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Human/Mouse/Rat TrkB Antibody

Catalog #: AF1494
80 Citations 5 Reviews Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
AF1494
AF1494-SP
Detection of Human, Mouse, and Rat TrkB by Western Blot.
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Citations (80)
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Reviews (5)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human/Mouse/Rat TrkB Antibody Summary

Species Reactivity
Human, Mouse, Rat
Specificity
Detects mouse TrkB in direct ELISAs. Detects human, mouse, and rat TrkB in Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse TrkB
Cys32-His429
Accession # P15209
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.1-0.5 µg/mL
See below
Simple Western
10 µg/mL
See below
Immunohistochemistry
5-15 µg/mL
See below
Blockade of Receptor-ligand Interaction
In a functional ELISA, 0.5-2 µg/mL of this antibody will block 50% of the binding of 5 ng/mL of biotinylated recombinant Human BDNF to immobilized Recombinant Mouse TrkB (Catalog # 1494-TB) coated at 2 µg/mL (100 µL/well). At 50 μg/mL, this antibody will block >90% of the binding.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human, Mouse, and Rat TrkB antibody by Western Blot. View Larger

Detection of Human, Mouse, and Rat TrkB by Western Blot. Western blot shows lysates of human brain (motor cortex) tissue, mouse brain (cortex) tissue, and rat brain (hippocampus) tissue. PVDF membrane was probed with 0.1 µg/mL of Goat Anti-Human/Mouse/Rat TrkB Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1494) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF017). Specific bands were detected for TrkB at approximately 95 kDa and 145 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Western Blot Detection of Mouse TrkB antibody by Western Blot. View Larger

Detection of Mouse TrkB by Western Blot. Western blot shows lysates of mouse brain (cerebellum) tissue and mouse brain (cortex) tissue. PVDF membrane was probed with 0.5 µg/mL of Goat Anti-Human/Mouse/Rat TrkB Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1494) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF017). Specific bands were detected for TrkB at approximately 90-100 and 140 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Immunohistochemistry TrkB antibody in Mouse Spinal Cord by Immunohistochemistry (IHC-Fr). View Larger

TrkB in Mouse Spinal Cord. TrkB was detected in perfusion fixed frozen sections of mouse spinal cord using Goat Anti-Human/Mouse/Rat TrkB Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1494) at 1.7 µg/mL overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; NL001) and counterstained with DAPI (blue). Specific staining was localized to neuronal processes and cell bodies. View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections.

Simple Western Detection of Mouse TrkB antibody by Simple Western<sup>TM</sup>. View Larger

Detection of Mouse TrkB by Simple WesternTM. Simple Western lane view shows lysates of mouse brain (cortex) tissue, loaded at 0.2 mg/mL. A specific band was detected for TrkB at approximately 154 kDa (as indicated) using 10 µg/mL of Goat Anti-Human/Mouse/Rat TrkB Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1494) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: TrkB

The neurotrophins, including NGF, BDNF, NT-3, and NT-4/5, constitute a group of structurally related, secreted proteins that play an important role in the development and function of the nervous system. The biological activities of the neurotrophins are mediated by binding to and activating two unrelated receptor types: the p75 neurotrophin receptor (p75NTR) and the Trk family of receptor tyrosine kinases (1, 2). p75NTR is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and has been designated TNFRSF16. It binds all neurotrophins with low affinity to transduce cellular signaling pathways that synergize with or antagonize those activated by the Trk receptors. Three Trk family proteins, TrkA, TrkB, and TrkC, exhibiting different ligand specificities, have been identified. TrkA binds NGF and NT-3, TrkB binds BDNF, NT-3, and NT-4/5, and TrkC only binds NT-3 (1-2). All Trk family proteins share a conserved, complex subdomain organization consisting of a signal peptide, two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in the extracellular region, as well as an intracellular region that contains the tyrosine kinase domain (3). Natural splice variants of the different Trks, lacking the first cysteine-rich domain, the first and second or all three of the leucine-rich motifs, or the tyrosine kinase domain, have been described (4). At the protein sequence level, human and mouse TrkB show 94% amino acid sequence identity (5-6). The proteins also exhibit cross-species activity. The primary location of TrkB expression is in the central and peripheral nervous systems. Low level TrkB expression has also been observed in a wide variety of tissues outside the nervous system (6).

