Human IL-17RB Antibody Summary
Arg18-Gly289
Accession # Q9NRM6
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
View Larger
Detection of IL‑17 RB in K562 Human Cell Line by Flow Cytometry. K562 human chronic myelogenous leukemia cell line was stained with Mouse Anti-Human IL-17 RB Monoclonal Antibody (Catalog # MAB1207, filled histogram) or isotype control antibody (Catalog # MAB0041, open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B).
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-17RB
The interleukin 17 (IL-17) family of cytokines, comprising six members (IL-17, IL-17B through IL-17F), are structurally related proteins with a conserved cysteine-knot structure. These proinflammatory cytokines can induce local cytokine productions and are involved in the regulation of the immune response. The cognate receptors activated by some of these cytokines have been identified (1). Interleukin-17 B Receptor (IL-17 RB), also known as IL-17Rh1, IL-17ER and EVI27, represents the second receptor of the IL-17 family of cytokines to be recognized (2-4). Human IL-17 RB cDNA encodes a 502 amino acid (aa) residue type I membrane protein with a putative 17 aa signal peptide, a 275 aa extracellular domain, a 21 aa transmembrane domain and a 189 aa cytoplasmic tail. By alternative splicing, a secreted variant of IL-17 RB has also been identified (4). Human and mouse IIL-17 RB share 76% aa sequence identity. The human IL-17 RB protein sequence is only 19.2% identical to the human IL-17 R sequence, but the two receptors share many conserved cysteine residues within their extracellular domains as well as additional conserved elements within their cytoplasmic domains. Three additional type I transmembrane receptors with homology to IL-17 R have been reported, increasing the number of the IL-17 R family members to five (5, 6). By Northern blot analysis, human IL-17 RB is highly expressed in kidneys and liver but is expressed at lower levels in testes, brain, small intestine and other endocrine tissues (2-4). The expression of IL-17 RB is significantly up-regulated under inflammatory conditions. IL-17 RB binds strongly to IL-17E and weakly to IL-17B. It does not bind IL-17, IL-17C, and IL-17F. Activation of IL-17 RB by its ligands results in the activation of nuclear factor kappa-B (2-4).
- Aggarwal, S. and A.L. Gurney (2002) J. Leukoc. Biol. 71:1.
- Shi Y, et al. (2000) J. Biol. Chem. 275:19167.
- Lee, J, et al. (2001) J. Biol. Chem. 276:1660.
- Tian E, et al. (2000) Oncogene 19:2098.
- Haudenschild, D. et al. (2002) J. Biol. Chem. 277:4309.
- Hurst, S.D. et al. (2002) J. Immunol. 169:443.
Product Datasheets
Citations for Human IL-17RB Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
7
Citations: Showing 1 - 7
Filter your results:
Filter by:
-
IL-25 blockade augments antiviral immunity during respiratory virus infection
Authors: Teresa C. Williams, Su-Ling Loo, Kristy S. Nichol, Andrew T. Reid, Punnam C. Veerati, Camille Esneau et al.
Communications Biology
-
Combinatorial IL-17RB, ST2, and TSLPR Signaling in Dendritic Cells of Patients With Allergic Rhinitis
Authors: Rui Zheng, Yang Chen, Jianbo Shi, Kai Wang, Xuekun Huang, Yueqi Sun et al.
Frontiers in Cell and Developmental Biology
-
IL-17RB(+) granulocytes are associated with airflow obstruction in asthma
Authors: Lin Li
Ann. Allergy Asthma Immunol, 2016-12-01;117(6):674-679.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-1?, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs
Authors: SM Bal, JH Bernink, M Nagasawa, J Groot, MM Shikhagaie, K Golebski, CM van Drunen, R Lutter, RE Jonkers, P Hombrink, M Bruchard, J Villaudy, JM Munneke, W Fokkens, JS Erjefält, H Spits, XR Ros
Nat Immunol, 2016-04-25;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells.
Authors: Islam SA, Chang DS, Colvin RA
Nat. Immunol., 2011-01-09;12(2):167-77.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-25 in atopic dermatitis: a possible link between inflammation and skin barrier dysfunction?
Authors: Hvid M, Vestergaard C, Kemp K
J. Invest. Dermatol., 2010-09-23;131(1):150-7.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts.
Authors: Létuvé S, Lajoie-Kadoch S, Audusseau S, Rothenberg ME, Fiset PO, Ludwig MS, Hamid Q
J. Allergy Clin. Immunol., 2006-02-08;117(3):590-6.
Species: Human
Sample Types: Cell Lysates, Whole Cells
Applications: ICC, Western Blot
FAQs
No product specific FAQs exist for this product, however you may
View all Antibody FAQsReviews for Human IL-17RB Antibody
Average Rating: 4.7 (Based on 3 Reviews)
Have you used Human IL-17RB Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
