Mouse ADAM19 Ectodomain Antibody

Catalog #: MAB1229 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB1229
MAB1229-SP

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse ADAM19 Ectodomain Antibody Summary

Species Reactivity

Mouse

Specificity

Detects mouse ADAM19 Ectodomain in direct ELISAs and Western blots. It also recognizes a C-terminal fragment (amino acids 588‑705) of recombinant mouse (rm) ADAM19 in Western blots. In Western blots, no cross-reactivity with rmADAM10 or rmADAM15 is observed.

Source

Monoclonal Rat IgG_2A Clone # 164646

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse ADAM19 Ectodomain
Asp205-Gly705 (predicted)
Accession # O35674

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

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Citations (17)

Applications

Recommended Concentration

Sample

Western Blot

1 µg/mL

Recombinant Mouse ADAM19 Ectodomain

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Reconstitution Buffer Available

Reconstitution Buffer 1 (PBS)

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: ADAM19

ADAM19 (a disintegrin and metalloprotease 19; also MADDAM and Meltrin-beta ) is a 95‑100 kDa member of the M12B peptidase family of enzymes. It is expressed on multiple cell types including monocytes, fibroblasts, osteoblasts and dendritic cells. After cleavage of a signal sequence and prodomain, the ectodomain circulates in plasma bound to alpha 2-Macroglobulin. ADAM19 cleaves at sequences present in myelin basic protein, insulin beta chain, TNF-alpha, TRANCE and SCF. Over amino acids (aa) 205‑705, mouse ADAM19 shares 87% aa sequence identity with human ADAM19.

Long Name

A Disintegrin and Metalloprotease-like Domain 19

Entrez Gene IDs

8728 (Human); 11492 (Mouse)

Alternate Names

a disintegrin and metalloproteinase domain 19 (meltrin beta); ADAM 19; ADAM metallopeptidase domain 19; ADAM19; disintegrin and metalloproteinase domain-containing protein 19; EC 3.4.24; EC 3.4.24.-; MADDAM; Meltrin beta; meltrin-beta; Metalloprotease and disintegrin dendritic antigen marker; MLTNBmeltrin beta