References
  1. Huang, E.J. and L.F. Reichardt (2003) Annu. Rev. Biochem. 72:609.
  2. Dechant, G. (2001) Cell Tissue Res. 305:229.
  3. Schneider, R. and M. Schweiger (1991) Oncogene 6:1807.
  4. Ninkina, N. et al. (1997) J. Biol. Chem. 272:13019.
  5. Nakagawara A. et al. (1995) Genomics. 25:538.
  6. Klein, R. et al. (1989) EMBO J. 8:3701.
Long Name
Neurotrophic Tyrosine Kinase Receptor B
Entrez Gene IDs
4915 (Human); 18212 (Mouse); 25054 (Rat)
Alternate Names
BDNF/NT-3 growth factors receptor; EC 2.7.10; EC 2.7.10.1; GP145-TrkB; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; NTRK2; TrkB tyrosine kinase; TrkB; trk-B; TRKBBDNF-tropomyosine receptor kinase B; tyrosine kinase receptor B

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Citations for Human/Mouse/Rat TrkB Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

80 Citations: Showing 1 - 10
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  1. Linking Hypothermia and Altered Metabolism with TrkB Activation
    Authors: Okko Alitalo, Gemma González-Hernández, Marko Rosenholm, Piia Kohtala, Nobuaki Matsui, Heidi Kaastrup Müller et al.
    ACS Chemical Neuroscience
  2. Identification of Trigeminal Sensory Neuronal Types Innervating Masseter Muscle
    Authors: Karen A. Lindquist, Sergei Belugin, Anahit H. Hovhannisyan, Tatiana M. Corey, Adam Salmon, Armen N. Akopian
    eNeuro
  3. TrkB/BDNF signalling patterns the sympathetic nervous system
    Authors: Jennifer C. Kasemeier-Kulesa, Jason A. Morrison, Frances Lefcort, Paul M. Kulesa
    Nature Communications
  4. BDNF-dependent modulation of axonal transport is selectively impaired in ALS
    Authors: AP Tosolini, JN Sleigh, S Surana, ER Rhymes, SD Cahalan, G Schiavo
    Acta neuropathologica communications, 2022-08-22;10(1):121.
  5. Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex‐dependent
    Authors: Mayur Patil, Anahit H. Hovhannisyan, Andi Wangzhou, Jennifer Mecklenburg, Wouter Koek, Vincent Goffin et al.
    Journal of Neuroendocrinology
  6. Breaking Mental Barriers Promotes Recovery After Spinal Cord Injury
    Authors: Haven I. Rodocker, Arman Bordbar, Molly J. E. Larson, Rebecca G. Biltz, Lynde Wangler, Paolo Fadda et al.
    Frontiers in Molecular Neuroscience
  7. The Presynaptic Scaffold Protein Bassoon in Forebrain Excitatory Neurons Mediates Hippocampal Circuit Maturation: Potential Involvement of TrkB Signalling
    Authors: Anil Annamneedi, Miguel del Angel, Eckart D. Gundelfinger, Oliver Stork, Gürsel Çalışkan
    International Journal of Molecular Sciences
  8. Perineuronal Net Receptor PTP sigma Regulates Retention of Memories
    Authors: Angelina Lesnikova, Plinio Casarotto, Rafael Moliner, Senem Merve Fred, Caroline Biojone, Eero Castrén
    Frontiers in Synaptic Neuroscience
  9. AraC interacts with p75NTR transmembrane domain to induce cell death of mature neurons
    Authors: Lopes-Rodrigues, V;Boxy, P;Sim, E;Park, DI;Habeck, M;Carbonell, J;Andersson, A;Fernández-Suárez, D;Nissen, P;Nykjær, A;Kisiswa, L;
    Cell death & disease
  10. The Role of TRESK in Discrete Sensory Neuron Populations and Somatosensory Processing
    Authors: Greg A. Weir, Philippa Pettingill, Yukyee Wu, Galbha Duggal, Andrei-Sorin Ilie, Colin J. Akerman et al.
