau-F," "Tau-4" or "Tau 441" and is referenced in UniProt as P10636-8.  This recombinant protein is untagged.

References
  1. Billingsley M.L. & Kincaid R.L. (1997)  Biochem. J.  323: 577
  2. Bloom G.S. (2014) JAMA Neurol.  71: 505
  3. Cripps D. et al. (2006) J. Biol. Chem.  281: 10825
  4. Harada A. et al (1994)  Nature  369: 488
  5. Lei P. et al. (2010)  Int. J. Biochem. Cell Biol.  42: 1775
 
Long Name
Microtubule-Associated Protein Tau
Entrez Gene IDs
4137 (Human); 17762 (Mouse); 29477 (Rat)
Alternate Names
DDPAC; FLJ31424; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPT; MGC138549; microtubule-associated protein tau; MSTD; MSTDMAPTL; MTBT1; MTBT1Neurofibrillary tangle protein; MTBT2; Neurofibrillary tangle protein; PHF-tau; PPND; Tau; TAUPaired helical filament-tau

Citations for Recombinant Human Tau Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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  1. A Combination of Heavy Metals and Intracellular Pathway Modulators Induces Alzheimer Disease-like Pathologies in Organotypic Brain Slices
    Authors: Korde, DS;Humpel, C;
    Biomolecules
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Beta-Amyloid Enhances Vessel Formation in Organotypic Brain Slices Connected to Microcontact Prints
    Authors: Steiner, K;Humpel, C;
    Biomolecules
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  3. In Silico and In Vitro Study towards the Rational Design of 4,4'-Disarylbisthiazoles as a Selective ?-Synucleinopathy Biomarker
    Authors: Uzuegbunam, BC;Li, J;Paslawski, W;Weber, W;Svenningsson, P;Ågren, H;Hooshyar Yousefi, B;
    International journal of molecular sciences
    Species: N/A
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Methylene blue accelerates liquid-to-gel transition of tau condensates impacting tau function and pathology
    Authors: Huang, Y;Wen, J;Ramirez, LM;Gümü?dil, E;Pokhrel, P;Man, VH;Ye, H;Han, Y;Liu, Y;Li, P;Su, Z;Wang, J;Mao, H;Zweckstetter, M;Perrett, S;Wu, S;Gao, M;
    Nature communications
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  5. LRP1 is a neuronal receptor for alpha-synuclein uptake and spread
    Authors: K Chen, YA Martens, A Meneses, DH Ryu, W Lu, AC Raulin, F Li, J Zhao, Y Chen, Y Jin, C Linares, M Goodwin, Y Li, CC Liu, T Kanekiyo, DM Holtzman, TE Golde, G Bu, N Zhao
    Molecular Neurodegeneration, 2022-09-02;17(1):57.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism
    Authors: JM Cooper, A Lathuilier, M Migliorini, AL Arai, MM Wani, S Dujardin, SC Muratoglu, BT Hyman, DK Strickland
    The Journal of Biological Chemistry, 2021-04-28;0(0):100715.
    Species: Hamster, Human
    Sample Types: Whole Cells
    Applications: Bioassay

FAQs

  1. Is Recombinant Human Tau (Catalog # SP-495) phosphorylated?

    • No. Recombinant Human Tau (Catalog # SP-495), which is produced in E.coli, is not phosphorylated.

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