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Human Prox1 Antibody

Catalog #: AF2727
148 Citations 2 Reviews Datasheet / COA / SDS
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AF2727
AF2727-SP
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Detection of Human Prox1 by Western Blot.
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Citations (148)
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Human Prox1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human Prox1 in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
E. coli-derived recombinant human Prox1
Pro2-Gln259
Accession # Q92786
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below
Simple Western
10 µg/mL
See below
Immunocytochemistry
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human Prox1 antibody by Western Blot. View Larger

Detection of Human Prox1 by Western Blot. Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human Prox1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2727) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for Prox1 at approximately 83 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Immunocytochemistry Prox1 antibody in HepG2 Human Hepatocellular Carcinoma Cell Line by Immunocytochemistry (ICC). View Larger

Prox1 in HepG2 Human Hepatocellular Carcinoma Cell Line. Prox1 was detected in immersion fixed HepG2 human hepatocellular carcinoma cell line using Goat Anti-Human Prox1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2727) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (left panel, red; Catalog # NL001) and counterstained with DAPI (right panel, blue). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Simple Western Detection of Human Prox1 antibody by Simple Western<SUP>TM</SUP>. View Larger

Detection of Human Prox1 by Simple WesternTM. Simple Western lane view shows lysates of HepG2 human hepatocellular carcinoma cell line, loaded at 0.2 mg/mL. A specific band was detected for Prox1 at approximately 114 kDa (as indicated) using 10 µg/mL of Goat Anti-Human Prox1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2727) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Western Blot Detection of Mouse Prox1 by Western Blot View Larger

Detection of Mouse Prox1 by Western Blot RNA-seq identifies the targets of GATA2 in primary human LECs. (A) Principal component analysis (PCA) was performed on RNA-seq data from control shRNA- and shGATA2-infected primary HLECs. A high level of similarity was observed within the groups as indicated by their proximity to each other. (B) Hierarchical clustering shows that approximately 1000 genes were consistently downregulated and 600 genes were upregulated in shGATA2-treated HLECs. (C) GO revealed a list of genes that are likely relevant to the phenotypes observed in mice lacking GATA2. (D) GATA2 was knocked out from a second HLEC line using CRISPR/Cas9. Western blot revealed the lack of GATA2 in the knockout cells (HLEC delta GATA2). In contrast, no obvious differences were observed in the expression of PROX1. Additionally, qRT-PCR revealed the downregulation of miR-126. (A) n=3 independent experiments per shRNA; (D) n=3 independent experiments (antibiotic selection, western blot and qRT-PCR). **P<0.01. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/31582413), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Mouse Prox1 by Western Blot View Larger

Detection of Mouse Prox1 by Western Blot Prox1 regulates myoblast differentiation.(a) Analysis of Prox1 mRNA and protein during C2C12 myoblast differentiation (indicated by the increase in MyoD1 mRNA). (b) Prox1 protein and mRNA in human myoblasts before and after differentiation. Primary myoblast lines from two different individuals were analysed. (c–f) Analysis of myoblast proliferation and differentiation-related CyclinD1, Myf5 and MyoD mRNAs in shProx1 and shScr transduced primary human myoblasts before (c) and after differentiation for 7d (d), as well as in mouse C2C12 myoblasts before (e) and after (f) differentiation. (g) Myosin staining of C2C12 cells after 7d of differentiation. Note that Prox1 silencing completely blocked myotube development, as only occasional cells expressed myosin and these cells were negative for shProx1-GFP. Data is presented as mean±s.e.m., n=3+3 biological replicates in a–g (all experiments were repeated three times). One-way analysis of variance with repeated measures followed by Tukey's posthoc test and Student's two-tailed unpaired t-test, *P<0.05, **P<0.01, ***P<0.001. Scale bars, 50 μm. Image collected and cropped by CiteAb from the following publication (https://www.nature.com/articles/ncomms13124), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Human Prox1 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Human Prox1 by Immunocytochemistry/Immunofluorescence In situ localization of Ptx3-LECs and transition between Ptx3-LECs and Marco-LECs in human LNs. (A) Expression of CD36/Cd36 in LN LEC subsets of human and mouse. Dots indicate mean log-normalized transcript count. (B–D) Identification of CD36high Ptx3-LECs in human head and neck LNs by immunostaining. (B,C) Immunofluorescence of PROX-1, MARCO and CD36 (B), or PROX-1, LYVE-1 and CLEC4M (C). Zoomed-in images (inset marked by blue dotted lines) in (B) and (C) demonstrate CD36high LYVE-1+ paracortical sinuses (filled arrowhead). Scale bars = 500 μm (left panels) and 100 μm (right panel inset). (D) CD36high LYVE-1+ Ptx3-LECs (filled arrowhead) can be seen associated with MARCO+ CLEC4M+ Marco-LECs (empty arrowhead) in human LNs. Scale bars = 100 μm. CD36high Ptx3-LECs were detected in four out of seven human LNs. Images are representative of four biological replicates. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/32426372), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Human Prox1 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Human Prox1 by Immunocytochemistry/Immunofluorescence In situ localization of Ptx3-LECs and transition between Ptx3-LECs and Marco-LECs in human LNs. (A) Expression of CD36/Cd36 in LN LEC subsets of human and mouse. Dots indicate mean log-normalized transcript count. (B–D) Identification of CD36high Ptx3-LECs in human head and neck LNs by immunostaining. (B,C) Immunofluorescence of PROX-1, MARCO and CD36 (B), or PROX-1, LYVE-1 and CLEC4M (C). Zoomed-in images (inset marked by blue dotted lines) in (B) and (C) demonstrate CD36high LYVE-1+ paracortical sinuses (filled arrowhead). Scale bars = 500 μm (left panels) and 100 μm (right panel inset). (D) CD36high LYVE-1+ Ptx3-LECs (filled arrowhead) can be seen associated with MARCO+ CLEC4M+ Marco-LECs (empty arrowhead) in human LNs. Scale bars = 100 μm. CD36high Ptx3-LECs were detected in four out of seven human LNs. Images are representative of four biological replicates. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/32426372), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Mouse Prox1 by Western Blot View Larger

