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Learn MoreMacula Densa Cell Markers
Clicking on a molecule name will take you to our selection of antibodies, proteins, small molecules, immunoassays, and enzymatic assays for that molecule.
Voltage-Activated
Voltage-Activated
Inward Rectifier
Inward Rectifier
Voltage-Gated
Voltage-Gated
Overview
Macula Densa Cells Overview
The macula densa (MD) is a region of tubular epithelium at the transition from the thick ascending loop to the distal convoluted tubule. MD cells are adjacent to both afferent and efferent glomerular arterioles. They provide tubuloglomerular feedback in the juxtaglomerular apparatus (JGA), adjusting arteriolar flow based on the composition of tubular filtrate. MD cells monitor the Na+ concentration in the tubular fluid by means of changes in sodium-driven increases in NCKK2 cotransport. They regulate afferent arteriolar tone and glomerular filtration rate (GFR) in response to both increases and decreases in Na+ concentration.