Human ITIH2 Antibody

Catalog #: MAB101992 Datasheet / COA / SDS

Recombinant Monoclonal Antibody

Catalog #	Availability	Size / Price	Qty
MAB101992-SP	Ships in 5-7 Days	25 ug / $149
MAB101992-100	In Stock	100 ug / $379

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ITIH2 in SARS-CoV-2 Infected Human Lung.

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All ITIH2 Antibodies

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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human ITIH2 Antibody Summary

Species Reactivity

Human

Specificity

Detects human ITIH2 in direct ELISAs.

Source

Recombinant Monoclonal Rabbit IgG Clone # 2688A

Purification

Protein A or G purified from cell culture supernatant

Immunogen

Spodoptera frugiperda Sf 9 (baculovirus)-derived human ITIH2
Ser55-Asp702
Accession # P19823

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Label

Unconjugated

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Applications

Recommended Concentration

Sample

Immunohistochemistry

5-25 µg/mL

Immersion fixed paraffin-embedded sections of SARS-CoV-2 infected human lung

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry

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ITIH2 in SARS-CoV-2 Infected Human Lung. ITIH2 was detected in immersion fixed paraffin-embedded sections of SARS-CoV-2 infected human lung using Rabbit Anti-Human ITIH2 Monoclonal Antibody (Catalog # MAB101992) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Rabbit IgG VisUCyte™ HRP Polymer Antibody (VC003). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in hepatocytes. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Reconstitution Buffer Available

Reconstitution Buffer 1 (PBS)

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: ITIH2

The ITIs are a family of plasma protease inhibitors contributing to extracellular matrix stabilization by covalent linkage to hyaluronan. ITIH2 is a binding protein between hyaluronan and other matrix proteins. It regulates the localization, synthesis and degradation of hyaluronan. ITIH molecules are shown to play a role in carcinogenesis and inflammation. ITIH genes are downregulated in multiple human solid tumors. This downregulation contributes to initiation and/or progression of malignancy.

Long Name

Inter-Alpha-Trypsin Inhibitor Heavy Chain 2

Entrez Gene IDs

3698 (Human); 16425 (Mouse)

Alternate Names

H2P; IGHEP2; Inter-Alpha (Globulin) Inhibitor H2; inter-alpha (globulin) inhibitor, H2 polypeptide; Inter-alpha-inhibitor heavy chain 2; Inter-alpha-trypsin inhibitor complex component II; inter-alpha-trypsin inhibitor heavy chain H2; Intin2; ITI Heavy Chain H2; ITIH2; ITI-H2; ITI-HC2; Serum-derived hyaluronan-associated protein; SHAP