Detection of Mouse Prox1 by Western Blot Prox1 regulates the slow muscle fibre gene program in skeletal muscle.(a) MyHC I (Myh7) expression in muscle fibres (arrows) in AAV8-Prox1 and AAV8-Ctrl transduced TA muscle. (b) Expression of myosin heavy chain and calcium-signalling genes in AAV8-Prox1 and AAV8-Ctrl transduced TA muscle. Note that the expression of slow fibre -specific genes are upregulated and fast MyHC genes downregulated in Prox1 overexpressing muscles. (c) Heat map from GSEA analysis showing that Prox1 overexpression in TA muscle leads to expression of many soleus specific myofibrillar genes (red colour indicates positive and blue negative enrichment). (d) Effect of Prox1 deletion on soleus muscle gene expression (HSA-CreERT2;Prox1fl/fl mice). Note the increased expression of fast MyHCs Myh2 and Myh4 RNAs, whereas slow troponin isoform RNAs and Myh7 RNA are decreased. (e) Deletion of Prox1 in slow soleus muscle with AAV-Cre leads to marked downregulation of MyHC I protein. Data is presented as mean±s.e.m., n=5+5 in a,b, n=3+3 in c, n=4+4 in d,e. Student's two-tailed unpaired t-test, *P<0.05, **P<0.01, ***P<0.001. Both overexpression and deletion experiments were conducted two times on independent mouse cohorts. WT, wild-type. Scale bars, 50 μm. Image collected and cropped by CiteAb from the following publication (https://www.nature.com/articles/ncomms13124), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Human Prox1 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Human Prox1 by Immunocytochemistry/Immunofluorescence In situ localization of Ptx3-LECs and transition between Ptx3-LECs and Marco-LECs in human LNs. (A) Expression of CD36/Cd36 in LN LEC subsets of human and mouse. Dots indicate mean log-normalized transcript count. (B–D) Identification of CD36high Ptx3-LECs in human head and neck LNs by immunostaining. (B,C) Immunofluorescence of PROX-1, MARCO and CD36 (B), or PROX-1, LYVE-1 and CLEC4M (C). Zoomed-in images (inset marked by blue dotted lines) in (B) and (C) demonstrate CD36high LYVE-1+ paracortical sinuses (filled arrowhead). Scale bars = 500 μm (left panels) and 100 μm (right panel inset). (D) CD36high LYVE-1+ Ptx3-LECs (filled arrowhead) can be seen associated with MARCO+ CLEC4M+ Marco-LECs (empty arrowhead) in human LNs. Scale bars = 100 μm. CD36high Ptx3-LECs were detected in four out of seven human LNs. Images are representative of four biological replicates. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/32426372), licensed under a CC-BY license. Not internally tested by R&D Systems.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Prox1

Prox1, the homologue of Drosophila Prospero, is a homeobox-containing transcription factor that binds and functions as a co-receptor of liver receptor homolog 1 (LRH1/NR5A2). It is a specific marker for lymphatic endothelial cells as well as hepatoblasts and hepatocytes. Human Prox1 shares 97% amino acid sequence homology with mouse and rat Prox1.

Long Name
Prospero-related Homeobox 1
Entrez Gene IDs
5629 (Human)
Alternate Names
Homeobox prospero-like protein PROX1; prospero homeobox 1; prospero homeobox protein 1; prospero-related homeobox 1; Prox1; PROX-1

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Citations for Human Prox1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

148 Citations: Showing 1 - 10
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  1. Angiopoietin-1 Knockout Mice as a Genetic Model of Open-Angle Glaucoma
    Authors: Thomson B, Grannonico M, Liu F et Al.
    Transl Vis Sci Technol
  2. Identification of Multiple Subsets of Ventral Interneurons and Differential Distribution along the Rostrocaudal Axis of the Developing Spinal Cord.
    Authors: Francius C, Harris A, Rucchin V et al.
    PLoS One.
  3. Molecular landscapes of human hippocampal immature neurons across lifespan
    Authors: Y Zhou, Y Su, S Li, BC Kennedy, DY Zhang, AM Bond, Y Sun, F Jacob, L Lu, P Hu, AN Viaene, I Helbig, SK Kessler, T Lucas, RD Salinas, X Gu, HI Chen, H Wu, JE Kleinman, TM Hyde, DW Nauen, DR Weinberger, GL Ming, H Song
    Nature, 2022-07-06;0(0):.
  4. Cardiac lymphatics are heterogeneous in origin and respond to injury.
    Authors: Klotz L, Norman S, Vieira JM et al.
    Nature.
  5. Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes
    Authors: Fujimoto N, He Y, D'Addio M et al.
    PLoS Biol.
  6. Phagocytosing differentiated cell-fragments is a novel mechanism for controlling somatic stem cell differentiation within a short time frame
    Authors: Wakao S, Oguma Y, Kushida Y et al.
    Research Square
  7. Hilar granule cells of the mouse dentate gyrus: effects of age, septotemporal location, strain, and selective deletion of the proapoptotic gene BAX
    Authors: K Bermudez-H, YL Lu, J Moretto, S Jain, JJ LaFrancois, AM Duffy, HE Scharfman
    Brain Struct Funct, 2017-03-17;0(0):.
  8. Genetic association analysis of 77,539 genomes reveals rare disease etiologies
    Authors: D Greene, Genomics E, D Pirri, K Frudd, E Sackey, M Al-Owain, APJ Giese, K Ramzan, S Riaz, I Yamanaka, N Boeckx, C Thys, BD Gelb, P Brennan, V Hartill, J Harvengt, T Kosho, S Mansour, M Masuno, T Ohata, H Stewart, K Taibah, CLS Turner, F Imtiaz, S Riazuddin, T Morisaki, P Ostergaard, BL Loeys, H Morisaki, ZM Ahmed, GM Birdsey, K Freson, A Mumford, E Turro
    Nature Medicine, 2023-03-16;29(3):679-688.
  9. Excess neuropeptides in lung signal through endothelial cells to impair gas exchange
    Authors: Xu J, Xu L, Sui P et al.
    Developmental cell
  10. Transcriptional, developmental, and functional parallels of lymphatic and venous smooth muscle
    Authors: Arroyo-Ataz, G;Yagüe, AC;Breda, JC;Mazzilli, SA;Jones, D;
    bioRxiv : the preprint server for biology
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  11. Involvement of Sigma Receptor-1 in Lymphatic Endothelial Barrier Integrity and Bioenergetic Regulation.
    Authors: Motawe Z Y, Abdelmaboud S S et al.
