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2R,6R-Hydroxynorketamine hydrochloride

Catalog #: 6094
10 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6094/10
2R,6R-Hydroxynorketamine hydrochloride | CAS No. 1430202-69-9 | AMPA Receptor Agonists
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Description: Enhances AMPA currents; decreases D-serine (a NMDA co-agonist); lacks ketamine-related side effects

Chemical Name: (2R,6R)-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride

Purity: ≥98%

Product Details
Citations (10)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

2R,6R-Hydroxynorketamine hydrochloride is a ketamine metabolite. It enhances AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices and decreases intracellular D-serine (a NMDA co-agonist) concentrations in PC-12 cells (IC50 = 0.68 nM). 2R,6R-Hydroxynorketamine upregulates KCNQ2 channels in mouse ventral hippocampal glutamatergic neurons in vitro and in vivo. Exerts antidepressant effects in mice. Lacks ketamine-related side effects.

2S,6S-Enantiomer and Racemate also available.

Technical Data

M.Wt:
276.16
Formula:
C12H14ClNO2.HCl
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
1430202-69-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the NIH, US patent 62/313,309
Other Product-Specific Information:

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Citations for 2R,6R-Hydroxynorketamine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for 2R,6R-Hydroxynorketamine hydrochloride include:

10 Citations: Showing 1 - 10

  1. Ketamine and its metabolite 2R,6R-hydroxynorketamine promote ocular dominance plasticity and release tropomyosin-related kinase B from inhibitory control without reducing perineuronal nets enwrapping parvalbumin interneurons.
    Authors: Plinio C Et al.
    Eur J Neurosci  2023;57:940-950
  2. TRKB interaction with PSD95 is associated with latency of fluoxetine and 2R,6R-hydroxynorketamine.
    Authors: Eero Et al.
    Eur J Neurosci  2023;57:1215-1224
  3. Psychedelics promote plasticity by directly binding to BDNF receptor TrkB.
    Authors: Tomasz Et al.
    Nat Neurosci  2023;26:1032-1041
  4. Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro.
    Authors: Eero Et al.
    Front Pharmacol  2022;12:755600
  5. Subanesthetic Ketamine Reactivates Adult Cortical Plasticity to Restore Vision from Amblyopia.
    Authors: Xiangmin Et al.
    Curr Biol  2020;30:3591-3603.e8
  6. The Ventrolateral Periaqueductal Gray Contributes to Depressive-Like Behaviors in Recovery of Inflammatory Bowel Disease Rat Model.
    Authors: Jian-Hua Et al.
    Front Neurosci  2020;14:254
  7. Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2.
    Authors: Eero Et al.
    J Biol Chem  2019;294:18150-18161
  8. (R)-Ketamine induces a greater increase in prefrontal 5-HT release than (S)-Ketamine and Ketamine Metabolites via an AMPA receptor-independent mechanism.
    Authors: Ago Et al.
    Int J Neuropsychopharmacol  2019;22:665
  9. KA metabolite (2R,6R)-hydroxynorKA enhances aggression via periaqueductal gray glutamatergic transmission.
    Authors: Ye Et al.
    Neuropharmacology  2019;157
  10. (2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray.
    Authors: Chou Et al.
    Neuropharmacology  2018;139:1

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