FRS2: Products

FRS2 (FGF R substrate 2; also known as SNT and FRS2 alpha) is a 70-90 kDa member of the FRS family of lipid-anchored docking proteins. It is an intermediary between FGF R and other RTK receptors and their Ras/MAPK signaling cascades. FRS2 contains a membrane-anchoring myristoylation signal (aa 1-6), a PTB domain (aa 13-115) that interacts with FGF and NGF receptors, and a C-terminal Tyr-rich region (aa 196-471) that serves as a docking site for GRB-2 and SHP-2.