    Lymphat Res Biol
    Species: Human
    Sample Types:
    Applications: Simple Western
  12. Quantitative proteomics reveals CLR interactome in primary human cells
    Authors: Manolis, D;Hasan, S;Maraveyas, A;O'Brien, DP;Kessler, BM;Kramer, H;Nikitenko, LL;
    The Journal of biological chemistry
    Species: Human
    Sample Types: Whole Cells
    Applications: Immunocytochemistry
  13. Influenza Induces Lung Lymphangiogenesis Independent of YAP/TAZ Activity in Lymphatic Endothelial Cells
    Authors: Crossey, E;Carty, S;Shao, F;Henao-Vasquez, J;Ysasi, AB;Zeng, M;Hinds, A;Lo, M;Tilston-Lunel, A;Varelas, X;Jones, MR;Fine, A;
    Research square
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  14. JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens Fiber Maturation in Murine Lens Development
    Authors: Sun, Q;Li, J;Ma, J;Zheng, Y;Ju, R;Li, X;Ren, X;Huang, L;Chen, R;Tan, X;Luo, L;
    Investigative ophthalmology & visual science
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  15. Acquisition of neural fate by combination of BMP blockade and chromatin modification
    Authors: Agnes Lee Chen Ong, Toshiya Kokaji, Arisa Kishi, Yoshihiro Takihara, Takuma Shinozuka, Ren Shimamoto et al.
    iScience
  16. VEGFR3 is required for button junction formation in lymphatic vessels
    Authors: Jannaway, M;Iyer, D;Mastrogiacomo, DM;Li, K;Sung, DC;Yang, Y;Kahn, ML;Scallan, JP;
    Cell reports
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  17. Increasing adult neurogenesis protects mice from epilepsy
    Authors: Swati Jain, John J. LaFrancois, Kasey Gerencer, Justin J. Botterill, Meghan Kennedy, Chiara Criscuolo et al.
    bioRxiv
  18. PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway
    Authors: Ohata, H;Shiokawa, D;Sakai, H;Kanda, Y;Okimoto, Y;Kaneko, S;Hamamoto, R;Nakagama, H;Okamoto, K;
    Cell reports
    Species: Xenograft, Human
    Sample Types: Organoid, Whole Tissue
    Applications: IHC
  19. Gata3 is Required in Late Proneurosensory Development for Proper Sensory Cell Formation and Organization
    Authors: PV Blinkiewic, MR Long, ZA Stoner, EM Ketchum, SN Sheltz-Kem, JS Duncan
    Research square, 2023-04-14;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  20. The blood vasculature instructs lymphatic patterning in a SOX7‐dependent manner
    Authors: Ivy K N Chiang, Matthew S Graus, Nils Kirschnick, Tara Davidson, Winnie Luu, Richard Harwood et al.
    The EMBO Journal
  21. A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature
    Authors: J Kazenwadel, P Venugopal, A Oszmiana, J Toubia, L Arriola-Ma, V Panara, SG Piltz, C Brown, W Ma, AW Schreiber, K Koltowska, S Taoudi, PQ Thomas, HS Scott, NL Harvey
    Nature, 2023-01-25;614(7947):343-348.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  22. Dissection of murine collecting lymphatic vessels for imaging, single-cell analysis, and tissue culture of lymphatic muscle cells
    Authors: Guillermo Arroyo-Ataz, Dennis Jones
    STAR Protocols
  23. CCBE1 Is Essential for Epicardial Function during Myocardium Development
    Authors: Fernando Bonet, Sabrina Brito Añez, José Manuel Inácio, Matthias E. Futschik, José Antonio Belo
    International Journal of Molecular Sciences
  24. The cardiopharyngeal mesoderm contributes to lymphatic vessel development in mouse
    Authors: Kazuaki Maruyama, Sachiko Miyagawa-Tomita, Yuka Haneda, Mayuko Kida, Fumio Matsuzaki, Kyoko Imanaka-Yoshida et al.
    eLife
  25. Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARgamma during hyperlipidemia
    Authors: SH Lee, N Kim, M Kim, SH Woo, I Han, J Park, K Kim, KS Park, K Kim, D Shim, SE Park, JY Zhang, DM Go, DY Kim, WK Yoon, SP Lee, J Chung, KW Kim, JH Park, SH Lee, S Lee, SJ Ann, SH Lee, HS Ahn, SC Jeong, TK Kim, GT Oh, WY Park, HO Lee, JH Choi
    Nature Communications, 2022-09-17;13(1):5461.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  26. Imaging Blood Vessels and Lymphatics in Mouse Trachea Wholemounts
    Authors: Peter Baluk, Donald M. McDonald
    Methods in Molecular Biology
  27. SHH and Notch regulate SOX9+ progenitors to govern arcuate POMC neurogenesis
    Authors: E Place, E Manning, DW Kim, A Kinjo, G Nakamura, K Ohyama
    Frontiers in Neuroscience, 2022-08-11;16(0):855288.
    Species: Chicken
    Sample Types: Whole Cells
    Applications: ICC/IF
  28. Conserved meningeal lymphatic drainage circuits in mice and humans
    Authors: Laurent Jacob, Jose de Brito Neto, Stephanie Lenck, Celine Corcy, Farhat Benbelkacem, Luiz Henrique Geraldo et al.
    Journal of Experimental Medicine
  29. Serotonergic regulation of bipolar cell survival in the developing cerebral cortex
    Authors: FK Wong, M Selten, C Rosés-Nove, V Sreenivasa, N Pallas-Baz, E Serafeimid, A Hanusz-God, F Oozeer, R Edwards, O Marín
    Cell Reports, 2022-07-05;40(1):111037.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  30. RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer
    Authors: AE Hall, SÖ Pohl, P Cammareri, S Aitken, NT Younger, M Raponi, CV Billard, AB Carrancio, A Bastem, P Freile, F Haward, IR Adams, JF Caceres, P Preyzner, A von Kriegs, MG Dunlop, FV Din, KB Myant
    Nature Communications, 2022-05-19;13(1):2791.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC, Western Blot
  31. Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities
    Authors: A Choudhury, ST Magill, CD Eaton, BC Prager, WC Chen, MA Cady, K Seo, CG Lucas, TJ Casey-Clyd, HN Vasudevan, SJ Liu, JE Villanueva, TC Lam, JK Pu, LF Li, GK Leung, DL Swaney, MY Zhang, JW Chan, Z Qiu, MV Martin, MS Susko, SE Braunstein, NAO Bush, JD Schulte, N Butowski, PK Sneed, MS Berger, NJ Krogan, A Perry, JJ Phillips, DA Solomon, JF Costello, MW McDermott, JN Rich, DR Raleigh
    Nature Genetics, 2022-05-09;54(5):649-659.
    Species: Human, Xenograft
    Sample Types: Whole Tissue
    Applications: IHC
  32. Dynamic interplay between thalamic activity and Cajal-Retzius cells regulates the wiring of cortical layer 1
    Authors: I Genescu, M Aníbal-Mar, V Kouskoff, N Chenouard, C Mailhes-Ha, H Cartonnet, L Lokmane, FM Rijli, G López-Bend, F Gambino, S Garel
    Cell Reports, 2022-04-12;39(2):110667.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  33. FGFR3 overactivation in the brain is responsible for memory impairments in Crouzon syndrome mouse model
    Authors: Maxence Cornille, Stéphanie Moriceau, Roman H. Khonsari, Yann Heuzé, Léa Loisay, Valérie Boitez et al.
