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Human TDP-43/TARDBP Antibody

Catalog #: MAB77782
2 Citations Datasheet / COA / SDS
Recombinant Monoclonal Antibody
Catalog # Availability Size / Price Qty
MAB77782-100
MAB77782-SP
Product Details
Citations (2)
FAQs
Supplemental Products
Reviews
Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human TDP-43/TARDBP Antibody Summary

Species Reactivity
Human
Specificity
Detects human TDP-43/TARDBP in direct ELISAs.
Source
Recombinant Monoclonal Mouse IgG2A Clone # 671818R
Purification
Protein A or G purified from cell culture supernatant
Immunogen
E. coli-derived recombinant human/mouse/rat TDP-43/TARDBP
Met1-Thr103
Accession # Q13148
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
ELISA

This antibody functions as an ELISA capture antibody when paired with Mouse Anti-Human TDP-43/TARDBP Monoclonal Antibody (Catalog # MAB77783).

This product is intended for assay development on various assay platforms requiring antibody pairs.

 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: TDP-43/TARDBP

TDP-43 (TAR DNA binding protein of 43 kDa; gene name TARDBP) is a 414 amino acid (aa) nuclear RNA/DNA binding phosphoprotein that regulates transcription and splicing. TDP-43 is aberrantly expressed in most forms of amylotrophic lateral sclerosis and frontotemporal lobar degeneration. In these cases it is absent from the nucleus and accumulates, along with a truncated 20-28 kDa form, in ubiquitin-containing inclusion bodies. TDP-43 can also influence CFTR exon 9 skipping in cystic fibrosis. Within aa 1-103, human and mouse TDP-43 share 100% aa sequence identity, and 99% aa identity with rat TDP-43.

Long Name
TAR DNA-binding Protein 43
Entrez Gene IDs
23435 (Human)
Alternate Names
ALS10; ALS10TAR DNA-binding protein-43; TAR DNA binding protein; TARDBP; TDP43; TDP-43; TDP-43TAR DNA-binding protein 43

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Citations for Human TDP-43/TARDBP Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Location and function of TDP-43 in platelets, alterations in neurodegenerative diseases and arising considerations for current plasma biobank protocols
    Authors: Luthi-Carter, R;Cappelli, S;Le Roux-Bourdieu, M;Tentillier, N;Quinn, JP;Petrozziello, T;Gopalakrishnan, L;Sethi, P;Choudhary, H;Bartolini, G;Gebara, E;Stuani, C;Font, L;An, J;Ortega, V;Sage, J;Kosa, E;Trombetta, BA;Simeone, R;Seredenina, T;Afroz, T;Berry, JD;Arnold, SE;Carlyle, BC;Adolfsson, O;Sadri-Vakili, G;Buratti, E;Bowser, R;Agbas, A;
    Scientific reports
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Detection
  2. Suberoylanilide hydroxamic acid suppresses axonal damage and neurological dysfunction after subarachnoid hemorrhage via the HDAC1/HSP70/TDP-43 axis
    Authors: K Luo, Z Wang, K Zhuang, S Yuan, F Liu, A Liu
    Experimental & Molecular Medicine, 2022-05-02;0(0):.
    Species: Human
    Sample Types: CSF
    Applications: ELISA Capture

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