EBF-1: Products

EBF-1 (Early B cell Factor 1; also OLF1 and COE1) is a 65-70 kDa member of the COE family of transcription factors. Although expressed in adipocytes and neurons, it is best studied in B cells where IL-7 acts to promote EBF-1 in pre-proB cells, leading to proB stage development. Mouse EBF-1 is 591 amino acids (aa) in length. It contains one DNA-binding region with an embedded zinc-finger motif (aa 51-235), a dimerization segment between aa 370-430, and a Pro/Ser-rich transactivation domain (aa 462-550). EBF-1 either homodimerizes, or heterodimerizes with EBF-2 and -3. There is an alternate start site at Met134, and an isoform that shows a one aa substitution for aa 252-259. Over aa 416-520, mouse EBF-1 shows absolute aa identity to the equivalent sequence in rat and human EBF-1.