    J Exp Med
  34. Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T�cell de-adhesion and passive transport by flow in inflamed afferent lymphatics
    Authors: MC Friess, I Kritikos, P Schineis, JD Medina-San, AO Gkountidi, A Vallone, EC Sigmund, C Schwitter, M Vranova, C Matti, J Arasa, C Saygili De, E Bovay, ST Proulx, M Tomura, A Rot, DF Legler, TV Petrova, C Halin
    Cell Reports, 2022-02-01;38(5):110334.
    Species: Mouse
    Sample Types: Whole Tissues
    Applications: IHC
  35. Ileitis-associated tertiary lymphoid organs originate at lymphatic valves and obstruct mesenteric lymph flow in response to tumor necrosis factor
    Authors: Rafael S. Czepielewski, Emma C. Erlich, Emily J. Onufer, Shannon Young, Brian T. Saunders, Yong-Hyun Han et al.
    Immunity
  36. Growth factors with valproic acid restore injury-impaired hearing by promoting neuronal regeneration
    Authors: Takahiro Wakizono, Hideyuki Nakashima, Tetsuro Yasui, Teppei Noda, Kei Aoyagi, Kanako Okada et al.
    JCI Insight
  37. Live imaging of neolymphangiogenesis identifies acute antimetastatic roles of dsRNA mimics
    Authors: D Olmeda, D Cerezo-Wal, C Mucientes, TG Calvo, E Cañón, D Alonso-Cur, N Ibarz, J Muñoz, JL Rodriguez-, P Ortiz-Rome, S Ortega, MS Soengas
    Embo Molecular Medicine, 2021-11-11;0(0):e12924.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  38. Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies
    Authors: BR Thomson, P Liu, T Onay, J Du, SW Tompson, S Misener, RR Purohit, TL Young, J Jin, SE Quaggin
    Nature Communications, 2021-10-18;12(1):6072.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  39. Postmitotic Prox1 Expression Controls the Final Specification of Cortical VIP Interneuron Subtypes
    Authors: Tevye Jason Stachniak, Rahel Kastli, Olivia Hanley, Ali Özgür Argunsah, Elianne Grietje Theodora van der Valk, George Kanatouris et al.
    The Journal of Neuroscience
  40. Vegfr3-tdTomato, a reporter mouse for microscopic visualization of lymphatic vessel by multiple modalities
    Authors: E Redder, N Kirschnick, S Bobe, R Hägerling, NR Hansmeier, F Kiefer
    PLoS ONE, 2021-09-20;16(9):e0249256.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  41. Reactive, Adult Neurogenesis From Increased Neural Progenitor Cell Proliferation Following Alcohol Dependence in Female Rats
    Authors: NN Nawarawong, KR Thompson, SP Guerin, C Anasooya S, H Peng, K Nixon
    Frontiers in Neuroscience, 2021-09-14;15(0):689601.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC
  42. Generation of Multipotential NG2 Progenitors From Mouse Embryonic Stem Cell-Derived Neural Stem Cells
    Authors: Masahiro Otsu, Zubair Ahmed, Daniel Fulton
    Frontiers in Cell and Developmental Biology
  43. A neurogenic microenvironment defined by excitatory-inhibitory neuronal circuits in adult dentate gyrus
    Authors: M Uemura, S Blankvoort, SSL Tok, L Yuan, LF Cobar, KK Lit, A Tashiro
    Cell Reports, 2021-07-06;36(1):109324.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  44. Opposing effects of Wnt/ beta -catenin signaling on epithelial and mesenchymal cell fate in the developing cochlea
    Authors: Sara E. Billings, Nina M. Myers, Lee Quiruz, Alan G. Cheng
    Development
  45. Loss of Primary Cilia Protein IFT20 Dysregulates Lymphatic Vessel Patterning in Development and Inflammation
    Authors: Delayna Paulson, Rebecca Harms, Cody Ward, Mackenzie Latterell, Gregory J. Pazour, Darci M. Fink
    Frontiers in Cell and Developmental Biology
  46. Mitochondrial respiration controls the Prox1-Vegfr3 feedback loop during lymphatic endothelial cell fate specification and maintenance
    Authors: Wanshu Ma, Hyea Jin Gil, Xiaolei Liu, Lauren P. Diebold, Marc A. Morgan, Michael J. Oxendine-Burns et al.
    Science Advances
  47. Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma
    Authors: J Schaller, HM Hajjami, S Rusakiewic, K Ioannidou, N Piazzon, A Miles, D Golshayan, O Gaide, D Hohl, DE Speiser, K Schaeuble
    Oncotarget, 2021-03-30;12(7):638-648.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  48. PlexinA4-Semaphorin3A-mediated crosstalk between main cortical interneuron classes is required for superficial interneuron lamination
    Authors: G Limoni, S Murthy, D Jabaudon, A Dayer, M Niquille
    Cell Reports, 2021-01-26;34(4):108644.
    Species: Mouse, Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  49. Blood and lymphatic systems are segregated by the FLCN tumor suppressor
    Authors: I Tai-Nagara, Y Hasumi, D Kusumoto, H Hasumi, K Okabe, T Ando, F Matsuzaki, F Itoh, H Saya, C Liu, W Li, YS Mukouyama, W Marston Li, X Liu, M Hirashima, Y Suzuki, S Funasaki, Y Satou, M Furuya, M Baba, Y Kubota
    Nature Communications, 2020-12-09;11(1):6314.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  50. YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling
    Authors: Boksik Cha, Yen-Chun Ho, Xin Geng, Md. Riaj Mahamud, Lijuan Chen, Yeunhee Kim et al.
    Development
  51. Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus
    Authors: A Rattner, CE Terrillion, C Jou, T Kleven, SF Hu, J Williams, Z Hou, M Aggarwal, S Mori, G Shin, LA Goff, MP Witter, M Pletnikov, AA Fenton, J Nathans
    Elife, 2020-10-21;9(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  52. Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi
    Authors: SP Hong, MJ Yang, H Cho, I Park, H Bae, K Choe, SH Suh, RH Adams, K Alitalo, D Lim, GY Koh
    Nat Commun, 2020-08-14;11(1):4102.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  53. Oncogenic Herpesvirus Engages Endothelial Transcription Factors SOX18 and PROX1 to Increase Viral Genome Copies and Virus Production
    Authors: Silvia Gramolelli, Endrit Elbasani, Krista Tuohinto, Veijo Nurminen, Thomas Günther, Riikka E. Kallinen et al.
    Cancer Research
  54. The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic
    Authors: E Kadosh, I Snir-Alkal, A Venkatacha, S May, A Lasry, E Elyada, A Zinger, M Shaham, G Vaalani, M Mernberger, T Stiewe, E Pikarsky, M Oren, Y Ben-Neriah
    Nature, 2020-07-29;0(0):.
