Simple Plex Human Phospho-Tau (T217) ALZpath Cartridge New
Simple Plex Human Phospho-Tau (T217) ALZpath Cartridge Summary
*The Sample Volume represented is based on the amount of sample incorporated into the reaction after taking into account the assay’s minimum required dilution for a given matrix. Serial dilution may be necessary to achieve some of the final sample volumes represented.
Product Summary
Precision
Serum, EDTA Plasma, Heparin Plasma, Cerebrospinal Fluid
| Intra-Assay Precision | Inter-Assay Precision | |||
|---|---|---|---|---|
| Sample | 1 | 2 | 1 | 2 |
| n | 16 | 16 | 66 | 66 |
| Mean (pg/mL) | 8.3 | 444 | 8.7 | 422 |
| Standard Deviation | 0.36 | 19.9 | 0.91 | 38 |
| CV% | 4.3 | 4.5 | 10.5 | 8.9 |
Recovery
Recovery for the Human Phospho-Tau 217 ALZpath assays was evaluated at three different spiked concentrations of p-Tau 217 protein.
| Sample Type | Average % Recovery | Range % |
|---|---|---|
| Cerebrospinal Fluid (n=4) | 138 | 131-142 |
| EDTA Plasma (n=4) | 97 | 83-109 |
| Heparin Plasma (n=4) | 92 | 82-98 |
| Serum (n=4) | 92 | 87-96 |
Linearity
Scientific Data
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Human Phospho-Tau 217 ALZpath Assay Standard Curve Data shown represents typical performance results for Lower Limit of Quantitation (LLOQ) and Upper Limit of Quantitation (ULOQ) for Human Phospho-Tau 217 ALZpath Assay. Assay range is 0.32 to 1,200 pg/mL.
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Human Phospho-Tau 217 ALZpath Assay Endogenous Sample Values EDTA plasma and CSF samples from apparently healthy individuals were tested with the Simple Plex Human Phospho-Tau 217 ALZpath Assay. With this small cohort of samples, 100% detectability of CSF samples was observed and 22% of EDTA plasma samples were detectable above the assays functional limit of detection (LOD) of 0.09 pg/mL. Functional LOD and functional LLOQ are calculated as the LOD and LLOQ of the assay multiplied by the minimum required dilution (MRD) for the sample type.
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Plasma and CSF p-Tau 217 Levels in Alzheimer’s Disease Patients Plasma and CSF p-tau 217 levels of healthy control donors and clinically diagnosed Alzheimer’s disease patients were measured using the Simple Plex Human Phospho-Tau 217 ALZpath Assay. ATN positive patients (ATN+) showed elevated plasma and CSF phosphorylated tau 217 levels when compared to both healthy controls as well as ATN negative patients (ATN-). Significant difference in CSF phosphorylated tau 217 levels was also found upon comparison of ATN+ and Amyloid positive (A+) patient groups.
Product Datasheets
Preparation and Storage
Background: Tau
Tau protein serves as a bridge from microtubules to the plasma membrane to facilitate formation and stabilization of the microtubule network. Tau in PNS neurons is 758 amino acids (aa) in length and 110 kDa in size, but multiple isoforms exist, ranging from 316 to 776 aa in length. Various deletions occur within the first 500 aa, with some isoforms also showing an absence of the second Tau repeat.
FAQs
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