Aging and Cellular Senescence
Aging is a gradual, irreversible process associated with a progressive loss of tissue and organ functions, chronic, low-grade inflammation, and an increased risk of age-related diseases.1 These changes are in part attributed to an accumulation of senescent cells that have undergone a stress-induced program of permanent cell cycle arrest and display a pro-inflammatory, senescence-associated secretory phenotype (SASP).
While acute cellular senescence during embryonic development and wound healing is beneficial as a short-term process that controls cell growth and tissue organization, chronic senescence that occurs during aging is more...