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Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified)

Catalog #: PP-H1415-0C
4 Citations Datasheet / COA / SDS
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PP-H1415-0C
Product Details
Citations (4)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified) Summary

Species Reactivity
Human
Source
Monoclonal Mouse IgG2a Clone # H1415
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
Please refer to the PDF datasheet for specifications.
Immunohistochemistry
Please refer to the PDF datasheet for specifications.
Immunoprecipitation
Please refer to the PDF datasheet for specifications.
Chromatin Immunoprecipitation (ChIP)
Please refer to the PDF datasheet for specifications.
Direct ELISA
Please refer to the PDF datasheet for specifications.
Gel Supershift Assay
Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: HNF-4 alpha/NR2A1

Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha; NR2A1) is a member of the orphan nuclear receptor family. HNF4 alpha is expressed in the liver, kidney, intestine and pancreas. Mutation of HNF4 alpha in humans has been associated with maturity-onset diabetes of the young type 1 (MODY1). HNF4 binds to DNA as an exclusive homodimer. The HNF4 alpha gene is alternatively spliced and may generate up to nine different isoforms, HNF4 alpha 1 through HNF4 alpha 9. The expression of HNF-4 gamma (NR2A2) is observed in the pancreas, kidney, small intestine, and testes with no expression detected in the liver. The level of HNF-4 gamma is less 10% than that of HNF-4 alpha.

Long Name
Hepatocyte Nuclear Factor-4, alpha
Entrez Gene IDs
3172 (Human)
Alternate Names
FLJ39654; hepatic nuclear factor 4 alpha; hepatocyte nuclear factor 4, alpha; hepatocyte nuclear factor 4-alpha; HNF4 alpha; HNF-4 alpha; HNF4A; HNF4a7; HNF-4-alpha; HNF4alpha10/11/12; HNF4HNF4a8; MODY; MODY1; NR2A1; NR2A1HNF4a9; NR2A21; Nuclear receptor subfamily 2 group A member 1; TCF; TCF14; TCF-14; TCF14HNF4alpha; Transcription factor 14; Transcription factor HNF-4; transcription factor-14

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Citations for Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified)

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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  1. HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes
    Authors: Ng, NHJ;Ghosh, S;Bok, CM;Ching, C;Low, BSJ;Chen, JT;Lim, E;Miserendino, MC;Tan, YS;Hoon, S;Teo, AKK;
    Nature communications
    Species: Human
    Sample Types: Cell Lysates, Whole Cells, Chromatin
    Applications: Flow Cytometry, Western Blot, Chromatin Immunoprecipitation (ChIP), Immunocytochemistry
  2. Mechanism of paracrine communications between hepatic progenitor cells and endothelial cells
    Authors: S Lee, R Karns, S Shin
    Cellular Signalling, 2022-08-30;100(0):110458.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  3. Long-term oral administration of an HNF4alpha agonist prevents weight gain and hepatic steatosis by promoting increased mitochondrial mass and function
    Authors: V Veeriah, SH Lee, F Levine
    Cell Death & Disease, 2022-01-27;13(1):89.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  4. Plasmodium vivax liver stage assay platforms using Indian clinical isolates
    Authors: PA Subramani, N Vartak-Sha, S Sreekumar, P Mathur, B Nayer, S Dakhore, SK Basavanna, DM Kalappa, RV Krishnamur, B Mukhi, P Mishra, N Yoshida, SK Ghosh, R Shandil, S Narayanan, B Campo, K Hasegawa, AR Anvikar, N Valecha, V Sundaramur
    Malar. J., 2020-06-22;19(1):214.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC

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