MBP: Products
Myelin Basic Protein (MBP) is the most abundant protein component of the myelin membrane in the central nervous system (CNS). Human MBP has 304 amino acids (aa) and shows 71% and 49% aa sequence identity with the mouse and rat orthologs, respectively. Alternative splicing of a single gene, and the optional posttranslational modification of different aa residues, produces a spectrum of isoforms that range in size from 14 kDa to 21.5 kDa. These isoforms exhibit different developmental and cellular expression patterns and may have different specialized functions.
MBP has a role in both the formation and stabilization of the myelin membrane in the CNS. It has also been suggested that MBP is involved in signaling pathways in neural cells and T cells. Research has shown that antibodies against MBP play a role in the development of multiple sclerosis (MS) in a subset of patients. Additionally, elevated levels of MBP in the cerebrospinal fluid are thought to be a sign of myelin breakdown and could serve as a biomarker for several neurodegenerative diseases including MS, traumatic brain injury, and stroke.
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