    Frontiers in Molecular Neuroscience
  11. Transactivation of TrkB Receptors by Oxytocin and Its G Protein-Coupled Receptor
    Authors: Mariela Mitre, Khalil Saadipour, Kevin Williams, Latika Khatri, Robert C. Froemke, Moses V. Chao
    Frontiers in Molecular Neuroscience
  12. Selective activation and down‐regulation of Trk receptors by neurotrophins in human neurons co‐expressing TrkB and TrkC
    Authors: Sarah Ateaque, Spyros Merkouris, Sean Wyatt, Nicholas D. Allen, Jia Xie, Peter S. DiStefano et al.
    Journal of Neurochemistry
  13. Boundary cap neural crest stem cells homotopically implanted to the injured dorsal root transitional zone give rise to different types of neurons and glia in adult rodents.
    Authors: Trolle, Carl, Konig, Niclas, Abrahamsson, Ninnie, Vasylovska, Svitlana, Kozlova, Elena N
    BMC Neurosci, 2014-05-05;15(0):60.
  14. Elp1 is required for development of visceral sensory peripheral and central circuitry
    Authors: Zariah Tolman, Marta Chaverra, Lynn George, Frances Lefcort
    Disease Models & Mechanisms
  15. Dynamic expression of transcription factor Brn3b during mouse cranial nerve development
    Authors: Szilard Sajgo, Seid Ali, Octavian Popescu, Tudor Constantin Badea
    Journal of Comparative Neurology
  16. Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy
    Authors: Luisa Hennlein, Hanaa Ghanawi, Florian Gerstner, Eduardo Palominos García, Ezgi Yildirim, Lena Saal-Bauernschubert et al.
    Journal of Cell Biology
  17. Antidepressant drugs act by directly binding to TRKB neurotrophin receptors
    Authors: Plinio C. Casarotto, Mykhailo Girych, Senem M. Fred, Vera Kovaleva, Rafael Moliner, Giray Enkavi et al.
    Cell
  18. The Responsiveness of TrkB to BDNF and Antidepressant Drugs Is Differentially Regulated during Mouse Development
    Authors: Antonio Di Lieto, Tomi Rantamäki, Liisa Vesa, Sudhirkumar Yanpallewar, Hanna Antila, Jesse Lindholm et al.
    PLoS ONE
  19. In vivo survival and differentiation of Friedreich ataxia iPSC-derived sensory neurons transplanted in the adult dorsal root ganglia
    Authors: Viventi S, Frausin S, Howden SE et al.
    Stem cells translational medicine
  20. Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice
    Authors: C Rivat, C Sar, I Mechaly, JP Leyris, L Diouloufet, C Sonrier, Y Philipson, O Lucas, S Mallié, A Jouvenel, A Tassou, H Haton, S Venteo, JP Pin, E Trinquet, F Charrier-S, A Mezghrani, W Joly, J Mion, M Schmitt, A Pattyn, F Marmigère, P Sokoloff, P Carroll, D Rognan, J Valmier
    Nat Commun, 2018-03-12;9(1):1042.
  21. Critical roles of embryonic born dorsal dentate granule neurons for activity-dependent increases in BDNF, adult hippocampal neurogenesis, and anti-anxiety-like behaviors
    Authors: Dong Sun, Leena Milibari, Jin-Xiu Pan, Xiao Ren, Ling-Ling Yao, Yang Zhao et al.
