Human TDP-43/TARDBP Antibody Summary
Met1-Thr103
Accession # Q13148
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Applications
This antibody functions as an ELISA capture antibody when paired with Mouse Anti-Human TDP-43/TARDBP Monoclonal Antibody (Catalog # MAB77783).
This product is intended for assay development on various assay platforms requiring antibody pairs.
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: TDP-43/TARDBP
TDP-43 (TAR DNA binding protein of 43 kDa; gene name TARDBP) is a 414 amino acid (aa) nuclear RNA/DNA binding phosphoprotein that regulates transcription and splicing. TDP-43 is aberrantly expressed in most forms of amylotrophic lateral sclerosis and frontotemporal lobar degeneration. In these cases it is absent from the nucleus and accumulates, along with a truncated 20-28 kDa form, in ubiquitin-containing inclusion bodies. TDP-43 can also influence CFTR exon 9 skipping in cystic fibrosis. Within aa 1-103, human and mouse TDP-43 share 100% aa sequence identity, and 99% aa identity with rat TDP-43.
Product Datasheets
Citations for Human TDP-43/TARDBP Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 3
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Development of a Sensitive and Reliable Meso Scale Discovery-Based Electrochemiluminescence Immunoassay to Quantify TDP-43 in Human Biofluids
Authors: An, J;Gopalakrishnan, L;Ortega, V;Saul, J;Kadali, R;Bowser, R;
Biosensors
Species: Human
Sample Types: Serum, Plasma
Applications: Immunodepletion, ELISA Detection -
Location and function of TDP-43 in platelets, alterations in neurodegenerative diseases and arising considerations for current plasma biobank protocols
Authors: Luthi-Carter, R;Cappelli, S;Le Roux-Bourdieu, M;Tentillier, N;Quinn, JP;Petrozziello, T;Gopalakrishnan, L;Sethi, P;Choudhary, H;Bartolini, G;Gebara, E;Stuani, C;Font, L;An, J;Ortega, V;Sage, J;Kosa, E;Trombetta, BA;Simeone, R;Seredenina, T;Afroz, T;Berry, JD;Arnold, SE;Carlyle, BC;Adolfsson, O;Sadri-Vakili, G;Buratti, E;Bowser, R;Agbas, A;
Scientific reports
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: ELISA Detection -
Suberoylanilide hydroxamic acid suppresses axonal damage and neurological dysfunction after subarachnoid hemorrhage via the HDAC1/HSP70/TDP-43 axis
Authors: K Luo, Z Wang, K Zhuang, S Yuan, F Liu, A Liu
Experimental & Molecular Medicine, 2022-05-02;0(0):.
Species: Human
Sample Types: CSF
Applications: ELISA Capture
FAQs
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Reconstitution Buffers
Secondary Antibodies
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