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Human CRHR-1 Antibody

Catalog #: MAB3930
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB3930
MAB3930-SP
Product Details
Citations (2)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human CRHR-1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human CRHR‑1 transfectants but not irrelevant transfectants.
Source
Monoclonal Mouse IgG2A Clone # 343919
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
NS0 mouse myeloma cell line transfected with human CRHR-1
Ser24-Val415
Accession # NP_004373
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Flow Cytometry
2.5 µg/106 cells
Human CRHR‑1 transfected Ba/F3 cells
Immunohistochemistry
8-25 µg/mL
Immersion fixed paraffin-embedded sections of human placenta
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CRHR1

Corticotrophin-Releasing Hormone Receptor 1 (CRHR-1), also known as CRFR-1, is a 7TM protein that belongs to the G protein-coupled receptor family 2. CRHR-1 is expressed in the brain and adrenal gland where it mediates corticotropin-induced effects on anxiety, depression, and stress-associated pathologies. The immunogen for this antibody corresponds to one of the four alternately spliced forms and has a 29 amino acid deletion in the first cytoplasmic domain. Human CRHR-1 shares 97% amino acid sequence identity with mouse and rat CRHR-1.

Long Name
Corticotropin Releasing Hormone Receptor 1
Entrez Gene IDs
1394 (Human); 12921 (Mouse)
Alternate Names
CHR-R1; corticotropin releasing hormone receptor 1; corticotropin-releasing factor receptor 1; corticotropin-releasing factor type 1 receptor; Corticotropin-releasing hormone receptor 1; CRF1; CRFR; CRF-R; CRFR1; CRF-R1; CRF-R-1; CRFR-1; CRHR1; CRH-R-1; CRHR1f; CRH-R1h; CRHR1L; CRHRCRH-R1; seven transmembrane helix receptor

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Citations for Human CRHR-1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Conformation-specific monoclonal antibodies recognizing the native structure of G protein-coupled receptor (GPCR)
    Authors: Y Isozaki, K Tsumoto, M Tomita
    International immunopharmacology, 2021-06-25;98(0):107872.
    Species: Chinese Hamster
    Sample Types: Whole Cells
    Applications: IHC
  2. IGFBP2 Plays an Essential Role in Cognitive Development during Early Life
    Authors: Shumsuzzaman Khan, Xinjiang Lu, Qingyao Huang, Jiawei Tang, Jian Weng, Zhi Yang et al.
    Advanced Science

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