Active Degraders: Products

Degraders are a way to knock down target proteins within cells. They are made up of binding moieties for an E3 ubiquitin ligase and a target protein joined by a linker. These hybrid molecules induce selective, proteasome-dependent degradation of target proteins.

"Active Degraders" has 90 results in Products.
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MS 154 

Potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant EGFR

MS 39 

Potent and selective VHL-recruiting Degrader (PROTAC®) of mutant EGFR

CG 428 

Potent tropomyosin receptor kinase (TRK) Degrader

CG 858 

Selective BRAF-V600E protein Degrader (uSMITE™)

SIM1 

Potent and selective trivalent BET Bromodomain Degrader (PROTAC®)

SJF 0628 

Potent BRAF Degrader (PROTAC®

SJF 0661 

Negative control for SJF 0628 (Cat. No. 7463)

BSJ-4-116 

Selective CDK12 PROTAC® Degrader

SK 575 

Potent PARP1 Degrader (PROTAC®)

PT-65 

Potent GSK3 Degrader (PROTAC®)

SJ 1008030 

Selective JAK2 Degrader (PROTAC®)

(+)-JQ1 maleimide 

JQ1-maleimide functionalized probe; induces proteasomal degradation of BRD4

AUTAC4 

Mitochondrial targeting AUTAC Degrader

SJ 11646 

Potent and selective LCK Degrader (PROTAC®)

SJ 10542 

Potent and selective JAK2/3 Degrader (PROTAC®)

CST 905 

Potent and selective BRAFV600E Degrader (PROTAC®)

CPS2 

Potent and selective CDK2 Degrader (PROTAC®)

CST 967 

Potent and selective USP7 Degrader (PROTAC®)

LL-K9-3 

Selective HyT-based degrader of the CDK9-cyclin T1 complex

UNC 6852 

Polycomb repressive complex 2 (PRC2) Degrader (PROTAC®)

GSK 215 

Potent and selective focal adhesion kinase (FAK) Degrader (PROTAC®)

HHP 9 

BET bromodomain Degrader (PROTAC®); also potent Hedgehog pathway inhibitor

JB 300 

Aurora A Degrader (PROTAC®)

NAMPT PROTAC® A7 

Potent and selective nicotinamide phosphoribosyl transferase (NAMPT) Degrader (PROTAC®)

HDAC4 CHDI Degrader 11 

Potent and selective HDAC4 Degrader (PROTAC®)

HER2 PROTAC® CH7C4 

Potent and selective HER2 targeting Degrader (PROTAC®)

5-Ph-IAA-AM 

Selective and potent TAG Degrader for auxin-inducible degron 2 system; 5-Ph-IAA analog

IRAK3 Degrader 23 

IRAK3 Degrader (PROTAC®

PROTAC®(H-PGDS)-7 

Potent hematopoietic prostaglandin D2 synthase Degrader (PROTAC®)

CST 626 

Potent pan IAP Degrader (PROTAC®)

JNJ 1013 

Interleukin 1 Receptor Associated Kinase 1 (IRAK1) Degrader (PROTAC®)

α-Synuclein Degrader 2b 

α-synuclein Degrader (PROTAC®)

STING Degrader SP23 

Selective STING Degrader (PROTAC®)

MS 28 

Cyclin D1, CDK4/6 and cyclin D3 Degrader (PROTAC®)

MS 147 

PRC1 Degrader (PROTAC®); degrades BMI1 and RING1B

MS 159 

NSD2 Degrader (PROTAC®)

JPS016 

Selective class I HDAC Degrader (PROTAC®)

JPS036 

Selective HDAC3 Degrader (PROTAC®)

UNC 8732 

Potent NSD2 Degrader

JQ dS-4 

BRG1/SMARCA4 Degrader (PROTAC®)
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