Human IFN-beta Antibody

Catalog #: 21450-1
2 Citations Datasheet / COA / SDS

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21450-1

All IFN-beta Antibodies

Product Details

Citations (2)

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human IFN-beta Antibody Summary

Species Reactivity

Human

Specificity

Detects human interferon beta in direct ELISAs.

Source

Monoclonal Mouse IgG₁ Clone # MMHB-12

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Human interferon beta

Formulation

Phosphate buffered saline (PBS) containing 0.1% bovine serum albumin (BSA)

Label

Unconjugated

Applications

Recommended Concentration

Sample

Direct ELISA

Binds to human interferon beta with high affinity.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

After receipt, the product may be stored at -20°C for short-term use ( ≤ 6 months). For long-term storage, we recommend storing the product at -70°C or below for retention of full activity. When thawing, the contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum. Refreezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers containing protein such as 0.1% bovine serum albumin (BSA).

Background: IFN-beta

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

Long Name

Interferon beta

Entrez Gene IDs

3456 (Human); 15977 (Mouse); 24481 (Rat)

Alternate Names

Fibroblast interferon; IFB; IFBIFNB; IFF; IFNB; IFNB1; IFNbeta; IFN-beta; interferon beta; interferon, beta 1, fibroblast; MGC96956

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citations for Human IFN-beta Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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Neutralizing type I IFN antibodies trigger an IFN-like response in endothelial cells.
Authors: Moll HP, Freudenthaler H, Zommer A
J. Immunol., 2008-04-15;180(8):5250-6.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization
TLR7 Agonist 852A Inhibition of Tumor Cell Proliferation Is Dependent on Plasmacytoid Dendritic Cells and Type I IFN.
Authors: Inglefield JR, Dumitru CD, Alkan SS, Gibson SJ, Lipson KE, Tomai MA, Larson CJ, Vasilakos JP
J. Interferon Cytokine Res., 2008-04-01;28(4):253-63.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization