Simple Plex Control for Human NGFR/TNFRSF16

Catalog #: 898345 Datasheet / COA / SDS

Control for Human NGFR/TNFRSF16 Simple Plex Cartridge Kit

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898345

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Simple Plex Control for Human NGFR/TNFRSF16 Summary

INTENDED USE AND DESCRIPTION: For use a quantitative control for the determination of human NGFR/TNFRSF16 concentrations in biological fluids. Controls are supplied lyophilized. Please refer to the lot specific certificate of analysis and Simple Plex Lyophilized Quality Control product insert for additional information.

Specifications

Source

N/A

Shipping Conditions

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Storage

• Store lyophilized controls at 2-8 °C. Lyophilized controls are stable for up to 12 months from date of receipt.
• Reconstituted controls are stable for up to 6 months from date of preparation when stored at ≤ -70 °C. Storage at -20° C is not recommended.
• Individual frozen aliquots of low and high controls are designed as single-use entities. Thaw directly before use and discard any remaining volume.

Applications

Control Simple Plex Automated Immunoassay

Species

Human

Product Datasheets

Product Datasheet

Background: NGFR/TNFRSF16

The low affinity nerve growth factor receptor (NGF R), is a type I transmembrane protein that belongs to the tumor necrosis factor receptor family1 and has been designated TNFRSF16. The NGF receptor is also known as p75 NTR (neurotrophin receptor) because of its ability to bind at low affinity not only to NGF, but also other neurotrophins including brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5. NGF R also binds several myelin derived proteins (Nogo, myelin associated glycoprotein, and myelin oligodendrocyte glycoprotein) as a co-receptor with Nogo receptor.

The NGF receptor is a 75 kDa protein that is expressed in neuronal axons, Schwanns cells and perineural cells of peripheral nerves. Neural crest stem cells have been isolated based on their surface expression of NGF R. In addition, neuroepithelial-derived NGF receptor positive cells have also been demonstrated to be able to differentiate into neurons, smooth muscle and Schwann cells in culture. The expression of the NGF receptor has also been used as a marker to identify mesenchymal precursors as well as hepatic stellate cells.

Long Name

Nerve Growth Factor Receptor

Entrez Gene IDs

4804 (Human); 18053 (Mouse); 117089 (Rat)

Alternate Names

CD271 antigen; CD271; Gp80-LNGFR; member 16; nerve growth factor receptor; NGF R; NGF receptor; NGFR; p75 ICD; p75 NTR; TNFRSF16; TNFRSF16nerve growth factor receptor (TNFR superfamily, member 16); tumor necrosis factor receptor superfamily member 16