    Species: Mouse, Transgenic Mouse
    Sample Types: Cell Fraction, Cell Lysates, Whole Cells, Whole Tissue
    Applications: IHC, Western Blot
  55. S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling
    Authors: X Geng, K Yanagida, RG Akwii, D Choi, L Chen, Y Ho, B Cha, MR Mahamud, K Berman de, H Ichise, H Chen, J Wythe, CM Mikelis, T Hla, RS Srinivasan
    JCI Insight, 2020-07-23;0(0):.
    Species: Human, Transgenic Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  56. Functional, structural, and molecular identification of lymphatic outflow from subconjunctival blebs
    Authors: Goichi Akiyama, Sindhu Saraswathy, Thania Bogarin, Xiaojing Pan, Ernesto Barron, Tina T. Wong et al.
    Experimental Eye Research
  57. Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation
    Authors: Pieter R Norden, Amélie Sabine, Ying Wang, Cansaran Saygili Demir, Ting Liu, Tatiana V Petrova et al.
    eLife
  58. Atypical cadherin Fat4 orchestrates lymphatic endothelial cell polarity in response to flow
    Authors: KL Betterman, DL Sutton, GA Secker, J Kazenwadel, A Oszmiana, L Lim, N Miura, L Sorokin, BM Hogan, ML Kahn, H McNeill, NL Harvey
    J. Clin. Invest., 2020-06-01;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  59. TGF-beta and TNF-alpha cooperatively induce mesenchymal transition of lymphatic endothelial cells via activation of Activin signals
    Authors: Y Yoshimatsu, S Kimuro, J Pauty, K Takagaki, S Nomiyama, A Inagawa, K Maeda, KA Podyma-Ino, K Kajiya, YT Matsunaga, T Watabe
    PLoS ONE, 2020-05-01;15(5):e0232356.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  60. Functional responses of the hippocampus to hyperexcitability depend on directed, neuron‐specific KCNQ2 K + channel plasticity
    Authors: Chase M. Carver, Shayne D. Hastings, Mileah E. Cook, Mark S. Shapiro
    Hippocampus
  61. A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature
    Authors: Menglan Xiang, Rubén Adrián Grosso, Akira Takeda, Junliang Pan, Tove Bekkhus, Kevin Brulois et al.
    Frontiers in Cardiovascular Medicine
  62. Hippocampal granule cell dispersion: a non-specific finding in pediatric patients with no history of seizures
    Authors: A Roy, KJ Millen, RP Kapur
    Acta Neuropathol Commun, 2020-04-21;8(1):54.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  63. Meningeal lymphatic vessels regulate brain tumor drainage and immunity
    Authors: X Hu, Q Deng, L Ma, Q Li, Y Chen, Y Liao, F Zhou, C Zhang, L Shao, J Feng, T He, W Ning, Y Kong, Y Huo, A He, B Liu, J Zhang, R Adams, Y He, F Tang, X Bian, J Luo
    Cell Res., 2020-02-24;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  64. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta
    Authors: Eric Engelbrecht, Michel V Levesque, Liqun He, Michael Vanlandewijck, Anja Nitzsche, Hira Niazi et al.
    eLife
  65. A Second Heart Field-Derived Vasculogenic Niche Contributes to Cardiac Lymphatics
    Authors: Lioux G, Liu X, Temi�o S et al.
    Developmental Cell
  66. Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease
    Authors: Daniyal J Jafree, Dale Moulding, Maria Kolatsi-Joannou, Nuria Perretta Tejedor, Karen L Price, Natalie J Milmoe et al.
    eLife
  67. Transcription Factor Prospero Homeobox 1 (PROX1) as a Potential Angiogenic Regulator of Follicular Thyroid Cancer Dissemination
    Authors: M Rudzi?ska, M Mikula, KD Arczewska, E Gajda, S Sabali?ska, T St?pie?, J Ostrowski, B Czarnocka
    Int J Mol Sci, 2019-11-10;20(22):.
    Species: Human
    Sample Types: Protein Lysates
    Applications: Western Blot
  68. Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration
    Authors: Dana Gancz, Brian C Raftrey, Gal Perlmoter, Rubén Marín-Juez, Jonathan Semo, Ryota L Matsuoka et al.
    eLife
  69. GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126
    Authors: Md. Riaj Mahamud, Xin Geng, Yen-Chun Ho, Boksik Cha, Yuenhee Kim, Jing Ma et al.
    Development
  70. Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma
    Authors: Benjamin R Thomson, Isabel A Carota, Tomokazu Souma, Saily Soman, Dietmar Vestweber, Susan E Quaggin
    eLife
  71. Embryonic FAP+ lymphoid tissue organizer cells generate the reticular network of adult lymph nodes
    Authors: Alice E. Denton, Edward J. Carr, Lukasz P. Magiera, Andrew J.B. Watts, Douglas T. Fearon
    Journal of Experimental Medicine
  72. High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1
    Authors: A Kasurinen, S Gramolelli, J Hagström, A Laitinen, A Kokkola, Y Miki, K Lehti, M Yashiro, PM Ojala, C Böckelman, C Haglund
    Cancer Med, 2019-09-27;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  73. An important role of cutaneous lymphatic vessels in coordinating and promoting anagen hair follicle growth
    Authors: SY Yoon, LC Dieterich, S Karaman, ST Proulx, SB Bachmann, C Sciaroni, M Detmar
    PLoS ONE, 2019-07-25;14(7):e0220341.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  74. Panicle-Shaped Sympathetic Architecture in the Spleen Parenchyma Modulates Antibacterial Innate Immunity
    Authors: X Ding, H Wang, X Qian, X Han, L Yang, Y Cao, Q Wang, J Yang
    Cell Rep, 2019-06-25;27(13):3799-3807.e3.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  75. Immature excitatory neurons develop during adolescence in the human amygdala
    Authors: SF Sorrells, MF Paredes, D Velmeshev, V Herranz-Pé, K Sandoval, S Mayer, EF Chang, R Insausti, AR Kriegstein, JL Rubenstein, J Manuel Gar, EJ Huang, A Alvarez-Bu
    Nat Commun, 2019-06-21;10(1):2748.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  76. Transcriptional landscape of pulmonary lymphatic endothelial cells during fetal gestation
    Authors: TA Norman, AC Gower, F Chen, A Fine
    PLoS ONE, 2019-05-13;14(5):e0216795.
    Species: Mouse
    Sample Types: fetal lung tissue
    Applications: IHC-P
  77. Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients
    Authors: Maria A.S. Broggi, Lea Maillat, Cristina C. Clement, Natacha Bordry, Patricia Corthésy, Aymeric Auger et al.
