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Mouse IL-6 Antibody

Catalog #: MAB406
96 Citations 5 Reviews Datasheet / COA / SDS
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MAB406-SP
MAB406-100
MAB406-500
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Detection of Recombinant Mouse IL‑6 by Western Blot.
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Citations (96)
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Mouse IL-6 Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse IL-6 in ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) IL‑6, recombinant porcine IL‑6, recombinant rat IL-6, rhIL-11, rhCT-1, or rhCLC is observed.
Source
Monoclonal Rat IgG1 Clone # MP5-20F3
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
COS-7 African green monkey SV40 transformed kidney fibroblast-like cell line-derived recombinant mouse IL-6
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below

Mouse IL-6 Sandwich Immunoassay

Recommended Concentration
Reagent
ELISA Capture (Matched Antibody Pair)
2-8 µg/mL 

Use in combination with:

Detection Reagent: Mouse IL‑6 Biotinylated Antibody (Catalog # BAF406)

Standard: Recombinant Mouse IL-6 Protein (Catalog # 406-ML)

Neutralization
Measured by its ability to neutralize IL‑6-induced proliferation in the T1165.85.2.1 mouse plasmacytoma cell line. Nordan, R.P. et al. (1987) J. Immunol. 139:813. The Neutralization Dose (ND50) is typically 0.005-0.025 µg/mL in the presence of 0.25 ng/mL Recombinant Mouse IL‑6.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Recombinant Mouse IL-6 antibody by Western Blot. View Larger

Detection of Recombinant Mouse IL‑6 by Western Blot. Western blot shows 25 ng of Recombinant Mouse IL-6 (406-ML), Recombinant Human IL-6 (206-IL) and Recombinant Rat IL-6 (506-RL). PVDF Membrane was probed with 1 µg/mL of Rat Anti-Mouse IL-6 Monoclonal Antibody (Catalog # MAB406) followed by HRP-conjugated Anti-Rat IgG Secondary Antibody (HAF005). A specific band was detected for IL-6 at approximately 18 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 3.

Neutralization Cell Proliferation Induced by IL‑6 and Neutralization by Mouse IL‑6 Antibody. View Larger

Cell Proliferation Induced by IL‑6 and Neutralization by Mouse IL‑6 Antibody. Recombinant Mouse IL-6 (406-ML) stimulates proliferation in the T1165.85.2.1 mouse plasmacytoma cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse IL-6 (0.25 ng/mL) is neutralized (green line) by increasing concentrations of Mouse IL-6 Monoclonal Antibody (Catalog # MAB406). The ND50 is typically 0.005-0.025 µg/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IL-6

Interleukin-6 (IL-6) is a pleiotropic, alpha -helical, phosphorylated and variably glycosylated cytokine that plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. Mature mouse IL-6 is 187 amino acids (aa) in length that is typically expressed as a 22-28 kDA molecular weight protein. Mouse IL-6 shares 39% and 85% aa sequence identity with human and rat IL-6, respectively. Alternative splicing generates several isoforms with internal deletions, some of which exhibit antagonistic properties. IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R alpha) and a signal transducing subunit (gp130). IL-6 binds to IL-6 R alpha, triggering IL-6 R alpha association with gp130 and gp130 dimerization. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha. Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 R alpha is predominantly restricted to hepatocytes, monocytes, and resting lymphocytes. Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 R alpha but not from other cytokines that use gp130 as a co-receptor. IL-6, along with TNF-alpha and IL-1, function to drive the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis. IL-6 can also function as an anti-inflammatory molecule, as in skeletal muscle where it is secreted in response to exercise. In addition, it enhances hematopoietic stem cell proliferation and the differentiation of Th17 cells, memory B cells, and plasma cells.

Long Name
Interleukin 6
Entrez Gene IDs
3569 (Human); 16193 (Mouse); 24498 (Rat); 399500 (Porcine); 280826 (Bovine); 403985 (Canine); 102138971 (Cynomolgus Monkey); 100034196 (Equine); 493687 (Feline); 463288 (Primate); 100008733 (Rabbit)
Alternate Names
B-cell differentiation factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CTL differentiation factor ; HSF; hybridoma growth factor; IFNB2; IFN-beta-2; IL6; IL-6; Interferon beta-2; interleukin 6 (interferon, beta 2); interleukin BSF-2; interleukin-6; MGI-2A

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Citations for Mouse IL-6 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