    Biological Psychiatry
  22. Role of DSCAM in the development of the spinal locomotor and sensorimotor circuits
    Authors: Louise Thiry, Maxime Lemieux, Olivier D. Laflamme, Frédéric Bretzner
    Journal of Neurophysiology
  23. Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene
    Authors: Gupta, R;Dittmeier, M;Wohlleben, G;Nickl, V;Bischler, T;Luzak, V;Wegat, V;Doll, D;Sodmann, A;Bady, E;Langlhofer, G;Wachter, B;Havlicek, S;Gupta, J;Horn, E;Lüningschrör, P;Villmann, C;Polat, B;Wischhusen, J;Monoranu, CM;Kuper, J;Blum, R;
    Cancer gene therapy
    Species: Human
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  24. Dopaminergic Input Regulates the Sensitivity of Indirect Pathway Striatal Spiny Neurons to Brain-Derived Neurotrophic Factor
    Authors: Ayon-Olivas, M;Wolf, D;Andreska, T;Granado, N;Lüningschrör, P;Ip, CW;Moratalla, R;Sendtner, M;
    Biology
    Species: Mouse
    Sample Types: Cell Lysates, Whole Cells, Whole Tissue
    Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
  25. Psychedelics promote plasticity by directly binding to BDNF receptor TrkB
    Authors: Moliner, R;Girych, M;Brunello, CA;Kovaleva, V;Biojone, C;Enkavi, G;Antenucci, L;Kot, EF;Goncharuk, SA;Kaurinkoski, K;Kuutti, M;Fred, SM;Elsilä, LV;Sakson, S;Cannarozzo, C;Diniz, CRAF;Seiffert, N;Rubiolo, A;Haapaniemi, H;Meshi, E;Nagaeva, E;Öhman, T;Róg, T;Kankuri, E;Vilar, M;Varjosalo, M;Korpi, ER;Permi, P;Mineev, KS;Saarma, M;Vattulainen, I;Casarotto, PC;Castrén, E;
    Nature neuroscience
    Species: Human, Rat, Transgenic Mouse
    Sample Types: Cell Lysates, Whole Cells
    Applications: Bioassay, Immunoprecipitation, Western Blot, Immunocytochemistry, ELISA Capture
  26. Sensory innervation of masseter, temporal and lateral pterygoid muscles in common marmosets
    Authors: AH Hovhannisy, KA Lindquist, S Belugin, J Mecklenbur, J Merlo, M Tram, TM Corey, AB Salmon, D Perez, S Ruparel, AN Akopian
    bioRxiv : the preprint server for biology, 2023-04-26;0(0):.
    Species: Marmoset
    Sample Types: Whole Tissue
    Applications: IHC
  27. Morin post-treatment surpassed calpeptin in ameliorating 3-NP-induced cortical neurotoxicity via modulation of glutamate/calpain axis, Kidins220, and BDNF/TrkB/AKT/CREB trajectory
    Authors: OE Mohamed, DM Abdallah, AM Fayez, RA Mohamed, HS El-Abhar
    International immunopharmacology, 2023-02-01;116(0):109771.
    Species: Rat
    Sample Types: Protein
    Applications: Western Blot
  28. nNOS-induced tyrosine nitration of TRKB impairs BDNF signaling and restrains neuronal plasticity
    Authors: C Biojone, P C Casarott, C Cannarozzo, SM Fred, R Herrera-Ro, A Lesnikova, M Voipio, E Castrén
    Progress in neurobiology, 2023-01-20;222(0):102413.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Cells
    Applications: ELISA Capture
  29. Closing the Gap between the Auditory Nerve and Cochlear Implant Electrodes: Which Neurotrophin Cocktail Performs Best for Axonal Outgrowth and Is Electrical Stimulation Beneficial?
    Authors: D Schmidbaue, S Fink, F Rousset, H Löwenheim, P Senn, R Glueckert
    International Journal of Molecular Sciences, 2023-01-19;24(3):.
    Species: Mouse
    Sample Types: Organoid
    Applications: IHC
  30. Serotonin Receptor 5-HT2A Regulates TrkB Receptor Function in Heteroreceptor Complexes
    Authors: T Ilchibaeva, A Tsybko, A Zeug, FE Müller, D Guseva, S Bischoff, E Ponimaskin, V Naumenko
    Cells, 2022-08-02;11(15):.