    Journal of Experimental Medicine
  78. Molecular Signature of Prospero Homeobox 1 (PROX1) in Follicular Thyroid Carcinoma Cells
    Authors: M Rudzi?ska, M Grzanka, A Stachurska, M Mikula, K Paczkowska, T St?pie?, A Paziewska, J Ostrowski, B Czarnocka
    Int J Mol Sci, 2019-05-05;20(9):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  79. Imaging Lymphatics in Mouse Lungs
    Authors: Peter Baluk, Donald M. McDonald
    Methods in Molecular Biology
  80. Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development
    Authors: RMJ Genga, EM Kernfeld, KM Parsi, TJ Parsons, MJ Ziller, R Maehr
    Cell Rep, 2019-04-16;27(3):708-718.e10.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  81. CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
    Authors: JV Pluvinage, MS Haney, BAH Smith, J Sun, T Iram, L Bonanno, L Li, DP Lee, DW Morgens, AC Yang, SR Shuken, D Gate, M Scott, P Khatri, J Luo, CR Bertozzi, MC Bassik, T Wyss-Coray
    Nature, 2019-04-03;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  82. PDK1 Deficit Impairs the Development of the Dentate Gyrus in Mice
    Authors: M Xu, X Han, R Liu, Y Li, C Qi, Z Yang, C Zhao, J Gao
    Cereb. Cortex, 2019-03-01;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  83. Identification of ILK as a critical regulator of VEGFR 3 signalling and lymphatic vascular growth
    Authors: Sofia Urner, Lara Planas‐Paz, Laura Sophie Hilger, Carina Henning, Anna Branopolski, Molly Kelly‐Goss et al.
    The EMBO Journal
  84. Gq-coupled muscarinic receptor enhancement of KCNQ2/3 channels and activation of TRPC channels in multimodal control of excitability in dentate gyrus granule cells
    Authors: CM Carver, MS Shapiro
    J. Neurosci., 2018-12-28;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  85. Distinct roles of VE ‐cadherin for development and maintenance of specific lymph vessel beds
    Authors: René Hägerling, Esther Hoppe, Cathrin Dierkes, Martin Stehling, Taija Makinen, Stefan Butz et al.
    The EMBO Journal
  86. Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction
    Authors: T Vuorio, E Ylä-Herttu, JP Laakkonen, S Laidinen, T Liimataine, S Ylä-Herttu
    Sci Rep, 2018-11-12;8(1):16709.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  87. Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/?-Catenin Signaling
    Authors: B Cha, X Geng, MR Mahamud, JY Zhang, L Chen, W Kim, EH Jho, Y Kim, D Choi, JB Dixon, H Chen, YK Hong, L Olson, TH Kim, BJ Merrill, MJ Davis, RS Srinivasan
    Cell Rep, 2018-10-16;25(3):571-584.e5.
    Species: Human, Mouse
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC, Western Blot
  88. hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia
    Authors: Duncan I. Mackie, Fuad Al Mutairi, Reema B. Davis, Daniel O. Kechele, Natalie R. Nielsen, Joshua C. Snyder et al.
    Journal of Experimental Medicine
  89. Transcription factor PROX1 suppresses Notch pathway activation via the nucleosome remodeling and deacetylase complex in colorectal cancer stem-like cells
    Authors: J Högström, S Heino, P Kallio, M Lähde, VM Leppänen, D Balboa, Z Wiener, K Alitalo
    Cancer Res., 2018-08-28;0(0):.
    Species: Mouse
    Sample Types: Organoids
    Applications: Flow Cytometry
  90. Reduced expression of PROX1 transitions glioblastoma cells into a mesenchymal gene expression subtype
    Authors: KM Goudarzi, JA Espinoza, M Guo, J Bartek, M Nistér, MS Lindström, D Hägerstran
    Cancer Res., 2018-08-22;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Western Blot
  91. PROX1 is a transcriptional regulator of MMP14
    Authors: S Gramolelli, J Cheng, I Martinez-C, M Vähä-Koske, E Elbasani, E Kaivanto, V Rantanen, K Tuohinto, S Hautaniemi, M Bower, C Haglund, K Alitalo, T Mäkinen, TV Petrova, K Lehti, PM Ojala
    Sci Rep, 2018-06-22;8(1):9531.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: ChIP, Western Blot
  92. Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program
    Authors: M Frye, A Taddei, C Dierkes, I Martinez-C, M Fielden, H Ortsäter, J Kazenwadel, DP Calado, P Ostergaard, M Salminen, L He, NL Harvey, F Kiefer, T Mäkinen
    Nat Commun, 2018-04-17;9(1):1511.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  93. Neurogliaform cortical interneurons derive from cells in the preoptic area
    Authors: M Niquille, G Limoni, F Markopoulo, C Cadilhac, J Prados, A Holtmaat, A Dayer
    Elife, 2018-03-20;7(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  94. Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease
    Authors: S Rhee, JI Chung, DA King, G D'amato, DT Paik, A Duan, A Chang, D Nagelberg, B Sharma, Y Jeong, M Diehn, JC Wu, AJ Morrison, K Red-Horse
    Nat Commun, 2018-01-25;9(1):368.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  95. The role of prospero homeobox 1 (PROX1) expression in follicular thyroid carcinoma cells
    Authors: M Rudzinska, JK Ledwon, D Gawel, J Sikorska, B Czarnocka
    Oncotarget, 2017-12-12;8(69):114136-114155.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  96. Development and plasticity of meningeal lymphatic vessels
    Authors: Salli Antila, Sinem Karaman, Harri Nurmi, Mikko Airavaara, Merja H. Voutilainen, Thomas Mathivet et al.
    Journal of Experimental Medicine
  97. Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling
    Authors: James Hughes, Ruby Dawson, Melinda Tea, Dale McAninch, Sandra Piltz, Dominique Jackson et al.
    Scientific Reports
  98. Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma
    Authors: J Kim, DY Park, H Bae, DY Park, D Kim, CK Lee, S Song, TY Chung, DH Lim, Y Kubota, YK Hong, Y He, HG Augustin, G Oliver, GY Koh
    J. Clin. Invest., 2017-09-18;0(0):.
    Species: Human, Mouse
    Sample Types: Cell Lysates, Whole Cells, Whole Tissue
    Applications: ICC, IHC, Western Blot
  99. Arf6 in lymphatic endothelial cells regulates lymphangiogenesis by controlling directional cell migration
    Authors: YC Lin, N Ohbayashi, T Hongu, N Katagiri, Y Funakoshi, H Lee, Y Kanaho
    Sci Rep, 2017-09-12;7(1):11431.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  100. High PROX1 expression in gastric cancer predicts better survival
    Authors: A Laitinen, C Böckelman, J Hagström, A Kokkola, P Kallio, C Haglund
    PLoS ONE, 2017-08-30;12(8):e0183868.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  101. VIPAR, a quantitative approach to 3D histopathology applied to lymphatic malformations
    Authors: R Hägerling, D Drees, A Scherzinge, C Dierkes, S Martin-Alm, S Butz, K Gordon, M Schäfers, K Hinrichs, P Ostergaard, D Vestweber, T Goerge, S Mansour, X Jiang, PS Mortimer, F Kiefer
    JCI Insight, 2017-08-17;2(16):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  102. Human venous valve disease caused by mutations in FOXC2 and GJC2
    Authors: Oliver Lyons, Prakash Saha, Christopher Seet, Adam Kuchta, Andrew Arnold, Steven Grover et al.
