Mouse ALK-1 Antibody Summary
Asp23-Pro119
Accession # Q61288
Applications
Mouse ALK-1 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: ALK-1
Transforming growth Factor beta (TGF-beta ) superfamily ligands exert their biological activities via binding to heteromeric receptor complexes of two types (I and II) of serine/threonine kinases. Type II receptors are constitutively active kinases that phosphorylate type I receptors upon ligand binding. In turn, activated type I kinases phosphorylate downstream signaling molecules including the various smads. Transmembrane proteoglycans, including the type III receptor (betaglycan) and endoglin, can bind and present some of the TGF-beta superfamily ligands to type I and II receptor complexes and enhance their cellular responses. Seven type I receptors (also termed activin receptor-like kinase (ALK)) and five type II receptors have been isolated from mammals. ALK-2, -3, -4, -5, and -6 are also known as Activin R1A, BMPR-1A, Activin R1B, TGF-beta R1, and BMPR-1B, respectively, reflecting their ligand preferences. Evidence suggests that TGF-beta 1, TGF-beta 3 and an unknown ligand present in serum can activate chimeric ALK-1. ALK-1 shares with other type I receptors a cysteine-rich domain with conserved cysteine spacing in the extracellular region, and a glycine-and serine-rich domain (the GS domain) preceding the kinase domain. ALK-1 is expressed highly in endothelial cells and other highly vascularized tissues. The expression patterns of ALK-1 parallels that of endoglin. Mutations in ALK-1 as well as in endoglin are associated with hereditary hemorrhagic telangiectasia (HHT), suggesting a critical role for ALK-1 in the control of blood vessel development or repair. Human and mouse ALK-1 share approximately 71% amino acid sequence identity in their extracellular regions.
- ten Dijke, P. et al. (1993) Oncogene 8:2879.
- ten Dijke, P. et al. (1994) Science 264:101.
- Lux, A. et al. (1999) J. Biol. Chem. 274:9984.
Product Datasheets
Citations for Mouse ALK-1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
10
Citations: Showing 1 - 10
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SnoN facilitates ALK1–Smad1/5 signaling during embryonic angiogenesis
Authors: Qingwei Zhu, Yong Hwan Kim, Douglas Wang, S. Paul Oh, Kunxin Luo
Journal of Cell Biology
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BMP9 (Bone Morphogenetic Protein-9)/Alk1 (Activin-Like Kinase Receptor Type I) Signaling Prevents Hyperglycemia-Induced Vascular Permeability
Authors: Naoufal Akla, Claire Viallard, Natalija Popovic, Cindy Lora Gil, Przemyslaw Sapieha, Bruno Larrivée
Arteriosclerosis, Thrombosis, and Vascular Biology
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ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway
Authors: Bruno Larrivée, Claudia Prahst, Emma Gordon, Raquel del Toro, Thomas Mathivet, Antonio Duarte et al.
Developmental Cell
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Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models
Authors: M Morita, A Yoneda, N Tokunoh, T Masaki, K Shirakura, M Kinoshita, R Hashimoto, N Shigesada, J Takahashi, M Tachibana, S Tanaka, M Obana, N Hino, M Ikawa, K Tsujikawa, C Ono, Y Matsuura, H Kidoya, N Takakura, Y Kubota, T Doi, K Takayama, Y Yoshioka, Y Fujio, Y Okada
Proceedings of the National Academy of Sciences of the United States of America, 2023-01-12;120(3):e2213317120.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
BMP9 signaling promotes the normalization of tumor blood vessels
Authors: C Viallard, C Audiger, N Popovic, N Akla, K Lanthier, I Legault-Na, H Melichar, S Costantino, S Lesage, B Larrivée
Oncogene, 2020-02-10;0(0):.
Species: Mouse, Transgenic Mouse
Sample Types: Whole Tissue
Applications: IHC -
PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia
Nat Commun, 2016-11-29;7(0):13650.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
BMP9/ALK1 inhibits neovascularization in mouse models of age-related macular degeneration
Authors: K Ntumba, N Akla, SP Oh, A Eichmann, B Larrivée
Oncotarget, 2016-08-30;7(35):55957-55969.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Endothelial beta4 integrin is predominantly expressed in arterioles, where it promotes vascular remodeling in the hypoxic brain.
Authors: Welser-Alves J, Boroujerdi A, Tigges U, Wrabetz L, Feltri M, Milner R
Arterioscler Thromb Vasc Biol, 2013-03-07;33(5):943-53.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth.
Authors: Mitchell D, Pobre EG, Mulivor AW, Grinberg AV, Castonguay R, Monnell TE, Solban N, Ucran JA, Pearsall RS, Underwood KW, Seehra J, Kumar R
Mol. Cancer Ther., 2010-02-02;9(2):379-88.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Induction of Brain Arteriovenous Malformation Through CRISPR/Cas9-Mediated Somatic Alk1 Gene Mutations in Adult Mice
Authors: Wan Zhu, Daniel Saw, Miriam Weiss, Zhengda Sun, Meng Wei, Sonali Shaligram et al.
Translational Stroke Research
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