Mouse Intestinal Lamina Propria Classical Dendritic Cell Subset Markers

Overview

In the mouse intestinal lamina propria, three major populations of classical dendritic cells (cDCs) have been identified: CD103⁺CD11b^- cDCs, CD103^-CD11b⁺ cDCs, and CD103⁺CD11b⁺ cDCs. All three subsets express CD11c and MHC class II, and lack expression of Fc gamma RI/CD64. The CD103⁺CD11b^- and CD103-CD11b⁺ subsets resemble the CD103⁺CD11b^- and CD103-CD11b⁺ subsets found in other mouse non-lymphoid tissues. For example, CD103⁺CD11b^- cDCs found in the mouse intestine express XCR1 and lack expression of CD11b/Integrin alpha M, CX3CR1, and SIRP alpha/CD172a, while the mouse intestinal CD103^-CD11b⁺ subset uniquely expresses CX3CR1 and lacks expression of XCR1. The CD103⁺CD11b^- and CD103^-CD11b⁺ subsets are the two major cDC subsets found in the mouse colon. In contrast, a CD103⁺CD11b⁺ cDC population is the major subset found in the mouse small intestine. This subset expresses SIRP alpha/CD172a and DCIR2, and lacks expression of both CX3CR1 and XCR1. While the CD103⁺CD11b^- intestinal cDC subset is related to mouse lymphoid tissue resident CD8 alpha⁺ cDCs, the CD103⁺CD11b⁺ cDC subset seems to be related to mouse lymphoid tissue CD11b⁺ cDCs.

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