96 Citations: Showing 1 - 10
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  1. PDE11A negatively regulates lithium responsivity
    Mol Psychiatry, 2016-09-20;0(0):.
  2. Delayed Neutralization of Interleukin 6 Reduces Organ Injury, Selectively Suppresses Inflammatory Mediator, and Partially Normalizes Immune Dysfunction Following Trauma and Hemorrhagic Shock
    Authors: Yong Zhang, Jinxiang Zhang, Sebastian Korff, Faez Ayoob, Yoram Vodovotz, Timothy R. Billiar
    Shock
  3. Microglia-induced IL-6 protects against neuronal loss following HSV-1 infection of neural progenitor cells
    Authors: Ana J. Chucair-Elliott, Christopher Conrady, Min Zheng, Chandra M. Kroll, Thomas E. Lane, Daniel J. J. Carr
    Glia
  4. Class A Scavenger Receptor Exacerbates Osteoclastogenesis by an Interleukin-6-Mediated Mechanism through ERK and JNK Signaling Pathways
    Authors: Shuyu Guo, Yuanyuan Ni, Jingjing Ben, Yang Xia, Tingting Zhou, Dongyue Wang et al.
    International Journal of Biological Sciences
  5. Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling
    Authors: Lomeli R. Carpio, Elizabeth W. Bradley, Meghan E. McGee-Lawrence, Megan M. Weivoda, Daniel D. Poston, Amel Dudakovic et al.
    Science Signaling
  6. Macrophages potentiate STAT3 signaling in skeletal muscles and regulate pancreatic cancer cachexia
    Authors: Surendra K. Shukla, Spas D. Markov, Kuldeep S. Attri, Enza Vernucci, Ryan J. King, Aneesha Dasgupta et al.
    Cancer Letters
  7. A Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Model of Non-metastatic Breast Cancer
    Authors: Jeremy C. Borniger, William H. Walker II, Surbhi, Kathryn M. Emmer, Ning Zhang, Abigail A. Zalenski et al.
    Cell Metabolism
  8. Delayed activation of PPAR-beta /δ improves long-term survival in mouse sepsis: effects on organ inflammation and coagulation
    Authors: Daniel Busch, Amar Kapoor, Pia Rademann, Frank Hildebrand, Soheyl Bahrami, Christoph Thiemermann et al.
    Innate Immunity
  9. Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis
    Authors: L Zhu, X Cheng, J Shi, J Lin, G Chen, H Jin, AB Liu, H Pyo, J Ye, Y Zhu, H Wang, H Chen, J Fang, L Cai, TC Wang, CS Yang, SP Tu
    Oncogene, 2016-04-25;0(0):.
  10. Intercellular mitochondrial transfer alleviates pyroptosis in dental pulp damage
    Authors: Konghuai Wang, Lu Zhou, Hanqing Mao, Jiayi Liu, Zhi Chen, Lu Zhang
    Cell Proliferation
  11. Role of high-mobility group box-1 in myocardial ischemia/reperfusion injury and the effect of ethyl pyruvate
    Authors: YUNLING LIN, LIANGLONG CHEN, WEIWEI LI, JUN FANG
    Experimental and Therapeutic Medicine
  12. Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling
    Authors: Luan D, Dadpey B, Zaid J et al.
    Diabetes
  13. Stress systems exacerbate the inflammatory response after corneal abrasion in sleep-deprived mice via the IL-17 signaling pathway
    Authors: Xue, Y;Xu, P;Hu, Y;Liu, S;Yan, R;Liu, S;Li, Y;Liu, J;Fu, T;Li, Z;
    Mucosal immunology
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo assay
  14. Nanoparticles of Lactiplantibacillus plantarum K8 Reduce Staphylococcus aureus Respiratory Infection and Tumor Necrosis Factor Alpha- and Interferon Gamma-Induced Lung Inflammation
    Authors: Hong, J;Son, M;Sin, J;Kim, H;Chung, DK;
    Nutrients
    Species: Mouse
    Sample Types: Serum
    Applications: ELISA Capture
  15. CD1d-dependent natural killer T-cells inactivation aggravates sepsis-induced myocardial injury via T lymphocytes infiltration and IL-6 production in mice
    Authors: Chen, LR;Hui-Yang, ;Lu-Liu, ;Wang, XX;Zhang, XM;Wang, HX;
    International immunopharmacology
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  16. The fetal response to maternal inflammation is dependent upon maternal IL-6 in a murine model
    Authors: Bermick, J;Watson, S;Lueschow, S;McElroy, SJ;
    Cytokine
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  17. Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity
    Authors: J Liu, Y Cheng, X Zhang, Y Chen, H Zhu, K Chen, S Liu, Z Li, X Cao
    Cell Reports, 2023-01-18;42(1):111991.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  18. IL6 supports long-term expansion of hepatocytes in vitro
    Authors: R Guo, M Jiang, G Wang, B Li, X Jia, Y Ai, S Chen, P Tang, A Liu, Q Yuan, X Xie
    Nature Communications, 2022-11-29;13(1):7345.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  19. Single-cell transcriptomics reveals a senescence-associated IL-6/CCR6 axis driving radiodermatitis
    Authors: M Paldor, O Levkovitch, D Eidelshtei, R Adar, CD Enk, Y Marmary, S Elgavish, Y Nevo, H Benyamini, I Plaschkes, S Klein, A Mali, S Rose-John, A Peled, E Galun, JH Axelrod
    Oncogene, 2022-07-04;0(0):e15653.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  20. Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling
    Authors: B Czaya, K Heitman, I Campos, C Yanucil, D Kentrup, D Westbrook, O Gutierrez, JL Babitt, G Jung, IB Salusky, M Hanudel, C Faul
    Elife, 2022-03-18;11(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  21. Irradiated fibroblasts increase interleukin-6 expression and induce migration of head and neck squamous cell carcinoma
    Authors: S Suzuki, S Toyoma, Y Kawasaki, T Yamada
    PLoS ONE, 2022-01-28;17(1):e0262549.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  22. M1 macrophages impair tight junctions between endothelial cells after spinal cord injury
    Authors: Y Luo, F Yao, X Hu, Y Li, Y Chen, Z Li, Z Zhu, S Yu, D Tian, L Cheng, M Zheng, J Jing
    Brain research bulletin, 2022-01-04;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  23. Aging triggers an upregulation of a multitude of cytokines in the male and especially the female rodent hippocampus but more discrete changes in other brain regions
    Authors: L Porcher, S Bruckmeier, SD Burbano, JE Finnell, N Gorny, J Klett, SK Wood, MP Kelly
    Journal of Neuroinflammation, 2021-09-22;18(1):219.
    Species: Mouse, Rat
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  24. Transgenic inhibition of interleukin-6 trans-signaling does not prevent skeletal pathologies in mucolipidosis type II mice
    Authors: LM Westermann, A Baranowsky, G Di Lorenzo, T Danyukova, J Soul, JM Schwartz, G Hendrickx, M Amling, S Rose-John, C Garbers, T Schinke, S Pohl
    Scientific Reports, 2021-02-11;11(1):3556.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  25. Macrophage and adipocyte interaction as a source of inflammation in kidney disease
    Authors: C Martos-Rus, G Katz-Green, Z Lin, E Serrano, D Whitaker-M, M Domingo-Vi, M Roche, K Ramaswamy, DC Hooper, B Falkner, MP Martinez C
    Scientific Reports, 2021-02-03;11(1):2974.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  26. Aging Impairs Mitochondrial Function and Mitophagy and Elevates Interleukin 6 Within the Cerebral Vasculature
    Authors: DJ Tyrrell, MG Blin, J Song, SC Wood, DR Goldstein
    J Am Heart Assoc, 2020-11-23;9(23):e017820.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Isotype Control
  27. &beta2-Adrenergic Receptors Increase Cardiac Fibroblast Proliferation Through the G&alphas/ERK1/2-Dependent Secretion of Interleukin-6
    Authors: MA Tanner, TP Thomas, CA Maitz, LA Grisanti
    Int J Mol Sci, 2020-11-12;21(22):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  28. p38&alpha in Macrophages Aggravates Arterial Endothelium Injury by Releasing IL-6 through phosphorylating Megakaryocytic Leukemia 1
    Authors: M Zhang, J Gao, X Zhao, M Zhao, D Ma, X Zhang, D Tian, B Pan, X Yan, J Wu, X Meng, H Yin, L Zheng
    Redox Biology, 2020-11-01;38(0):101775.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  29. Linking skeletal muscle aging with osteoporosis by lamin A/C deficiency
    Authors: L Xiong, K Zhao, Y Cao, HH Guo, JX Pan, X Yang, X Ren, L Mei, WC Xiong
    PLoS Biol., 2020-06-01;18(6):e3000731.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC, Western Blot
