Human Claudin-19 Antibody Summary
Accession # Q8N6F1
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Claudin-19 in Human Kidney Cancer Tissue. Claudin-19 was detected in immersion fixed paraffin-embedded sections of human kidney cancer tissuer using Mouse Anti-Human Claudin-19 Monoclonal Antibody (Catalog # MAB6970) at 8 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to the cytoplasm and plasma membranes of epithelial cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Claudin-19
Claudin-19 is a 23 kDa multipass membrane protein in the Claudin family of epithelial tight junction proteins. Claudin-19 is expressed by renal tubular epithelial cells, retinal pigment epithelial cells, and Schwann cells. It interacts with Claudin-16 to form cation-selective paracellular channels in the thick ascending loop of the kidney. Mutations of Claudin-19 are associated with renal disorders of magnesium and calcium reabsorption. Human Claudin-19 shares 95% aa sequence identity with mouse and rat Claudin-19. An alternate splice form of human Claudin-19 has a deletion within the C-terminal cytoplasmic region.
Product Datasheets
Citations for Human Claudin-19 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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Novel Human Induced Pluripotent Stem Cell-Based Model for Retinal Pigment Epithelial Cells to Reveal Possible Disease Mechanisms for Macular Degeneration in Pseudoxanthoma Elasticum
Authors: Viheriälä, T;Hongisto, H;Saari, L;Oksanen, M;Ilmarinen, T;Väärämäki, S;Uusitalo, H;Nevalainen, P;Skottman, H;
Journal of ophthalmology
Species: Human
Sample Types: Whole Cells
Applications: Immunocytochemistry -
Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients
Authors: Karema-Jokinen, V;Koskela, A;Hytti, M;Hongisto, H;Viheri�l�, T;Liukkonen, M;Torsti, T;Skottman, H;Kauppinen, A;Nymark, S;Kaarniranta, K;
The Journal of biological chemistry
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Culture surface protein coatings affect the barrier properties and calcium signalling of hESC-RPE
Authors: T Viheriälä, J Sorvari, TO Ihalainen, A Mörö, P Grönroos, S Schlie-Wol, B Chichkov, H Skottman, S Nymark, T Ilmarinen
Scientific Reports, 2021-01-13;11(1):933.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Human RPE stem cells grown into polarized RPE monolayers on a polyester matrix are maintained after grafting into rabbit subretinal space.
Authors: Stanzel B, Liu Z, Somboonthanakij S, Wongsawad W, Brinken R, Eter N, Corneo B, Holz F, Temple S, Stern J, Blenkinsop T
Stem Cell Reports, 2014-01-02;2(1):64-77.
Species: Human
Sample Types: Whole Cells
Applications: ICC
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