Home / Activin RIIB / Human Activin RIIB Antibody

Human Activin RIIB Antibody

Catalog #: MAB3392
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB3392-SP
MAB3392-500
MAB3392-100
Product Details
Citations (2)
FAQs
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Activin RIIB Antibody Summary

Species Reactivity
Human
Specificity
Detects human Activin RIIB in direct ELISAs and Western blots. Shows approximately 5% cross‑reactivity with recombinant human Activin RIIA.
Source
Monoclonal Mouse IgG1 Clone # 60408
Purification
Protein A or G purified from ascites
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Activin RIIB
Ser19-Thr134
Accession # CAA54671
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human Activin RIIB Fc Chimera (Catalog # 339-RB)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Activin RIIB

Members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction. Activin receptor type IIB is a type II receptor that mediates multiple signals for transforming growth factor-beta (TGF-beta ) family members, including Activin, Nodal, BMP-7, GDF-1, GDF-3, Myostatin (GDF-8), and GDF-11. Through alternative mRNA splicing, multiple ActR-IIB isoforms can also be generated.

Long Name
Activin Receptor IIB
Entrez Gene IDs
93 (Human); 11481 (Mouse)
Alternate Names
activin A receptor, type IIB; Activin receptor type IIB; activin receptor type-2B; Activin RIIB; ActivinRIIB; ACTRIIB; ActR-IIB; ACVR2B; EC 2.7.11; EC 2.7.11.30; MGC116908

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Citations for Human Activin RIIB Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. CellCall: integrating paired ligand-receptor and transcription factor activities for cell-cell communication
    Authors: Y Zhang, T Liu, X Hu, M Wang, J Wang, B Zou, P Tan, T Cui, Y Dou, L Ning, Y Huang, S Rao, D Wang, X Zhao
    Nucleic Acids Research, 2021-09-07;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  2. Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer
    Authors: Bajikar SS, Wang CC, Borten MA et al.
    Dev. Cell.

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