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Human NRL Antibody

Catalog #: AF2945
12 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
AF2945
AF2945-SP
Product Details
Citations (12)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human NRL Antibody Summary

Species Reactivity
Human
Specificity
Detects human NRL in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
E. coli-derived recombinant human NRL
Met1-Leu237
Accession # P54845
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Human NRL

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: NRL

NRL is a 30 kDa nuclear transcription factor that belongs to the Maf subfamily within the bZIP (basic motif-leucine zipper) transcription factor family. It contains an N‑terminal transcriptional activation domain and a C-terminal DNA-binding bZIP domain that is also involved in homo- or heterodimerization. NRL regulates the expression of rod-specific genes and is expressed specifically in rod photoreceptors. NRL is phosphorylated at multiple sites, which likely regulates its activity. The amino acid sequence of human NRL is 92%, 94%, 90% and 90% identical to that of bovine, canine, rat and mouse NRL, respectively.

Long Name
Neural Retina-specific Leucine Zipper Protein
Entrez Gene IDs
4901 (Human)
Alternate Names
D14S46Eneural retina-specific leucine zipper protein; neural retina leucine zipper; NRL; NRL-MAF; RP27; RP27neural retinal-specific leucine zipper

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Citations for Human NRL Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

12 Citations: Showing 1 - 10
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  1. Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution
    Authors: Cowan CS, Renner M, De Gennaro M et al.
    Cell
  2. Single-Cell Analysis of Human Retina Identifies Evolutionarily Conserved and Species-Specific Mechanisms Controlling Development
    Authors: Lu Y, Shiau F, Yi W et al.
    Dev. Cell
  3. Automating iPSC generation to enable autologous photoreceptor cell replacement therapy
    Authors: LR Bohrer, NE Stone, NK Mullin, AP Voigt, KR Anfinson, JL Fick, V Luangphakd, B Hittle, K Powell, GF Muschler, RF Mullins, EM Stone, BA Tucker
    Journal of Translational Medicine, 2023-02-28;21(1):161.
    Species: Human
    Sample Types: Organoid
    Applications: IHC
  4. Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
    Authors: Nguyet Le, Haley Appel, Nicole Pannullo, Thanh Hoang, Seth Blackshaw
    Frontiers in Cell and Developmental Biology
  5. One-step induction of photoreceptor-like cells from human iPSCs by delivering transcription factors
    Authors: Yuki Otsuka, Keiko Imamura, Akio Oishi, Takayuki Kondo, Mika Suga, Yuichiro Yada et al.
    iScience
  6. Addition of Chk1 inhibitor and BMP4 cooperatively promotes retinal tissue formation in self-organizing human pluripotent stem cell differentiation culture
    Authors: S Yamasaki, A Kuwahara, A Kishino, T Kimura, M Takahashi, M Mandai
    Regenerative Therapy, 2022-01-01;19(0):24-34.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  7. Biocompatibility of Human Induced Pluripotent Stem Cell-Derived Retinal Progenitor Cell Grafts in Immunocompromised Rats
    Authors: IC Han, LR Bohrer, KN Gibson-Cor, LA Wiley, A Shrestha, BE Harman, C Jiao, EH Sohn, R Wendland, BN Allen, KS Worthingto, RF Mullins, EM Stone, BA Tucker
    Cell Transplantation, 2022-01-01;31(0):9636897221104.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  8. A look into retinal organoids: methods, analytical techniques, and applications
    Authors: Afanasyeva TAV, Corral-Serrano JC, Garanto A et al.
    Cellular and Molecular Life Sciences
  9. Patient-Specific Retinal Organoids Recapitulate Disease Features of Late-Onset Retinitis Pigmentosa.
    Authors: Mei-Ling G, Xin-Lan L, Fang H et al.
    Front Cell Dev Biol.
  10. Preconditioning the Initial State of Feeder-free Human Pluripotent Stem Cells Promotes Self-formation of Three-dimensional Retinal Tissue
    Authors: A Kuwahara, S Yamasaki, M Mandai, K Watari, K Matsushita, M Fujiwara, Y Hori, Y Hiramine, D Nukaya, M Iwata, A Kishino, M Takahashi, Y Sasai, T Kimura
    Sci Rep, 2019-12-12;9(1):18936.
    Species: Human, Xenograft
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  11. NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma
    Authors: Alexandra Garancher, Charles Y. Lin, Morgane Morabito, Wilfrid Richer, Nathalie Rocques, Magalie Larcher et al.
    Cancer Cell
  12. Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors.
    Authors: Gonzalez-Cordero A, Kruczek K, Naeem A, Fernando M, Kloc M, Ribeiro J, Goh D, Duran Y, Blackford S, Abelleira-Hervas L, Sampson R, Shum I, Branch M, Gardner P, Sowden J, Bainbridge J, Smith A, West E, Pearson R, Ali R
    Stem Cell Reports, 2017-08-24;9(3):820-837.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC

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