    Journal of Experimental Medicine
  103. Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm's Canal Reporter Rat
    Authors: E Jung, D Gardner, D Choi, E Park, Y Jin Seong, S Yang, J Castorena-, A Louveau, Z Zhou, GK Lee, DP Perrault, S Lee, M Johnson, G Daghlian, M Lee, Y Jin Hong, Y Kato, J Kipnis, MJ Davis, AK Wong, YK Hong
    Sci Rep, 2017-07-17;7(1):5577.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC
  104. Dynamics and function of CXCR4 in formation of the granule cell layer during hippocampal development
    Authors: Y Mimura-Yam, H Shinohara, T Kashiwagi, T Sato, S Shioda, T Seki
    Sci Rep, 2017-07-17;7(1):5647.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  105. Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1
    Authors: SK Jha, K Rauniyar, T Karpanen, VM Leppänen, P Brouillard, M Vikkula, K Alitalo, M Jeltsch
    Sci Rep, 2017-07-07;7(1):4916.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  106. Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity
    Authors: KS Yan, O Gevaert, GXY Zheng, B Anchang, CS Probert, KA Larkin, PS Davies, ZF Cheng, JS Kaddis, A Han, K Roelf, RI Calderon, E Cynn, X Hu, K Mandleywal, J Wilhelmy, SM Grimes, DC Corney, SC Boutet, JM Terry, P Belgrader, SB Ziraldo, TS Mikkelsen, F Wang, RJ von Furste, NR Smith, P Chandrakes, R May, MAS Chrissy, R Jain, CA Cartwright, JC Niland, YK Hong, J Carrington, DT Breault, J Epstein, CW Houchen, JP Lynch, MG Martin, SK Plevritis, C Curtis, HP Ji, L Li, SJ Henning, MH Wong, CJ Kuo
    Cell Stem Cell, 2017-07-06;21(1):78-90.e6.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr, IHC-P
  107. Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4
    Authors: LD Volk-Drape, KL Hall, AC Wilber, S Ran
    PLoS ONE, 2017-06-09;12(6):e0179257.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  108. Fluorescence and Bioluminescence Imaging of Angiogenesis in Flk1-Nano-lantern Transgenic Mice
    Authors: J Matsushita, S Inagaki, T Nishie, T Sakasai, J Tanaka, C Watanabe, KI Mizutani, Y Miwa, K Matsumoto, K Takara, H Naito, H Kidoya, N Takakura, T Nagai, S Takahashi, M Ema
    Sci Rep, 2017-04-20;7(0):46597.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  109. Human umbilical cord plasma proteins revitalize hippocampal function in aged mice
    Authors: JM Castellano, KI Mosher, RJ Abbey, AA McBride, ML James, D Berdnik, JC Shen, B Zou, XS Xie, M Tingle, IV Hinkson, MS Angst, T Wyss-Coray
    Nature, 2017-04-19;544(7651):488-492.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  110. BIG1 is required for the survival of deep layer neurons, neuronal polarity, and the formation of axonal tracts between the thalamus and neocortex in developing brain
    Authors: JJ Teoh, T Iwano, M Kunii, N Atik, E Avriyanti, SI Yoshimura, K Moriwaki, A Harada
    PLoS ONE, 2017-04-17;12(4):e0175888.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  111. Peg3/PW1 is a marker of a subset of vessel associated endothelial progenitors
    Authors: M Malinverno, M Corada, L Ferrarini, L Formicola, G Marazzi, D Sassoon, E Dejana
    Stem Cells, 2017-02-05;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  112. Transcriptomic and anatomic parcellation of 5-HT3AR expressing cortical interneuron subtypes revealed by single-cell RNA sequencing
    Authors: S Frazer, J Prados, M Niquille, C Cadilhac, F Markopoulo, L Gomez, U Tomasello, L Telley, A Holtmaat, D Jabaudon, A Dayer
    Nat Commun, 2017-01-30;8(0):14219.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  113. Dynamic Expression of Sox2, Gata3, and Prox1 during Primary Auditory Neuron Development in the Mammalian Cochlea
    Authors: Koji Nishimura, Teppei Noda, Alain Dabdoub
    PLOS ONE
  114. Vsx1 Transiently Defines an Early Intermediate V2 Interneuron Precursor Compartment in the Mouse Developing Spinal Cord
    Authors: Cédric Francius, María Hidalgo-Figueroa, Stéphanie Debrulle, Barbara Pelosi, Vincent Rucchin, Kara Ronellenfitch et al.
    Frontiers in Molecular Neuroscience
  115. Gene-expression profiling of different arms of lymphatic vasculature identifies candidates for manipulation of cell traffic
    Proc Natl Acad Sci USA, 2016-09-06;113(38):10643-10648.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC
  116. Lymphatic vessels regulate immune microenvironments in human and murine melanoma
    J Clin Invest, 2016-08-15;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  117. Mechanotransduction activates canonical Wnt/?-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves
    Authors: Boksik Cha
    Genes Dev, 2016-06-16;30(12):1454-69.
    Species: Human, Mouse
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC-Fr, Western Blot
  118. Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation
    J Clin Invest, 2016-05-23;0(0):.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: Flow Cytometry, IHC-P
  119. CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity
    J Clin Invest, 2016-05-03;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  120. Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea.
    Authors: Geng R, Noda T, Mulvaney J, Lin V, Edge A, Dabdoub A
    PLoS ONE, 2016-02-09;11(2):e0148339.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC
  121. Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development.
    Authors: Geng X, Cha B, Mahamud M, Lim K, Silasi-Mansat R, Uddin M, Miura N, Xia L, Simon A, Engel J, Chen H, Lupu F, Srinivasan R
    Dev Biol, 2015-11-02;409(1):218-33.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  122. Prox1 Regulates the Subtype-Specific Development of Caudal Ganglionic Eminence-Derived GABAergic Cortical Interneurons
    Authors: Goichi Miyoshi, Allison Young, Timothy Petros, Theofanis Karayannis, Melissa McKenzie Chang, Alfonso Lavado et al.
    The Journal of Neuroscience
  123. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules.
    Authors: Aspelund A, Antila S, Proulx S, Karlsen T, Karaman S, Detmar M, Wiig H, Alitalo K
    J Exp Med, 2015-06-15;212(7):991-9.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  124. Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2
    Authors: Johanna Liebl, Siwei Zhang, Markus Moser, Yan Agalarov, Cansaran Saygili Demir, Bianca Hager et al.
