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Simple Plex Control for Human TIMP-2

Catalog #: 896947 Datasheet / COA / SDS
Control for use with Human and Non-Human Primate TIMP-2 Simple Plex Assay Cartridge Kit
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896947
Simple Plex Assay Controls
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Simple Plex Control for Human TIMP-2 Summary

INTENDED USE AND DESCRIPTION: For use a quantitative control for the determination of human and NHP TIMP-2 concentrations in biological fluids. Controls are supplied lyophilized. Please refer to the lot specific certificate of analysis and Simple Plex Lyophilized Quality Control product insert for additional information.

Specifications

Source
N/A
Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
• Store lyophilized controls at 2-8 °C. Lyophilized controls are stable for up to 12 months from date of receipt.
• Reconstituted controls are stable for up to 6 months from date of preparation when stored at ≤ -70 °C. Storage at -20° C is not recommended.
• Individual frozen aliquots of low and high controls are designed as single-use entities. Thaw directly before use and discard any remaining volume.
Applications
Control Simple Plex Automated Immunoassay
Species
Human Non-human Primate

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Product Datasheet

Background: TIMP-2

TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.

Long Name
Tissue Inhibitors of Metalloproteinases 2
Entrez Gene IDs
7077 (Human); 21858 (Mouse); 29543 (Rat)
Alternate Names
CSC-21Ktissue inhibitor of metalloproteinase 2; metalloproteinase inhibitor 2; TIMP metallopeptidase inhibitor 2; TIMP2; TIMP-2; Tissue inhibitor of metalloproteinases 2

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