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Mouse IFN-beta Antibody

Catalog #: 22400-1
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
22400-1
Product Details
Citations (4)
FAQs
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse IFN-beta Antibody Summary

Species Reactivity
Mouse
Specificity
Weakly neutralizes mouse interferon beta, but not recommended for neutralization assays; binds to mouse interferon beta
Source
Monoclonal Rat IgG2A Clone # RMMB-1
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Human interferon beta
Formulation
Phosphate buffered saline (PBS) containing 0.1% bovine serum albumin (BSA)
Label
Unconjugated

Applications

Recommended Concentration
Sample
Direct ELISA
Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
After receipt, the product may be stored at -20°C for short-term use (≤ 6 months). For
long-term storage, we recommend storing the product at -70°C or below for retention of full activity. When thawing, the
contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum.
Refreezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers
containing protein such as 0.1% bovine serum albumin (BSA).

Background: IFN-beta

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

Long Name
Interferon beta
Entrez Gene IDs
3456 (Human); 15977 (Mouse); 24481 (Rat)
Alternate Names
Fibroblast interferon; IFB; IFBIFNB; IFF; IFNB; IFNB1; IFNbeta; IFN-beta; interferon beta; interferon, beta 1, fibroblast; MGC96956

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Citations for Mouse IFN-beta Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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  1. Identification of Toll-like receptor 9 as parapoxvirus ovis-sensing receptor in plasmacytoid dendritic cells.
    Authors: von Buttlar H, Siegemund S, Buttner M, Alber G
    PLoS ONE, 2014-08-29;9(8):e106188.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  2. Microarray analyses demonstrate the involvement of type I interferons in psoriasiform pathology development in D6-deficient mice.
    Authors: Baldwin H, Pallas K, King V, Jamieson T, McKimmie C, Nibbs R, Carballido J, Jaritz M, Rot A, Graham G
    J Biol Chem, 2013-11-05;288(51):36473-83.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  3. Evaluating vaccinia virus cytokine co-expression in TLR GKO mice.
    Authors: Sutherland DB, Ranasinghe C, Regner M, Phipps S, Matthaei KI, Day SL, Ramshaw IA
    Immunol. Cell Biol., 2010-12-21;89(0):706-15.
    Species: Mouse
    Sample Types: Serum
    Applications: ELISA Development
  4. Effects of type I interferons on the adjuvant properties of plasmid granulocyte-macrophage colony-stimulating factor in vivo.
    Authors: Qin L, Greenland JR, Moriya C
    J. Virol., 2007-07-25;81(19):10606-13.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization

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