    Species: Mouse
    Sample Types: Cell Lysate, Whole Cells, Whole Tissue
    Applications: IHC, Immunoprecipitation, Western Blot
  31. Dental pulp stem cells stimulate neuronal differentiation of PC12 cells
    Authors: N Sultan, LE Amin, AR Zaher, ME Grawish, BA Scheven
    Neural regeneration research, 2021-09-01;16(9):1821-1828.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Neutralization
  32. ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma
    Authors: F De Bacco, F Orzan, J Erriquez, E Casanova, L Barault, R Albano, A D'Ambrosio, V Bigatto, G Reato, M Patanè, B Pollo, G Kuesters, C Dell'Aglio, L Casorzo, S Pellegatta, G Finocchiar, PM Comoglio, C Boccaccio
    Cell Reports, 2021-07-27;36(4):109455.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: Flow Cytometry, Western Blot
  33. Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome
    Authors: BA Karpinski, TM Maynard, CA Bryan, G Yitsege, A Horvath, NH Lee, SA Moody, AS LaMantia
    Disease Models & Mechanisms, 2021-05-04;15(2):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  34. Cyclic Stretch of Either PNS or CNS Located Nerves Can Stimulate Neurite Outgrowth
    Authors: V Kampanis, B Tolou-Dabb, L Zhou, W Roth, R Puttagunta
    Cells, 2020-12-28;10(1):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  35. Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates
    Authors: L Faure, Y Wang, ME Kastriti, P Fontanet, KKY Cheung, C Petitpré, H Wu, LL Sun, K Runge, L Croci, MA Landy, HC Lai, GG Consalez, A de Chevign, F Lallemend, I Adameyko, S Hadjab
    Nat Commun, 2020-08-21;11(1):4175.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  36. Soluble SORLA enhances neurite outgrowth and regeneration through activation of the EGF Receptor/ERK signaling axis
    Authors: J Stupack, XP Xiong, LL Jiang, T Zhang, L Zhou, A Campos, B Ranscht, W Mobley, EB Pasquale, H Xu, TY Huang
    J. Neurosci., 2020-06-29;0(0):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  37. Generation of self-organized sensory ganglion organoids and retinal ganglion cells from fibroblasts
    Authors: D Xiao, Q Deng, Y Guo, X Huang, M Zou, J Zhong, P Rao, Z Xu, Y Liu, Y Hu, Y Shen, K Jin, M Xiang
    Sci Adv, 2020-05-29;6(22):eaaz5858.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  38. Ameloblastomas Exhibit Stem Cell Potential, Possess Neurotrophic Properties, and Establish Connections with Trigeminal Neurons
    Authors: P Pagella, J Catón, CT Meisel, TA Mitsiadis
    Cells, 2020-03-06;9(3):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  39. The Rare IL22RA2 Signal Peptide Coding Variant rs28385692 Decreases Secretion of IL-22BP Isoform-1, -2 and -3 and Is Associated with Risk for Multiple Sclerosis
    Authors: P Gómez-Fern, A Lopez de L, I Astobiza, J Mena, A Urtasun, V Altmann, F Matesanz, D Otaegui, E Urcelay, A Antigüedad, S Malhotra, X Montalban, T Castillo-T, L Espino-Pai, O Aktas, M Buttmann, A Chan, B Fontaine, PA Gourraud, M Hecker, S Hoffjan, C Kubisch, T Kümpfel, F Luessi, UK Zettl, F Zipp, I Alloza, M Comabella, CM Lill, K Vandenbroe
    Cells, 2020-01-10;9(1):.
    Species: Mouse
    Sample Types: Cell Lysate
    Applications: Western Blot
  40. Therapeutic Potential of AAV1-Rheb(S16H) Transduction Against Alzheimer's Disease
    Authors: GJ Moon, S Kim, MT Jeon, KJ Lee, IS Jang, M Nakamura, SR Kim
    J Clin Med, 2019-11-22;8(12):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  41. Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2
    Authors: SM Fred, L Laukkanen, CA Brunello, L Vesa, H Göös, I Cardon, R Moliner, T Maritzen, M Varjosalo, PC Casarotto, E Castrén
    J. Biol. Chem., 2019-10-20;0(0):.
    Species: Mouse, Rat
    Sample Types: Tissue Homogenates, Whole Cells
    Applications: ELISA Capture, ICC, Immunoprecipitation, Western Blot
  42. A cell fitness selection model for neuronal survival during development
    Authors: Y Wang, H Wu, P Fontanet, S Codeluppi, N Akkuratova, C Petitpré, Y Xue-Franzé, K Niederreit, A Sharma, F Da Silva, G Comai, G Agirman, D Palumberi, S Linnarsson, I Adameyko, A Moqrich, A Schedl, G La Manno, S Hadjab, F Lallemend
    Nat Commun, 2019-09-12;10(1):4137.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  43. Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch
    Authors: D Acton, X Ren, S Di Costanz, A Dalet, S Bourane, I Bertocchi, C Eva, M Goulding
    Cell Rep, 2019-07-16;28(3):625-639.e6.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  44. Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain
    Authors: M Richner, LT Pallesen, M Ulrichsen, ET Poulsen, TH Holm, H Login, A Castonguay, LE Lorenzo, NP Gonçalves, OM Andersen, K Lykke-Hart, JJ Enghild, LCB Rønn, IJ Malik, Y De Koninck, OJ Bjerrum, CB Vægter, A Nykjær
    Sci Adv, 2019-06-19;5(6):eaav9946.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  45. Notch signalling defines dorsal root ganglia neuroglial fate choice during early neural crest cell migration
    Authors: S Wiszniak, Q Schwarz
    BMC Neurosci, 2019-04-29;20(1):21.