  30. Adipocytes promote tumor progression and induce PD-L1 expression via TNF-&alpha/IL-6 signaling
    Authors: Z Li, C Zhang, JX Du, J Zhao, MT Shi, MW Jin, H Liu
    Cancer Cell Int., 2020-05-20;20(0):179.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  31. Inhibition of Serine Protease Activity Protects Against High Fat Diet-Induced Inflammation and Insulin Resistance
    Authors: CS Kuo, JS Chen, LY Lin, GW Schmid-Sch, S Chien, PH Huang, JW Chen, SJ Lin
    Sci Rep, 2020-02-03;10(1):1725.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  32. Endothelial autophagy deficiency induces IL6 - dependent endothelial mesenchymal transition and organ fibrosis
    Authors: Y Takagaki, SM Lee, Z Dongqing, M Kitada, K Kanasaki, D Koya
    Autophagy, 2020-01-22;0(0):1-10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  33. B cell hyperactivation in an Ackr4-deficient mouse strain is not caused by lack of ACKR4 expression
    Authors: N Eckert, K Werth, S Willenzon, L Tan, R Förster
    J. Leukoc. Biol., 2019-12-16;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  34. Berberine ameliorates lipopolysaccharide?induced inflammatory responses in mouse inner medullary collecting duct?3 cells by downregulation of NF?kappaB pathway
    Authors: DG Kim, JW Choi, IJ Jo, MJ Kim, HS Lee, SH Hong, HJ Song, GS Bae, SJ Park
    Mol Med Rep, 2019-11-19;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  35. Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure
    Authors: GT Gardner, JG Travers, J Qian, GS Liu, K Haghighi, N Robbins, M Jiang, Y Li, GC Fan, J Rubinstein, BC Blaxall, EG Kranias
    JACC Basic Transl Sci, 2019-04-29;4(2):188-199.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  36. Regulation of the bi-directional cross-talk between ovarian cancer cells and adipocytes by SPARC
    Authors: B John, C Naczki, C Patel, A Ghoneum, S Qasem, Z Salih, N Said
    Oncogene, 2019-02-14;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  37. Direct Conversion of Mouse Fibroblasts into Neural Stem Cells by Chemical Cocktail Requires Stepwise Activation of Growth Factors and Nup210
    Authors: Y Tang, S Xiong, P Yu, F Liu, L Cheng
    Cell Rep, 2018-07-31;24(5):1355-1362.e3.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Theophylline suppresses interleukin-6 expression by inhibiting glucocorticoid receptor signaling in pre-adipocytes
    Authors: T Mitani, T Takaya, N Harada, S Katayama, R Yamaji, S Nakamura, H Ashida
    Arch. Biochem. Biophys., 2018-04-04;646(0):98-106.
    Species: Mouse
    Sample Types: Plasma
    Applications: ELISA Capture
  39. Transcription factor 21 (Tcf21) promotes proinflammatory interleukin 6 expression and extracellular matrix remodeling in visceral adipose stem cells
    Authors: T Akama, TH Chun
    J. Biol. Chem., 2018-03-14;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Functional Assay, ICC
  40. Tumor-extrinsic discoidin domain receptor 1 promotes mammary tumor growth by regulatingadipose stromal interleukin 6 production in mice
    Authors: X Sun, K Gupta, B Wu, D Zhang, B Yuan, X Zhang, HC Chiang, C Zhang, TJ Curiel, MP Bendeck, S Hursting, Y Hu, R Li
    J. Biol. Chem., 2018-01-03;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. The calcineurin-NFAT axis contributes to host defense during Pseudomonas aeruginosa lung infection
    Authors: Z Pang, RD Junkins, AJ MacNeil, C McCormick, Z Cheng, WM Chen, TJ Lin
    J. Leukoc. Biol., 2017-10-10;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: ELISA Development (Capture)
  42. IL-33 Attenuates Sepsis by Inhibiting IL-17 Receptor Signaling through Upregulation of SOCS3
    Authors: R Lv, J Zhao, M Lei, D Xiao, Y Yu, J Xie
    Cell. Physiol. Biochem., 2017-08-09;42(5):1961-1972.
    Species: Mouse
    Sample Types: Serum
    Applications: ELISA Development (Capture)
  43. Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by Regulating Aldh1a2 Expression
    Authors: TS Zaman, H Arimochi, S Maruyama, C Ishifune, SI Tsukumo, A Kitamura, K Yasutomo
