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C1qTNF1: Products
C1qTNF proteins constitute a highly conserved family of Acrp30/Adiponectin paralogs that share a modular organization comprising an N-terminal signal peptide, a short variable region, a collagenous domain, and a C-terminal globular domain. C1qTNF proteins are predicted to have trimeric structures that assemble into hexameric and higher-order molecular forms. Circulating levels of CTRP1 (C1qTNF1) are elevated in obesity, hypertension, and diabetes but can be decreased in the serum of diet-induced obese mice.
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