Human Activin RIIA/B Antibody

Catalog #: MAB3391
2 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB3391
MAB3391-SP

Product Details

Citations (2)

Supplemental Products

Reviews

Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Activin RIIA/B Antibody Summary

Species Reactivity

Human

Specificity

Detects human Activin RII in direct ELISA and Western blots.

Source

Monoclonal Mouse IgG₁ Clone # 60401

Purification

Protein A or G purified from ascites

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Activin RIIB
Ser19-Thr134
Accession # Q13705

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration

Sample

Western Blot

1 µg/mL

Recombinant Human Activin RIIA Fc Chimera (Catalog # 340-R2)
Recombinant Human Activin RIIB Fc Chimera (Catalog # 339-RBB)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Activin RIIA/B

Members of the TGF- beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction. Activin receptor type IIB is a type II receptor that mediates multiple signals for transforming growth factor-beta (TGF-beta) family members, including Activin, Nodal, Bmp7, GDF1, GDF3, Myostatin (GDF8), and GDF11. Through alternative mRNA splicing, multiple ActR-IIB isoforms can also be generated.

Long Name

Activin Receptor IIA/B

Alternate Names

Activin RIIA/B; ACTRII; ACVR2

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citations for Human Activin RIIA/B Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7.
Authors: Sengle G, Ono RN, Lyons KM, Bachinger HP, Sakai LY
J. Mol. Biol., 2008-07-02;381(4):1025-39.
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA Development
Differentiation of Human Induced-Pluripotent Stem Cells into Smooth-Muscle Cells: Two Novel Protocols.
Authors: Yang L, Geng Z, Nickel T, Johnson C, Gao L, Dutton J, Hou C, Zhang J
PLoS ONE, 2016-01-15;11(1):e0147155.