    J. Immunol., 2017-08-04;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6
    Authors: SI Ohkura, S Usui, SI Takashima, N Takuwa, K Yoshioka, Y Okamoto, Y Inagaki, N Sugimoto, T Kitano, M Takamura, T Wada, S Kaneko, Y Takuwa
    PLoS ONE, 2017-08-03;12(8):e0182329.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  45. Inhibitory effect ofquercetinon titaniumparticle-inducedendoplasmic reticulum stress (ERS)-related apoptosisandin vivoosteolysis
    Authors: L Zhang, Z Tian, W Li, X Wang, Z Man, S Sun
    Biosci. Rep., 2017-07-31;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development (Capture)
  46. The human amniotic fluid stem cell secretome effectively counteracts doxorubicin-induced cardiotoxicity
    Sci Rep, 2016-07-21;6(0):29994.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  47. Enhanced immunoregulation of mesenchymal stem cells by IL-10-producing type 1 regulatory T cells in collagen-induced arthritis
    Authors: Jung-Yeon Lim
    Sci Rep, 2016-06-01;6(0):26851.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development (Capture)
  48. IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras-Mutant Lung Cancer
    Authors: MS Caetano, H Zhang, AM Cumpian, L Gong, N Unver, EJ Ostrin, S Daliri, SH Chang, CE Ochoa, S Hanash, C Behrens, II Wistuba, C Sternberg, H Kadara, CG Ferreira, SS Watowich, SJ Moghaddam
    Cancer Res., 2016-04-01;76(11):3189-99.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo, Neutralization
  49. Radiation-driven lipid accumulation and dendritic cell dysfunction in cancer.
    Authors: Gao F, Liu C, Guo J, Sun W, Xian L, Bai D, Liu H, Cheng Y, Li B, Cui J, Zhang C, Cai J
    Sci Rep, 2015-04-29;5(0):9613.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment.
    Authors: Li P, Shan J, Chen X, Zhang D, Su L, Huang X, Yu B, Zhi Q, Li C, Wang Y, Tomei S, Cai Q, Ji J, Li J, Chouchane L, Yu Y, Sun F, Xu Z, Liu B, Zhu Z
    Cell Res, 2015-04-28;25(5):588-603.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Blocking
  51. KIM-1-mediated phagocytosis reduces acute injury to the kidney.
    Authors: Yang L, Brooks C, Xiao S, Sabbisetti V, Yeung M, Hsiao L, Ichimura T, Kuchroo V, Bonventre J
    J Clin Invest, 2015-03-09;125(4):1620-36.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: ELISA Development (Capture)
  52. Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration.
    Authors: Levy O, Calippe B, Lavalette S, Hu S, Raoul W, Dominguez E, Housset M, Paques M, Sahel J, Bemelmans A, Combadiere C, Guillonneau X, Sennlaub F
    EMBO Mol Med, 2015-02-01;7(2):211-26.
    Species: Human, Mouse
    Sample Types: Whole Organism, Whole Tissue
    Applications: IHC, In Vivo
  53. Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling.
    Authors: Chandler, Ronald L, Damrauer, Jeffrey, Raab, Jesse R, Schisler, Jonathan, Wilkerson, Matthew, Didion, John P, Starmer, Joshua, Serber, Daniel, Yee, Della, Xiong, Jessie, Darr, David B, Pardo-Manuel de Villena, Fernando, Kim, William, Magnuson, Terry
    Nat Commun, 2015-01-27;6(0):6118.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  54. Oxidative stress-induced inhibition of Sirt1 by caveolin-1 promotes p53-dependent premature senescence and stimulates the secretion of interleukin 6 (IL-6).
    Authors: Volonte D, Zou H, Bartholomew J, Liu Z, Morel P, Galbiati F
    J Biol Chem, 2014-12-15;290(7):4202-14.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  55. Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis.
    Authors: Bonapace L, Coissieux M, Wyckoff J, Mertz K, Varga Z, Junt T, Bentires-Alj M
    Nature, 2014-10-22;515(7525):130-3.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  56. Autocrine interleukin-6 drives skin-derived mesenchymal stem cell trafficking via regulating voltage-gated Ca(2+) channels.
    Authors: Ke F, Zhang L, Liu Z, Liu J, Yan S, Xu Z, Bai J, Zhu H, Lou F, Wang H, Shi Y, Jiang Y, Su B, Wang H
