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Mouse BOC Antibody

Catalog #: AF2385
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
AF2385
AF2385-SP
Product Details
Citations (5)
FAQs
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse BOC Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse BOC in direct ELISAs and Western blots. In Western blots, approximately 25% cross‑reactivity with recombinant human BOC is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse BOC
Asp26-Lys508 (Gln ins) Val509-Asp846
Accession # AAH78631
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Mouse BOC
Immunohistochemistry
5-15 µg/mL
Immersion fixed frozen sections of mouse embryo (E13.5-15.5)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: BOC

BOC and CDO (cell adhesion molecule-related/down-regulated by oncogenes) are cell surface receptors belonging to the Ig/fibronectin type III (FNIII) repeat family. Both proteins have five Ig repeats and three FNIII repeats in their extracellular domains, an arrangement shared by Robo proteins. BOC and CDO are co-expressed in muscle precursor cells during development. BOC associates with CDO in cis and forms complexes with cadherins to regulate myogenic differentiation.

Long Name
Brother of CDO
Entrez Gene IDs
91653 (Human); 117606 (Mouse)
Alternate Names
Boc homolog (mouse); BOC; brother of CDO; Protein BOC

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Citations for Mouse BOC Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. Coordination of canonical and noncanonical Hedgehog signalling pathways mediated by WDR11 during primordial germ cell development
    Authors: Lee, J;Kim, Y;Ataliotis, P;Kim, HG;Kim, DW;Bennett, DC;Brown, NA;Layman, LC;Kim, SH;
    Scientific reports
    Species: Mouse
    Sample Types: Cell Lysate
    Applications: Western Blot
  2. Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration
    Authors: Y Kim, J Lee, M Seppala, MT Cobourne, SH Kim
    Nat Commun, 2020-04-24;11(1):1994.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  3. SGTb regulates a surface localization of a guidance receptor BOC to promote neurite outgrowth
    Authors: TA Vuong, SJ Lee, YE Leem, JR Lee, GU Bae, JS Kang
    Cell. Signal., 2019-01-09;55(0):100-108.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  4. Distinct structural requirements for CDON and BOC in the promotion of Hedgehog signaling
    Authors: Jane Y. Song, Alexander M. Holtz, Justine M. Pinskey, Benjamin L. Allen
    Developmental Biology
  5. Segregation of ipsilateral retinal ganglion cell axons at the optic chiasm requires the Shh receptor Boc.
    Authors: Fabre PJ, Shimogori T, Charron F
    J. Neurosci., 2010-01-06;30(0):266.
    Species: Mouse, Rat
    Sample Types: Whole Tissue
    Applications: IHC-P

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