    Species: Human
    Sample Types: Whole Tissues
    Applications: IHC-F
  46. Functional Local Proprioceptive Feedback Circuits Initiate and Maintain Locomotor Recovery after Spinal Cord Injury
    Authors: A Takeoka, S Arber
    Cell Rep, 2019-04-02;27(1):71-85.e3.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  47. Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA
    Authors: S Desiderio, S Vermeiren, C Van Campen, S Kricha, E Malki, S Richts, EV Fletcher, T Vanwelden, BZ Schmidt, KA Henningfel, T Pieler, CG Woods, V Nagy, C Verfaillie, EJ Bellefroid
    Cell Rep, 2019-03-26;26(13):3522-3536.e5.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  48. PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis
    Authors: L Bartesaghi, Y Wang, P Fontanet, S Wanderoy, F Berger, H Wu, N Akkuratova, F Bouçanova, JJ Médard, C Petitpré, MA Landy, MD Zhang, P Harrer, C Stendel, R Stucka, M Dusl, ME Kastriti, L Croci, HC Lai, GG Consalez, A Pattyn, P Ernfors, J Senderek, I Adameyko, F Lallemend, S Hadjab, R Chrast
    Cell Rep, 2019-03-26;26(13):3484-3492.e4.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  49. Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice
    Authors: M Zhang, Y Wang, J Geng, S Zhou, B Xiao
    Cell Rep, 2019-02-05;26(6):1419-1431.e4.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  50. Characteristics of sensory neuronal groups in CGRP-cre-ER reporter mice: Comparison to Nav1.8-cre, TRPV1-cre and TRPV1-GFP mouse lines
    Authors: MJ Patil, AH Hovhannisy, AN Akopian
    PLoS ONE, 2018-06-04;13(6):e0198601.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  51. The TrkB agonist 7,8-dihydroxyflavone changes the structural dynamics of neocortical pyramidal neurons and improves object recognition in mice
    Authors: M Perez-Rand, E Castillo-G, C Bueno-Fern, J Nacher
    Brain Struct Funct, 2018-03-02;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  52. Protection of nigral dopaminergic neurons by AAV1 transduction with Rheb(S16H) against neurotoxic inflammation in vivo
    Authors: S Kim, GJ Moon, YS Oh, J Park, WH Shin, JY Jeong, KS Choi, BK Jin, N Kholodilov, RE Burke, HJ Kim, CM Ha, SG Lee, SR Kim
    Exp. Mol. Med., 2018-02-09;50(2):e440.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  53. Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells
    Authors: AJ Alshawaf, S Viventi, W Qiu, G D'Abaco, B Nayagam, M Erlichster, G Chana, I Everall, J Ivanusic, E Skafidas, M Dottori
    Sci Rep, 2018-01-12;8(1):603.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  54. Treadmill exercise suppressed stress-induced dendritic spine elimination in mouse barrel cortex and improved working memory via BDNF/TrkB pathway
    Authors: K Chen, L Zhang, M Tan, CS Lai, A Li, C Ren, KF So
    Transl Psychiatry, 2017-03-21;7(3):e1069.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  55. Genetic Tracing of Cav3.2 T-Type Calcium Channel Expression in the Peripheral Nervous System
    Authors: YA Bernal Sie, J Haseleu, A Kozlenkov, V Bégay, GR Lewin
    Front Mol Neurosci, 2017-03-15;10(0):70.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  56. Development of a pharmacodynamic biomarker to measure target engagement from inhibition of the NGF-TrkA pathway