    Stem Cells, 2014-10-01;32(10):2799-810.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC-P
  57. Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-alpha, and IL-1beta.
    Authors: Zhao Y, Xiao X, Frank S, Lin H, Xia Y
    Am J Physiol Endocrinol Metab, 2014-06-03;307(2):E186-98.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  58. Stabilization and augmentation of circulating AIM in mice by synthesized IgM-Fc.
    Authors: Kai, Toshihir, Yamazaki, Tomoko, Arai, Satoko, Miyazaki, Toru
    PLoS ONE, 2014-05-07;9(5):e97037.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  59. Blockade of Fas signaling in breast cancer cells suppresses tumor growth and metastasis via disruption of Fas signaling-initiated cancer-related inflammation.
    Authors: Liu Q, Tan Q, Zheng Y, Chen K, Qian C, Li N, Wang Q, Cao X
    J Biol Chem, 2014-03-13;289(16):11522-35.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  60. Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity.
    Authors: Ramkhelawon B, Hennessy E, Menager M, Ray T, Sheedy F, Hutchison S, Wanschel A, Oldebeken S, Geoffrion M, Spiro W, Miller G, McPherson R, Rayner K, Moore K
    Nat Med, 2014-03-02;20(4):377-84.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Microarray analyses demonstrate the involvement of type I interferons in psoriasiform pathology development in D6-deficient mice.
    Authors: Baldwin H, Pallas K, King V, Jamieson T, McKimmie C, Nibbs R, Carballido J, Jaritz M, Rot A, Graham G
    J Biol Chem, 2013-11-05;288(51):36473-83.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  62. Catecholamine stress alters neutrophil trafficking and impairs wound healing by beta2-adrenergic receptor-mediated upregulation of IL-6.
    Authors: Kim M, Gorouhi F, Ramirez S, Granick J, Byrne B, Soulika A, Simon S, Isseroff R
    J Invest Dermatol, 2013-10-11;134(3):809-17.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  63. Basophils control T-cell responses and limit disease activity in experimental murine colitis.
    Authors: Gomez M, Talke Y, Hofmann C, Ketelsen I, Hermann F, Reich B, Goebel N, Schmidbauer K, Dunger N, Bruhl H, Renner K, Syed S, Mack M
    Mucosal Immunol, 2013-06-12;7(1):188-99.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  64. Maternal immune activation during gestation interacts with Disc1 point mutation to exacerbate schizophrenia-related behaviors in mice.
    Authors: Lipina T, Zai C, Hlousek D, Roder J, Wong A
    J Neurosci, 2013-05-01;33(18):7654-66.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  65. Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections.
    Authors: Junkins R, MacNeil A, Wu Z, McCormick C, Lin T
    J Immunol, 2013-04-15;190(10):5178-86.
    Species: Mouse
    Sample Types: BALF
    Applications: ELISA Development (Capture)
  66. Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation.
    Authors: Mills, Lisa D, Zhang, Yaqing, Marler, Ronald J, Herreros-Villanueva, Marta, Zhang, Lizhi, Almada, Luciana, Couch, Fergus, Wetmore, Cynthia, Pasca di Magliano, Marina, Fernandez-Zapico, Martin E
    J Biol Chem, 2013-03-12;288(17):11786-94.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Neutralization
  67. Response patterns of cytokines/chemokines in two murine strains after irradiation.
    Authors: Zhang M, Yin L, Zhang K, Sun W, Yang S, Zhang B, Salzman P, Wang W, Liu C, Vidyasagar S, Zhang L, Ju S, Okunieff P, Zhang L
    Cytokine, 2012-01-25;58(2):169-77.
    Species: Mouse
    Sample Types: Plasma
    Applications: Luminex Development
  68. CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis.
    Authors: Roy M, Richard JF, Dumas A, Vallieres L
    J Neuroinflammation, 2012-01-23;9(0):18.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  69. Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatus.
    Authors: Gessner MA, Werner JL, Lilly LM, Nelson MP, Metz AE, Dunaway CW, Chan YR, Ouyang W, Brown GD, Weaver CT, Steele C
