CCR1L1: Products

CCR1L1 is a murine-specific G protein-coupled receptor member of the CC chemokine subfamily of receptors. Mouse CCR1L1 is 356 amino acids in length with a predicted molecular weight of 41 kDa. Most chemokine receptors exhibit promiscuous binding properties whereby several different chemokines signal through the same receptor. Chemokine ligand receptor binding results in G protein activation as well as the activation of downstream signaling cascades including the Akt and NFkB pathways. Chemokine receptors mediate the chemotactic actions of chemokine ligands and activation of these receptors leads to cytoskeleton rearrangement and chemotactic cell migration.