    Authors: EA Price, A Krasowska-, KK Nanda, SJ Stachel, DA Henze
    J. Neurosci. Methods, 2017-03-07;282(0):34-42.
    Species: Rat
    Sample Types: Tissue Homogenates
    Applications: ELISA Development (Capture)
  57. Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In�Vivo
    Authors: N Guimar?es-, P Cattaneo, Y Sun, T Moore-Morr, Y Gu, ND Dalton, E Rockenstei, E Masliah, KL Peterson, WB Stallcup, J Chen, SM Evans
    Cell Stem Cell, 2017-01-19;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  58. Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes
    Authors: EG Reed-Geagh, MC Wright, LA See, PC Adelman, KH Lee, HR Koerber, SM Maricich
    J Neurosci, 2016-04-13;36(15):4362-76.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  59. KCNQ Potassium Channels Modulate Sensitivity of Skin Down-hair (D-hair) Mechanoreceptors
    Authors: S Schütze, IJ Orozco, TJ Jentsch
    J. Biol. Chem, 2016-01-05;291(11):5566-75.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  60. Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing.
    Authors: Usoskin D, Furlan A, Islam S, Abdo H, Lonnerberg P, Lou D, Hjerling-Leffler J, Haeggstrom J, Kharchenko O, Kharchenko P, Linnarsson S, Ernfors P
    Nat Neurosci, 2014-11-24;18(1):145-53.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  61. Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling.
    Authors: Gatto G, Dudanova I, Suetterlin P, Davies A, Drescher U, Bixby J, Klein R
    J Neurosci, 2013-03-20;33(12):5399-410.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  62. Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.
    Authors: Vaegter CB, Jansen P, Fjorback AW
    Nat. Neurosci., 2010-11-21;14(1):54-61.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  63. Embryonic sympathoblasts transiently express TrkB in vivo and proliferate in response to brain-derived neurotrophic factor in vitro.
    Authors: Straub JA, Sholler GL, Nishi R
    BMC Dev. Biol., 2007-02-19;7(0):10.
    Species: Chicken, Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  64. Chondroitinase and Antidepressants Promote Plasticity by Releasing TRKB from Dephosphorylating Control of PTP sigma in Parvalbumin Neurons
    Authors: Angelina Lesnikova, Plinio Cabrera Casarotto, Senem Merve Fred, Mikko Voipio, Frederike Winkel, Anna Steinzeig et al.
    The Journal of Neuroscience
  65. Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors
    Authors: Cassiano R.A.F. Diniz, Caroline Biojone, Samia R.L. Joca, Tomi Rantamäki, Eero Castrén, Francisco S. Guimarães et al.
    PeerJ
  66. Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability
    Authors: John M. Dawes, Greg A. Weir, Steven J. Middleton, Ryan Patel, Kim I. Chisholm, Philippa Pettingill et al.
    Neuron
  67. Unipotent, Atoh1+ progenitors maintain the Merkel cell population in embryonic and adult mice
    Authors: Margaret C. Wright, Erin G. Reed-Geaghan, Alexa M. Bolock, Tomoyuki Fujiyama, Mikio Hoshino, Stephen M. Maricich
    Journal of Cell Biology
  68. Mapping of Sensory Nerve Subsets within the Vagal Ganglia and the Brainstem Using Reporter Mice for Pirt, TRPV1, 5-HT3, and Tac1 Expression
    Authors: Seol-Hee Kim, Stephen H. Hadley, Mikayla Maddison, Mayur Patil, Byeong Cha, Marian Kollarik et al.
    eNeuro
  69. Tissue-Specificity of Antibodies Raised Against TrkB and p75NTR Receptors; Implications for Platelets as Models of Neurodegenerative Diseases
    Authors: Fleury S, Boukhatem I, Le Blanc J et al.
    Frontiers in Immunology
  70. Neurotrophic interactions between neurons and astrocytes following AAV1‐Rheb(S16H) transduction in the hippocampus in vivo
    Authors: Min‐Tae Jeon, Gyeong Joon Moon, Sehwan Kim, Minji Choi, Yong‐Seok Oh, Dong Woon Kim et al.
    British Journal of Pharmacology
  71. Merkel cells are long-lived cells whose production is stimulated by skin injury✰
    Authors: Margaret C. Wright, Gregory J. Logan, Alexa M. Bolock, Adam C. Kubicki, Julie A. Hemphill, Timothy A. Sanders et al.
