Hematopoietic Stem Cell Markers
Click on one of the stem cell types shown in the buttons below to see the markers that are commonly used to identify each cell type.
Overview
Hematopoietic stem cells (HSCs) are progenitor cells found in the blood and bone marrow. These multipotent, self-renewing cells give rise to all the cell types found in the blood, including red blood cells, white blood cells, and platelets. Levels of these progenitor cells play a role in cancers of the blood, autoimmune diseases, hematopoiesis, and cell therapies.
Data Examples
Detection of Human Umbilical Cord-derived Hematopoietic Progenitor Cells by Flow Cytometry. Human umbilical cord blood cells were stained using reagents supplied in the Human Hematopoietic Progenitor Cell Multi-Color Flow Kit (R&D Systems, Catalog # FMC019). Cells negative for CD11b/Integrin alpha M and negative/low for CD38 (shown in the boxed area in part A) were gated and assessed for positive expression of CD34 and CD117/c-kit/SCF R (upper right quadrant in part B). Quadrants were set based on staining with the appropriate isotype controls.
Detection of Cell Surface Markers on Hematopoietic Progenitor Cells by Flow Cytometry. Human umbilical cord blood cells were stained with the indicated antibodies included in the Human Hematopoietic Progenitor Cell Multi-Color Flow Kit (R&D Systems, Catalog # FMC019). Representative expression of each analyte in the total umbilical cord blood cell population (filled histograms) is shown over staining with the appropriate isotype controls (open histograms).