Human FXR/NR1H4 Antibody

Catalog #: AF3554 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
AF3554
AF3554-SP

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All FXR/NR1H4 Antibodies

Product Details

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human FXR/NR1H4 Antibody Summary

Species Reactivity

Human

Specificity

Detects human FXR/NR1H4 in direct ELISAs and Western blots.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human FXR/NR1H4
Leu211-Gln486
Accession # Q96RI1

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

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Applications

Recommended Concentration

Sample

Western Blot

0.1 µg/mL

Recombinant Human FXR/NR1H4

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Reconstitution Buffer Available

Reconstitution Buffer 1 (PBS)

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: FXR/NR1H4

FXR is a 56 kDa nuclear receptor belonging to the NR1 subfamily. It is highly expressed in liver, intestine, kidney and white adipose tissue. FXR binds bile acids and functions as a transcription activator or repressor through interactions with a large variety of FXR response elements. Human and mouse FXR share approximately 92% amino acid sequence identity.

Long Name

Farnesoid X-activated receptor

Entrez Gene IDs

9971 (Human); 20186 (Mouse); 60351 (Rat)

Alternate Names

BAR; bile acid receptor; farnesoid X receptor; Farnesoid X-activated receptor; Farnesol receptor HRR-1; FXR; FXRBAR; HRR-1; HRR1MGC163445; NR1H4; Nuclear receptor subfamily 1 group H member 4; nuclear receptor subfamily 1, group H, member 4; Retinoid X receptor-interacting protein 14; RIP14; RIP14RXR-interacting protein 14