Cadherin-4/R-Cadherin: Products
Cadherin-4, also known as R-Cadherin, is a 120-140 kDa type I transmembrane protein belonging to the Cadherin superfamily of calcium-dependent adhesion molecules. Cadherin-4 is expressed in epithelial cells, vascular smooth muscle cells, glial and neuronal cells, pancreatic beta-cells, thyroid follicular cells, and bone marrow Lin- hematopoietic stem cells. It interacts in cis to form homodimers as well as heterodimers with N-Cadherin which function as adhesion multimers in trans-configuration. It is downregulated in invasive breast cancer but upregulated in rhabdomyosarcoma and has been shown to exert both positive and negative effects on cell migration and tumor cell invasiveness.
Cadherin-4 is involved in a variety of homing processes including guidance of the optic nerve and pioneer axons in early brain development, branching and guidance of the retinal vasculature, and targeting of hematopoietic stem cells to sites of ischemia. Cadherin-4 additionally binds to KLRG1, an inhibitory receptor expressed on NK cells.
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