IL-15R alpha: Products
IL-15Ra (Interleukin 15 Receptor alpha), also known as CD215, is a transmembrane glycoprotein that plays an important role in NK and CD8+ memory T cell homeostasis and activation. It transmits IL-15 induced signals and additionally interacts with a complex of IL-2Rβ and the common gamma chain (γc) which are also subunits of the IL-2 receptor complex.
In transpresentation, IL-15/IL-15Ra complexes are expressed on the surface of one cell and interact with complexes of IL-2Rb/gc on adjacent cells. IL-15/IL-15Ra complexes can transmit reverse signaling that promotes adhesion and activation of the IL-15/IL-15Ra expressing cells. Shed soluble forms of IL-15Ra retain the ability to bind tightly to IL-15 and can inhibit IL-15 bioactivity.
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