Neuroinflammation is a pathological feature of a wide range of neurodegenerative diseases and neurological disorders. It is an inflammatory reaction within nervous tissue that arises as a protective mechanism from toxic stimuli. This brochure describes the events that occur during neuroinflammation and the continuous cycle that can transpire when the neuroinflammatory reaction becomes chronic. It also details the large portfolio of research tools that the Bio-Techne brands, R&D Systems, Novus Biologicals, Tocris, ProteinSimple and ACD, offer to investigate the different steps of neuroinflammation.
- Immunocytochemistry/Immunohistochemistry-validated antibodies for markers of quiescent and activated microglia and astrocytes
- Recombinant proteins and small molecules for activating and polarizing glial cells
- Single and multiplex immunoassays for detecting and quantifying neuroinflammation markers
- Small molecules for investigating inflammatory signaling pathways
- Antibodies and immunoassays for detecting and evaluating blood-brain barrier breakdown
- Flow cytometry-validated antibodies for identifying peripheral immune cells in neural tissue
- RNAscope™ assays for spatially mapping neuroinflammation markers and cell types in neural tissue
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