    Developmental Biology
  72. A Long-Term Energy-Rich Diet Increases Prefrontal BDNF in Sprague-Dawley Rats
    Authors: Alessandro Virtuoso, Pernille Tveden-Nyborg, Anne Marie Voigt Schou-Pedersen, Jens Lykkesfeldt, Heidi Kaastrup Müller, Betina Elfving et al.
    Nutrients
  73. Impaired dynamic interaction of axonal endoplasmic reticulum and ribosomes contributes to defective stimulus–response in spinal muscular atrophy
    Authors: Chunchu Deng, Sebastian Reinhard, Luisa Hennlein, Janna Eilts, Stefan Sachs, Sören Doose et al.
    Translational Neurodegeneration
  74. Genetic interplay between transcription factor Pou4f1/Brn3a and neurotrophin receptor Ret in retinal ganglion cell type specification
    Authors: Vladimir Vladimirovich Muzyka, Tudor Constantin Badea
    Neural Development
  75. Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model
    Authors: Georgia-Ioanna Kartalou, Ana Rita Salgueiro-Pereira, Thomas Endres, Angelina Lesnikova, Plinio Casarotto, Paula Pousinha et al.
    International Journal of Molecular Sciences
  76. Identification of Spinal Neurons Contributing to the Dorsal Column Projection Mediating Fine Touch and Corrective Motor Movements
    Authors: Sónia Paixão, Laura Loschek, Louise Gaitanos, Pilar Alcalà Alcalà Morales, Martyn Goulding, Rüdiger Klein
    Neuron
  77. Caffeine-mediated BDNF release regulates long-term synaptic plasticity through activation of IRS2 signaling
    Authors: Cristina Lao-Peregrín, Jesús Javier Ballesteros, Miriam Fernández, Alfonsa Zamora-Moratalla, Ana Saavedra, María Gómez Lázaro et al.
    Addiction Biology
  78. Hair follicle epidermal stem cells define a niche for tactile sensation
    Authors: Chun-Chun Cheng, Ko Tsutsui, Toru Taguchi, Noriko Sanzen, Asako Nakagawa, Kisa Kakiguchi et al.
    eLife
  79. Muscle-selective RUNX3 dependence of sensorimotor circuit development
    Authors: Yiqiao Wang, Haohao Wu, Pavel Zelenin, Paula Fontanet, Simone Wanderoy, Charles Petitpré et al.
    Development
  80. Balance between BDNF and Semaphorins gates the innervation of the mammary gland
    Authors: Hadas Sar Shalom, Ron Goldner, Yarden Golan-Vaishenker, Avraham Yaron
    eLife

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Human/Mouse/Rat TrkB Antibody
By Anonymous on 07/15/2021
Application: Immunocytochemistry/Immunofluorescence Sample Tested: Hippocampal neurons Species: Mouse
Immunocytochemistry/Immunofluorescence Human/Mouse/Rat TrkB Antibody AF1494
Human/Mouse/Rat TrkB Antibody
By Anonymous on 05/03/2021
Application: WB Sample Tested: Brain (hypothalamus) tissue Species: Mouse
Western Blot Human/Mouse/Rat TrkB Antibody AF1494
Human/Mouse/Rat TrkB Antibody
By Anonymous on 11/22/2019
Application: Immunocytochemistry/Immunofluorescence Sample Tested: E12 DRG neurons Species: Mouse

E12 mouse DRG neurons grown overnight with 10ng/ml NGF, then fixed in 4% PFA, blocked for 1 h with 5% BSA, and incubated overnight in 1% BSA containing AF1494 (1:300). A fluorophore-conjugated secondary antibody was used to visualise reactivity.

Immunocytochemistry/Immunofluorescence Human/Mouse/Rat TrkB Antibody AF1494
Mouse TrkB Antibody
By Emily Thompson on 04/04/2019
Application: WB Sample Tested: Brain (cortex) tissue Species: Mouse
Western Blot Mouse TrkB Antibody AF1494
Mouse TrkB Antibody
By Juan Nacher on 09/12/2016
Application: IHC Sample Tested: Adult brain (hippocampus),Brain (cortex) tissue Species: Mouse
Immunohistochemistry Mouse TrkB Antibody AF1494