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CoraFluor™ 2, Haloalkane

Catalog #: 8818 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8818/20U
CoraFluor™ 2, Haloalkane | Fluorescent Probes
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Description: Cell permeable terbium cryptate FRET donor for TR-FRET assay development, with chloroalkane ligand
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Biological Activity

CoraFluor™ 2, Haloalkane is a cell permeable terbium-based time-resolved Förster resonance energy transfer (TR-FRET) donor for live cell TR-FRET assay development, such as target engagement and ternary complex assays. CoraFluor™ 2, Haloalkane is designed with a chloroalkane ligand for reactivity with haloalkane dehalogenase labeled proteins. CoraFluor™ 2, Haloalkane can be used in live cell intracellular TR-FRET assays. It is exceptionally bright, providing unmatched assay sensitivity and stability in biological media over other commercially available TR-FRET donors. CoraFluor™ 2, Haloalkane displays red shifted excitation and is excitable by both 365 nm and 405 nm lasers. It is compatible with common acceptor dyes such as FAM/FITC, AF488, GFP, mCherry, TMR and Cyanine 5, SE (Cat. No. 5436), enabling seamless assay integration in high throughput screening applications.

CoraFluor™ 1, Haloalkane, CoraFluor™ 1, thiol reactive, CoraFluor™ 1, amine reactive and CoraFluor™ 2, amine reactive also available.

CoraFluor is a trademark of Bio-Techne Corp.

Scientific Data

Binding Activity Live cell TR-FRET assay View Larger

Live cell TR-FRET assay. Cellular dose-dependent inhibition of HDAC1-dehalogenase fusion protein labeled with CoraFluor™ 2, Haloalkane in HEK293T cells by various HDAC inhibitors (treatment for 4 h at 37 °C, 1 μM SAHA-NCT).

Optical Data for CoraFluor™ 2, Haloalkane

CoraFluor™ 2, Haloalkane Dye Spectra
λabs 356 nm
Extinction Coefficient (ε) 15900 M-1cm-1
Quantum Yield (φ) 0.35
Closest Laser line 337 nm
Cell Permeable Yes
Application Time-resolved fluorescence energy transfer (TR-FRET)

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

Spectral Viewer

Spectral Viewer

Technical Data

M.Wt:
1662.7
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Product Datasheets

Reconstitution Calculator
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Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.