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2S,6S-Hydroxynorketamine hydrochloride

Catalog #: 6095
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6095/10
2S,6S-Hydroxynorketamine hydrochloride | CAS No. 1430202-70-2 | AMPA Receptor Agonists
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Description: Decreases D-serine (a NMDA co-agonist); antidepressant

Chemical Name: (2S,6S)-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

2S,6S-Hydroxynorketamine hydrochloride is a ketamine metabolite. Decreases intracellular D-serine (a NMDA co-agonist) concentrations in PC-12 cells (IC50 = 0.18 nM). Exerts antidepressant effects in mice.

2R,6R-Enantiomer and Racemate also available.

Technical Data

M.Wt:
276.16
Formula:
C12H14ClNO2.HCl
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
1430202-70-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the NIH, US patent 62/313,309
Other Product-Specific Information:

Product Datasheets

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Citations for 2S,6S-Hydroxynorketamine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for 2S,6S-Hydroxynorketamine hydrochloride include:

4 Citations: Showing 1 - 4

  1. Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro.
    Authors: Eero Et al.
    Front Pharmacol  2022;12:755600
  2. (R)-Ketamine induces a greater increase in prefrontal 5-HT release than (S)-Ketamine and Ketamine Metabolites via an AMPA receptor-independent mechanism.
    Authors: Ago Et al.
    Int J Neuropsychopharmacol  2019;22:665
  3. KA metabolite (2R,6R)-hydroxynorKA enhances aggression via periaqueductal gray glutamatergic transmission.
    Authors: Ye Et al.
    Neuropharmacology  2019;157
  4. (2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray.
    Authors: Chou Et al.
    Neuropharmacology  2018;139:1

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