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Tau Antibody

Catalog #: AF3494
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
AF3494
AF3494-SP
Tau in Human Alzheimer's Disease Brain.
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Product Details
Citations (5)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Tau Antibody Summary

Specificity
Detects human Tau in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
E. coli-derived recombinant human Tau
Gln624-Gln756
Accession # P10636
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Human Tau
Immunohistochemistry
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry Tau antibody in Human Alzheimer's Disease Brain by Immunohistochemistry (IHC-P). View Larger

Tau in Human Alzheimer's Disease Brain. Tau was detected in immersion fixed paraffin-embedded sections of human Alzheimer's disease brain (cortex) using 5 µg/mL Goat Anti-Tau Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3494) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Tau

Tau is a microtubule-associated protein primarily expressed in neurons. It can associate with microtubules through the carboxy-terminal domains and with the plasma membrane through the amino-terminal projection domain. Tau has a role as a stabilizer of microtubules. Abnormal Tau phosphorylation or splicing is associated with various neurological disorders.

Long Name
Microtubule-Associated Protein Tau
Entrez Gene IDs
4137 (Human); 17762 (Mouse); 29477 (Rat)
Alternate Names
DDPAC; FLJ31424; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPT; MGC138549; microtubule-associated protein tau; MSTD; MSTDMAPTL; MTBT1; MTBT1Neurofibrillary tangle protein; MTBT2; Neurofibrillary tangle protein; PHF-tau; PPND; Tau; TAUPaired helical filament-tau

Product Datasheets

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Citations for Tau Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. Progressive signaling changes in the olfactory nerve of patients with Alzheimer's disease
    Authors: Bathini P, Mottas A, Jaquet M et al.
    Neurobiol. Aging
  2. Concomitant Neuronal Tau Deposition and FKBP52 Decrease Is an Early Feature of Different Human and Experimental Tauopathies
    Authors: Geri Meduri, Kevin Guillemeau, Corentin Daguinot, Omar Dounane, Melanie Genet, Luigi Ferrara et al.
    Journal of Alzheimer's Disease
  3. Systemic Inflammation Causes Microglial Dysfunction With a Vascular AD phenotype
    Authors: Praveen Bathini, Isabel Dupanloup, Elena Zenaro, Eleonora Terrabuio, Amrei Fischer, Edona Ballabani et al.
    Brain, Behavior, & Immunity - Health
  4. Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease
    Authors: EK Pickett, AG Herrmann, J McQueen, K Abt, O Dando, J Tulloch, P Jain, S Dunnett, S Sohrabi, MP Fjeldstad, W Calkin, L Murison, RJ Jackson, M Tzioras, A Stevenson, M d'Orange, M Hooley, C Davies, M Colom-Cade, A Anton-Fern, D King, I Oren, J Rose, CA McKenzie, E Allison, C Smith, O Hardt, CM Henstridge, GE Hardingham, TL Spires-Jon
    Cell Rep, 2019-12-10;29(11):3592-3604.e5.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  5. Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation
    Authors: Largo-Barrientos P, Apostolo N, Creemers E, et al.
    Neuron

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