    Infect. Immun., 2011-10-28;80(1):410-7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  70. Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy.
    Authors: Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, Boucontet L, Apetoh L, Ghiringhelli F, Casares N, Lasarte JJ, Matsuzaki G, Ikuta K, Ryffel B, Benlagha K, Tesniere A, Ibrahim N, Dechanet-Merville J, Chaput N, Smyth MJ, Kroemer G, Zitvogel L
    J. Exp. Med., 2011-03-07;208(3):491-503.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  71. Resistance of human alveolar macrophages to Bacillus anthracis lethal toxin.
    Authors: Wu W, Mehta H, Chakrabarty K, Booth JL, Duggan ES, Patel KB, Ballard JD, Coggeshall KM, Metcalf JP
    J. Immunol., 2009-10-07;183(9):5799-806.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  72. Stratification is the key: inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis.
    Authors: Osuchowski MF, Connett J, Welch K, Granger J, Remick DG
    Crit. Care Med., 2009-05-01;37(5):1567-73.
    Species: Mouse
    Sample Types: Plasma
    Applications: ELISA Development
  73. ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis.
    Authors: Wieland CW, van der Windt GJ, Florquin S, McKenzie AN, van der Poll T
    Microbes Infect., 2009-03-13;11(4):524-30.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  74. CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis.
    Authors: Wieland CW, van der Windt GJ, Wiersinga WJ, Florquin S, van der Poll T
    Immunology, 2008-04-03;125(2):272-9.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: ELISA Development
  75. Tumor-specific Th17-polarized cells eradicate large established melanoma.
    Authors: Muranski P, Boni A, Antony PA, Cassard L, Irvine KR, Kaiser A, Paulos CM, Palmer DC, Touloukian CE, Ptak K, Gattinoni L, Wrzesinski C, Hinrichs CS, Kerstann KW, Feigenbaum L, Chan CC, Restifo NP
    Blood, 2008-03-19;112(2):362-73.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  76. Maternal immune activation alters fetal brain development through interleukin-6.
    Authors: Smith SE, Li J, Garbett K, Mirnics K, Patterson PH
    J. Neurosci., 2007-10-03;27(40):10695-702.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  77. Comparison of the roles of IL-1, IL-6, and TNFalpha in cell culture and murine models of aseptic loosening.
    Authors: Taki N, Tatro JM, Lowe R, Goldberg VM, Greenfield EM
    Bone, 2006-12-21;40(5):1276-83.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  78. A new RXR agonist, HX630, suppresses intimal hyperplasia in a mouse blood flow cessation model.
    Authors: Haraguchi G, Suzuki J, Kosuge H, Ogawa M, Koga N, Muto S, Itai A, Kagechika H, Shudo K, Isobe M
    J. Mol. Cell. Cardiol., 2006-09-11;41(5):885-92.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  79. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality.
    Authors: Osuchowski MF, Welch K, Siddiqui J, Remick DG
    J. Immunol., 2006-08-01;177(3):1967-74.
    Species: Mouse
    Sample Types: Plasma
    Applications: ELISA Development
  80. Glechoma hederacea inhibits inflammatory mediator release in IFN-gamma and LPS-stimulated mouse peritoneal macrophages.
    Authors: An HJ, Jeong HJ, Um JY, Kim HM, Hong SH
    J Ethnopharmacol, 2006-03-10;106(3):418-24.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  81. Role of interleukin-6 in cardiomyocyte/cardiac fibroblast interactions during myocyte hypertrophy and fibroblast proliferation.
    Authors: Fredj S, Bescond J, Louault C, Delwail A, Potreau D
    J. Cell. Physiol., 2005-08-01;204(2):428-36.
    Species: Mouse
    Sample Types: Cell Culture Supernates, Whole Cells
    Applications: ELISA Development, Neutralization
  82. Sequential ELISA to profile multiple cytokines from small volumes.
    Authors: Osuchowski MF, Siddiqui J, Copeland S, Remick DG
    J. Immunol. Methods, 2005-07-01;302(1):172-81.
    Species: Mouse
    Sample Types: Plasma
    Applications: ELISA Development
  83. Selective macrophage suppression during sepsis.
