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Human MMP-11 Antibody

Catalog #: MAB3657
1 Citation 4 Reviews Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB3657
MAB3657-SP
Product Details
Citations (1)
FAQs
Supplemental Products
Reviews (4)
Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human MMP-11 Antibody Summary

Species Reactivity
Human
Specificity
Detects human MMP-11 in direct ELISAs.
Source
Monoclonal Mouse IgG2B Clone # 135421
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
E. coli-derived recombinant human MMP‑11
Met1-Leu488
Accession # P24347
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 
Intracellular Staining by Flow Cytometry
2.5 µg/106 cells
HepG2 human hepatocellular carcinoma cell line fixed with paraformaldehyde and permeabilized with saponin

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: MMP-11

MMP-11, also called Stromelysin-3, is a metalloproteinase secreted by cells of mesenchymal origin. Human MMP-11 contains a 31 amino acid (aa) signal sequence, a 65 aa propeptide cleaved at a furin consensus sequence, and a 390 aa mature sequence with zinc metalloproteinase and hemopexin-like domains. The human 45 kDa mature MMP-11 shows 89% aa identity with mouse. An inducible low-abundance 40 kDa isoform is a constitutively active intracellular form. MMP-11 is upregulated in stromal cells near many invasive carcinomas, where it can cleave IGFBP, allowing IGF-1 to promote tumor cell growth.

Long Name
Matrix Metalloproteinase 11
Entrez Gene IDs
4320 (Human)
Alternate Names
EC 3.4.24; EC 3.4.24.-; EC 3.4.24.24; matrix metallopeptidase 11 (stromelysin 3); matrix metalloproteinase 11 (stromelysin 3); Matrix metalloproteinase-11; MMP11; MMP-11; SL-3; ST3; STMY3stromelysin 3; stromelysin III; stromelysin-3

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Citation for Human MMP-11 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Targeting antisense mitochondrial noncoding RNAs induces bladder cancer cell death and inhibition of tumor growth through reduction of survival and invasion factors
    Authors: V Borgna, L Lobos-Gonz, F Guevara, E Landerer, M Bendek, R Ávila, V Silva, C Villota, M Araya, A Rivas, C López, T Socias, J Castillo, L Alarcón, LO Burzio, VA Burzio, J Villegas
    J Cancer, 2020-01-17;11(7):1780-1791.
    Species: Human
    Sample Types: Cell Culture Lysates
    Applications: Western Blot

FAQs

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Reviews for Human MMP-11 Antibody

Average Rating: 4.3 (Based on 4 Reviews)

5 Star
25%
4 Star
75%
3 Star
0%
2 Star
0%
1 Star
0%

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Human MMP-11 Antibody
By Anonymous on 01/14/2021
Application: Microarrays Sample Tested: EDTA Plasma Species: Human
Other Human MMP-11 Antibody MAB3657
Human MMP-11 Antibody
By Anonymous on 02/07/2020
Application: MiAr Sample Tested: EDTA Plasma Species: Human

Antibody was printed on custom arrays and incubated with fluorescently labeled human EDTA plasma

Microarray Human MMP-11 Antibody MAB3657
Human MMP-11 Antibody
By Anonymous on 11/14/2018
Application: Microarrays Sample Tested: EDTA Plasma Species: Human
Human MMP-11 Antibody
By Anonymous on 11/11/2018
Application: ELISA Sample Tested: Serum and Plasma Species: Human