Human C1qR1/CD93 Antibody

Catalog #: AF2379
5 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
AF2379-SP	In Stock	25 ug / $149
AF2379	In Stock	100 ug / $489

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All C1qR1/CD93 Antibodies

Product Details

Citations (5)

Supplemental Products

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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human C1qR1/CD93 Antibody Summary

Species Reactivity

Human

Specificity

Detects human C1q R1/CD93 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant mouse C1q R1 is observed.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant human C1q R1/CD93
Ala24-Lys580
Accession # Q9NPY3

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Western Blot

0.1 µg/mL

Recombinant Human C1q R1/CD93

Flow Cytometry

2.5 µg/10⁶ cells

Human whole blood monocytes

CyTOF-ready

Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Immunocytochemistry

5-15 µg/mL

Immersion fixed U937 human histiocytic lymphoma cell line

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunocytochemistry

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C1qR1/CD93 in U937 Human Cell Line. C1qR1/CD93 was detected in immersion fixed U937 human histiocytic lymphoma cell line using Goat Anti-Human C1qR1/CD93 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2379) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; NL001) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. Staining was performed using our protocol for Fluorescent ICC Staining of Non-adherent Cells.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Reconstitution Buffer Available

Reconstitution Buffer 1 (PBS)

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: C1qR1/CD93

C1q R1, also known as CD93, C1q R, and C1q RP, is a single chain glycoprotein expressed on cells of myeloid origin, endothelial cells, and hematopoietic progenitor cells. In vitro, this molecule may mediate the enhancement of phagocytosis upon interaction with soluble defense collagens (1, 2).

References

Kim, T.S. et al. (2000) Mol. Immunol. 37:377.
Dean, Y.D. and P. Gasque (2001) Eur. J. Immunol. 31:1370.

Long Name

Complement Component C1q Receptor

Entrez Gene IDs

22918 (Human); 17064 (Mouse); 84398 (Rat)

Alternate Names

AA4 Antigen; C1q R1; C1q receptor 1; C1q Rp; C1q/MBL/SPA receptor; C1qR(P); C1qR1; C1qRp; CD93 antigenC1qR; CD93 molecule; CD93; CDw93C1QR1; Collectin Receptor; Complement component 1 q subcomponent receptor 1; complement component 1, q subcomponent, receptor 1; complement component C1q receptor; dJ737E23.1; ECSM3; Ly68; Matrix-remodeling-associated protein 4; matrix-remodelling associated 4; MXRA4

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citations for Human C1qR1/CD93 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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Significance of Soluble CD93 in Type 2 Diabetes as a Biomarker for Diabetic Nephropathy: Integrated Results from Human and Rodent Studies
Authors: M Lee, HS Park, MY Choi, HZ Kim, SJ Moon, JY Ha, A Choi, YW Park, JS Park, EC Shin, CW Ahn, S Kang
J Clin Med, 2020-05-08;9(5):.
Species: Mouse
Sample Types: Serum
Applications: ELISA (detection)
Soluble CD93 is an apoptotic cell opsonin recognized by ?x ?2
Authors: JWD Blackburn, DHC Lau, EY Liu, J Ellins, AM Vrieze, EN Pawlak, JD Dikeakos, B Heit
Eur. J. Immunol., 2019-02-07;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: ICC
Elevated expression of CD93 promotes angiogenesis and tumor growth in nasopharyngeal carcinoma
Authors: Lili Bao
Biochem Biophys Res Commun, 2016-05-30;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-Fr
Soluble CD93 levels in patients with acute myocardial infarction and its implication on clinical outcome.
Authors: Youn J, Yu H, Jeon J, Lee H, Jang Y, Park Y, Park Y, Shin E, Ha J
PLoS ONE, 2014-05-06;9(5):e96538.
Species: Human
Sample Types: Serum
Applications: ELISA Development (Detection)
Plasma CD93 concentration is a potential novel biomarker for coronary artery disease.
Authors: Malarstig A, Silveira A, Wagsater D, Ohrvik J, Backlund A, Samnegard A, Khademi M, Hellenius ML, Leander K, Olsson T, Uhlen M, de Faire U, Eriksson P, Hamsten A
J. Intern. Med., 2011-03-21;270(0):229-36.
Species: Human
Sample Types: Plasma
Applications: ELISA Development