    Nature Communications
  125. A transgenic Prox1-Cre-tdTomato reporter mouse for lymphatic vessel research.
    Authors: Bianchi R, Teijeira A, Proulx S, Christiansen A, Seidel C, Rulicke T, Makinen T, Hagerling R, Halin C, Detmar M
    PLoS ONE, 2015-04-07;10(4):e0122976.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  126. Tie1 is required for lymphatic valve and collecting vessel development
    Authors: Xianghu Qu, Bin Zhou, H. Scott Scott Baldwin
    Developmental Biology
  127. The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis
    Authors: Heidi I. Chen, Bikram Sharma, Brynn N. Akerberg, Harri J. Numi, Riikka Kivelä, Pipsa Saharinen et al.
    Development
  128. VEGF-C and aortic cardiomyocytes guide coronary artery stem development
    Authors: Heidi I. Chen, Aruna Poduri, Harri Numi, Riikka Kivela, Pipsa Saharinen, Andrew S. McKay et al.
    Journal of Clinical Investigation
  129. The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel.
    Authors: Aspelund A, Tammela T, Antila S, Nurmi H, Leppanen V, Zarkada G, Stanczuk L, Francois M, Makinen T, Saharinen P, Immonen I, Alitalo K
    J Clin Invest, 2014-07-25;124(9):3975-86.
    Species: Human, Zebrafish
    Sample Types: Whole Tissue
    Applications: IHC, IHC-P
  130. Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity.
    Authors: Park D, Lee J, Park I, Choi D, Lee S, Song S, Hwang Y, Hong K, Nakaoka Y, Makinen T, Kim P, Alitalo K, Hong Y, Koh G
    J Clin Invest, 2014-07-25;124(9):3960-74.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  131. Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions.
    Authors: Zheng W, Nurmi H, Appak S, Sabine A, Bovay E, Korhonen E, Orsenigo F, Lohela M, D'Amico G, Holopainen T, Leow C, Dejana E, Petrova T, Augustin H, Alitalo K
    Genes Dev, 2014-07-15;28(14):1592-603.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  132. Ectopic hippocampal neurogenesis in adolescent male rats following alcohol dependence
    Authors: Justin A. McClain, Stephanie A. Morris, S. Alexander Marshall, Kimberly Nixon
    Addiction Biology
  133. Bone marrow-derived cells are implicated as a source of lymphatic endothelial progenitors in human breast cancer.
    Authors: Van't Hull E, Bron S, Henry L, Ifticene-Treboux A, Turrini R, Coukos G, Delaloye J, Doucey M
    Oncoimmunology, 2014-06-25;3(0):e29080.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  134. Murine Notch1 is required for lymphatic vascular morphogenesis during development.
    Authors: Fatima A, Culver A, Culver F, Liu T, Dietz W, Thomson B, Hadjantonakis A, Quaggin S, Kume T
    Dev Dyn, 2014-04-17;243(7):957-64.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  135. Blimp1 (Prdm1) prevents re-specification of photoreceptors into retinal bipolar cells by restricting competence.
    Authors: Brzezinski J, Uoon Park K, Reh T
    Dev Biol, 2013-10-12;384(2):194-204.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  136. The germinal matrices in the developing dentate gyrus are composed of neuronal progenitors at distinct differentiation stages.
    Authors: Sugiyama T, Osumi N, Katsuyama Y
    Dev Dyn, 2013-10-07;242(12):1442-53.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  137. Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation
    Authors: Sandrine Levet, Delphine Ciais, Galina Merdzhanova, Christine Mallet, Teresa A. Zimmers, Se-Jin Lee et al.
    Blood
  138. A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy.
    Authors: Hagerling R, Pollmann C, Andreas M, Schmidt C, Nurmi H, Adams R, Alitalo K, Andresen V, Schulte-Merker S, Kiefer F
    EMBO J, 2013-01-08;32(5):629-44.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  139. Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis.
    Blood, 2012-04-30;119(24):5931-42.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC-P
  140. Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival.
    Blood, 2012-02-28;119(24):5850-8.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  141. Mechanoinduction of lymph vessel expansion
    Authors: Lara Planas-Paz, Boris Strilić, Axel Goedecke, Georg Breier, Reinhard Fässler, Eckhard Lammert
    The EMBO Journal
  142. Expression and prognostic value of transcription factor PROX1 in colorectal cancer.
    Authors: Skog M, Bono P, Lundin M, Lundin J, Louhimo J, Linder N, Petrova TV, Andersson LC, Joensuu H, Alitalo K, Haglund CH
    Br. J. Cancer, 2011-10-04;105(9):1346-51.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  143. CKIalpha ablation highlights a critical role for p53 in invasiveness control.
    Authors: Elyada E, Pribluda A, Goldstein RE, Morgenstern Y, Brachya G, Cojocaru G, Snir-Alkalay I, Burstain I, Haffner-Krausz R, Jung S, Wiener Z, Alitalo K, Oren M, Pikarsky E, Ben-Neriah Y
    Nature, 2011-02-17;470(7334):409-13.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC-P, Western Blot
  144. PCNA interacts with Prox1 and represses its transcriptional activity
    Authors: Xiaoren Chen, Tapan P. Patel, Vladimir I. Simirskii, Melinda K. Duncan
    Mol Vis
  145. Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase.
    Authors: Philipp M, Fralish GB, Meloni AR, Chen W, MacInnes AW, Barak LS, Caron MG
    Mol. Biol. Cell, 2008-09-24;19(12):5478-89.
    Species: Zebrafish
    Sample Types: Whole Tissue
    Applications: IHC
  146. The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis.
    Authors: Heckman CA, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Yla-Herttuala S, Wedge SR, Jurgensmeier JM, Alitalo K
    Cancer Res., 2008-06-15;68(12):4754-62.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  147. Molecular Anatomy of the Developing Human Retina.
    Authors: Hoshino A, Ratnapriya R, Brooks MJ et al.
    Dev. Cell
  148. 1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development
    Authors: Wang T, Wang Z, de Fabritus L Et al.
    Developmental cell

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Human Prox1 Antibody
By Anonymous on 07/25/2023
Application: IHC Sample Tested: Lymph node tissue Species: Human

IHC-P: pH 9 antigen retrieval, primary Ab x50 30min, HRP-polymer detection system + DAB

Immunohistochemistry Human Prox1 Antibody AF2727
Human Prox1 Antibody
By Anonymous on 08/10/2017
Application: Immunocytochemistry/Immunofluorescence Sample Tested: Embryonic kidney Species: Mouse
Immunocytochemistry/Immunofluorescence Human Prox1 Antibody AF2727