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Human Chondromodulin-1 Antibody

Catalog #: MAB41681
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB41681
MAB41681-SP
Product Details
Citations (2)
FAQs
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Chondromodulin-1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human Chondromodulin‑1 in direct ELISAs and Western blots.
Source
Monoclonal Mouse IgG2B Clone # 394002
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Chondromodulin‑1 mature chain
Glu215-Val333
Accession # NP_001011705.1
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human Chondromodulin‑1

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Chondromodulin-1

Chondromodulin-1 (ChM-1), also known as Lect1, is a type II transmembrane protein that is cleaved intracellularly resulting in the secretion of a 25 kDa molecule. ChM-1 is expressed in avascular cartilage, cardiac valves, and the eye. The antiangiogenic properties of ChM-1 can block tumor progression and the pathological vascularization of cardiac valves. Human ChM-1 shares 89%‑92% aa sequence identity with bovine, mouse, rabbit, and rat ChM-1.

Entrez Gene IDs
11061 (Human); 16840 (Mouse); 81512 (Rat)
Alternate Names
BRICD3; BRICHOS domain containing 3; ChM-1; CHM1chondromodulin I; CHMI; CHM-I; chondromodulin; Chondromodulin1; Chondromodulin-1; chondromodulin-I; LECT1; leukocyte cell derived chemotaxin 1; Leukocyte cell-derived chemotaxin 1; multiple myeloma tumor suppressor 1; MYETS1

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Citations for Human Chondromodulin-1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Gene Expression Changes in Steroid-Induced IOP Elevation in Bovine Trabecular Meshwork
    Authors: John Danias, Rosana Gerometta, Yongchao Ge, Lizhen Ren, Lampros Panagis, Thomas W. Mittag et al.
    Investigative Opthalmology & Visual Science
  2. 4-HNE inhibits tube formation and up-regulates chondromodulin-I in human endothelial cells.
    Authors: Stagos D, Zhou H, Ross D, Vasiliou V
    Biochem. Biophys. Res. Commun., 2008-12-03;379(3):654-8.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot

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