Human Nurr1/NGFI-B beta/NR4A2 MAb (Protein A Purified)

Catalog #: PP-N1404-0C Datasheet / COA / SDS

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PP-N1404-0C

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Human Nurr1/NGFI-B beta/NR4A2 MAb (Protein A Purified) Summary

Species Reactivity

Human

Source

Monoclonal Mouse IgG2a Clone # N1404

Label

Unconjugated

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Applications

Recommended Concentration

Sample

Western Blot

Please refer to the PDF datasheet for specifications.

Immunohistochemistry

Please refer to the PDF datasheet for specifications.

Immunoprecipitation

Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: Nurr1/NGFI-B beta/NR4A2

Nurr1 belongs to the nerve growth factor-induced clone B subfamily of nuclear receptor superfamily and is designated NR4A2 in the Unified Nomenclature System for NRs. Nurr1 can function as a ligand-independent transcription factor. Nurr1 also heterodimerizes with retinoid X receptors (RXRs) to function as ligand-regulated transcription factor. Nurr 1 is important for specification of dopaminergic neurons that degenerate in Parkinsons disease. Human and mouse Nurr1 share 99% amino acid sequence homology.

Long Name

Nur-related Factor 1/Nerve Growth Factor Induced B beta/Nuclear Receptor Subfamily 4, Group A, 2

Entrez Gene IDs

4929 (Human); 18227 (Mouse)

Alternate Names

human homolog of; NGFI-B beta; NOT; NR4A2; nuclear receptor subfamily 4, group A, member 2; Nurr1; orphan nuclear receptor NR4A2; Orphan nuclear receptor NURR1; T-cell nuclear receptor NOT; TINUR; transcriptionally inducible nuclear receptor related 1; Transcriptionally-inducible nuclear receptor