Human IL-18/IL-1F4 Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
Background: IL-18/IL-1F4
Interleukin 18 (IL-18) is a 18 kDa cytokine which identified as a costimulatory factor for production of interferon-gamma (IFN-gamma ) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24 kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE, Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. IFN-gamma is produced by activated T or NK cells and plays critical roles in the defense against microbiral pathogens. IFN-gamma activates macrophages, enhances NK activity and B cell maturation, proliferation and Ig secretion, induces MHC class I and II antigens, and inhibits osteoclast activation. IL-18 acts on T helper type-1 (Th1) T cells and in combination with IL-12 strongly induces them to produce IFN-gamma. Pleiotropic effects of IL-18 has also been reported, such as, enhancement production of IFN-gamma and GM-CSF in peripheral blood mononuclear cells, production of Th1 cytokines, IL-2, GM-CSF and IFN-gamma in T cells, enhancement of Fas ligand expression by Th1 cells.
- McCurnin, D., et al., Pediatrics 121, 945-956 (2008)
- Haveman, L. M., et al., Int. Immunol. 18, 1521-1529 (2006)
- Shigehara, K., et al., J. Immunol. 166, 642-649 (2001)
- Dao, T., et al. Cell Immunol. 173, 230-235 (1996)
- Micallef, M., et al. Eur. J. Immunol. 26, 1647-1651 (1996)
- Ushio, S., et al. J. Immunol. 156, 4274-4279 (1996)
- Okamura, H., et al. Nature 378, 88-91 (1995)
Product Datasheets
Citations for Human IL-18/IL-1F4 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
9
Citations: Showing 1 - 9
Filter your results:
Filter by:
-
AIM2 inflammasome mediates Arsenic-induced secretion of IL-1 beta and IL-18
Authors: Mingfang Zhang, Yuanlin Qi, Hui Li, Jiajun Cui, Lu Dai, Jacqueline A. Frank et al.
OncoImmunology
-
Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin.
Authors: Valente AJ, Yoshida T, Izadpanah R et al.
Cell Signal.
-
The Nox1/4 Dual Inhibitor GKT137831 or Nox4 Knockdown Inhibits Angiotensin-II-Induced Adult Mouse Cardiac Fibroblast Proliferation and Migration. AT1 Physically Associates With Nox4
Authors: Naveen K. Somanna, Anthony J. Valente, Maike Krenz, William P. Fay, Patrice Delafontaine, Bysani Chandrasekar
Journal of Cellular Physiology
-
Surface cysteine to serine substitutions in IL-18 reduce aggregation and enhance activity
Authors: J Saetang, N Roongsawan, S Sangkhatha, SP Voravuthik, N Sangkaew, N Prompat, T Srichana, V Tipmanee
PeerJ, 2022-07-05;10(0):e13626.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Zinc inhibits high glucose-induced NLRP3 inflammasome activation in human peritoneal mesothelial cells
Authors: Y Fan, X Zhang, L Yang, J Wang, Y Hu, A Bian, J Liu, J Ma
Mol Med Rep, 2017-08-11;0(0):.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Resveratrol blocks interleukin-18-EMMPRIN cross-regulation and smooth muscle cell migration.
Authors: Venkatesan B, Valente AJ, Reddy VS, Siwik DA, Chandrasekar B
Am. J. Physiol. Heart Circ. Physiol., 2009-06-26;297(2):H874-86.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Clinical improvement in chronic plaque-type psoriasis lesions after narrow-band UVB therapy is accompanied by a decrease in the expression of IFN-gamma inducers -- IL-12, IL-18 and IL-23.
Authors: Piskin G, Tursen U, Sylva-Steenland RM, Bos JD, Teunissen MB
Exp. Dermatol., 2004-12-01;13(12):764-72.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-Fr -
Cytokine profile of the rheumatoid nodule suggests that it is a Th1 granuloma.
Authors: Hessian PA, Highton J, Kean A, Sun CK, Chin M
Arthritis Rheum., 2003-02-01;48(2):334-8.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Histone deacetyltransferase inhibitors Trichostatin A and Mocetinostat differentially regulate MMP9, IL-18 and RECK expression, and attenuate Angiotensin II-induced cardiac fibroblast migration and proliferation
Authors: Naveen K Somanna, Anthony J Valente, Maike Krenz, Kerry S McDonald, Yusuke Higashi, Makoto Noda et al.
Hypertension Research
FAQs
No product specific FAQs exist for this product, however you may
View all Antibody FAQsIsotype Controls
Secondary Antibodies
Reviews for Human IL-18/IL-1F4 Antibody
Average Rating: 5 (Based on 1 Review)
Have you used Human IL-18/IL-1F4 Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