    Authors: Ellaban E, Bolgos G, Remick D
    Cell. Immunol., 2005-02-26;231(1):103-11.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  84. Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways.
    Authors: Miyamoto M, Prause O, Sjostrand M, Laan M, Lotvall J, Linden A
    J. Immunol., 2003-05-01;170(9):4665-72.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  85. Tick salivary gland extract-activated transmission of Borrelia afzelii spirochaetes.
    Authors: Pechova J, Stĕpánová G, Kovar L, Kopecky J
    Folia Parasitol., 2002-01-01;49(2):153-9.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  86. Fli1-haploinsufficient dermal fibroblasts promote skin-localized transdifferentiation of Th2-like regulatory T cells
    Authors: R Saigusa, Y Asano, T Taniguchi, M Hirabayash, K Nakamura, S Miura, T Yamashita, T Takahashi, Y Ichimura, T Toyama, A Yoshizaki, M Trojanowsk, S Sato
    Arthritis Res. Ther., 2018-02-07;20(1):23.
  87. Melatonin induces anti-inflammatory effects via endoplasmic reticulum stress in RAW264.7 macrophages
    Authors: Yina Chen, Qian Zhao, Yangjie Sun, Yin Jin, Jie Zhang, Jiansheng Wu
    Molecular Medicine Reports
  88. IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma.
    Authors: Giulia Biffi, Tobiloba E. Oni, Benjamin Spielman, Yuan Hao, Ela Elyada, Youngkyu Park et al.
    Cancer Discovery
  89. Interleukin-6 Is Essential for Primary Resistance to Francisella tularensis Live Vaccine Strain Infection
    Authors: Sherry L. Kurtz, Oded Foreman, Catharine M. Bosio, Miriam R. Anver, Karen L. Elkins
    Infection and Immunity
  90. Interleukin-6 enhances glucose-stimulated insulin secretion from pancreatic beta-cells: potential involvement of the PLC-IP3-dependent pathway
    Authors: Toshinobu Suzuki, Junta Imai, Tetsuya Yamada, Yasushi Ishigaki, Keizo Kaneko, Kenji Uno et al.
    Diabetes
  91. A microwell-based impedance sensor on an insertable microneedle for real-time in vivo cytokine detection
    Authors: Naixin Song, Pengfei Xie, Wen Shen, Hanju Oh, Yejia Zhang, Flavia Vitale et al.
    Microsystems & Nanoengineering
  92. Spinal interleukin-6 contributes to central sensitisation and persistent pain hypersensitivity in a model of juvenile idiopathic arthritis
    Authors: Charlie H.T. Kwok, Annastazia E Learoyd, Julia Canet-Pons, Tuan Trang, Maria Fitzgerald
    Brain, Behavior, and Immunity
  93. Activation of JAK/STAT Signaling in Megakaryocytes Sustains Myeloproliferation In Vivo
    Authors: Brittany Woods, Wei Chen, Sophia Chiu, Christian Marinaccio, Chunling Fu, Lilly Gu et al.
    Clinical Cancer Research
  94. Fisetin inhibits pristine-induced systemic lupus erythematosus in a murine model through CXCLs regulation
    Authors: Su‑Ping Xu, Yong‑Sheng Li
    International Journal of Molecular Medicine
  95. The role of IL-6 in neurodevelopment after prenatal stress
    Authors: Serena B. Gumusoglu, Rebecca S. Fine, Samuel J. Murray, Jada L. Bittle, Hanna E. Stevens
    Brain, Behavior, and Immunity
  96. Considerations regarding use of solvents in in vitro cell based assays
    Authors: Michael Timm, Lasse Saaby, Lise Moesby, Erik Wind Hansen
    Cytotechnology

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Mouse IL-6 Antibody
By Anonymous on 08/12/2021
Application: WB Sample Tested: Heart tissue Species: Mouse
Western Blot Mouse IL-6 Antibody MAB406
Mouse IL-6 Antibody
By Anonymous on 02/10/2021
Application: WB Sample Tested: Ear tissue,Heart tissue Species: Mouse
Western Blot Mouse IL-6 Antibody MAB406
Mouse IL‑6 Antibody
By Anonymous on 04/11/2019
Application: Cell Invasion Sample Tested: Cancer-associated Fibroblasts,tumor cells Species: Mouse
Other Mouse IL‑6 Antibody MAB406
Mouse IL‑6 Antibody
By Anonymous on 05/11/2018
Application: Cell Depl Sample Tested: Pancreatic cancer cells Species: Mouse
Mouse IL-6 Antibody
By Anonymous on 12/08/2017
Application: ELISA Sample Tested: Human recombinant antibody Species: Mouse
ELISA Mouse IL-6 Antibody MAB406